Results 81 to 90 of about 3,186,450 (234)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves

International Journal of Veterinary Science and Medicine, 2016
Babesia is one of the main causes of anemia in cattle, a lot of elucidations have been suggested to explain its pathogenesis. This study was designed to investigate clinical, hemato-biochemical and oxidant/antioxidant status and its relation with the ...
Noha Y. Salem, Shimaa G. Yehia, Heba S. Farag, Mohammed Awny Elkhiat   +3 more
doaj   +1 more source

Antibiotic Stewardship Implementation and Antibiotic Use at Hospitals With and Without On-site Infectious Disease Specialists. [PDF]

, 2020
BackgroundMany US hospitals lack infectious disease (ID) specialists, which may hinder antibiotic stewardship efforts. We sought to compare patient-level antibiotic exposure at Veterans Health Administration (VHA) hospitals with and without an on-site ID
Alexander, Bruce, Beck, Brice F, Goetz, Matthew B, Goto, Michihiko, Livorsi, Daniel J, Lund, Brian C, Nair, Rajeshwari, Ohl, Michael, Perencevich, Eli N, Vaughan-Sarrazin, Mary S   +9 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Clinical manifestations in trisomy 9 mosaicism

The Turkish Journal of Pediatrics, 2018
Trisomy 9 is a rare chromosome abnormality which can occur in a mosaic or nonmosaic state with similar clinical features. The authors present a male with mosaic trisomy 9 from birth to 6 months of life.
Ljiljana Pejcic, Tatijana Stankovic, Marija Ratkovic-Jankovic, Karin Vasic, Ivana Nikolic   +4 more
doaj   +1 more source

Understanding Learned Models by Identifying Important Features at the Right Resolution

, 2018
In many application domains, it is important to characterize how complex learned models make their decisions across the distribution of instances. One way to do this is to identify the features and interactions among them that contribute to a model's ...
Craven, Mark, Lee, Kyubin, Sood, Akshay
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Asthma in Individuals Over 60 Years: A Comparative Analysis Across Age Subgroups

Journal of Asthma and Allergy
Martyna Miodońska,1 Andrzej Bożek,1 Ewa Urbaniec,2 Dominika Sadowska,1 Aleksandra Mitka,1 Aleksandra Foks-Ciekalska,1 Szymon Mućka,1 Anna Kwaśniak,1 Jolanta Zalejska-Fiolka,3 Marita Nittner-Marszalska4 1Clinical ...
Miodońska M, Bożek A, Urbaniec E, Sadowska D, Mitka A, Foks-Ciekalska A, Mućka S, Kwaśniak A, Zalejska-Fiolka J, Nittner-Marszalska M   +9 more
doaj  

Factors influencing mortality in prevalent hemodialysis patients with different types of heart failure: Single-center experience [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective. This retrospective longitudinal study aimed to analyze survival factors in prevalent hemodialysis (HD) patients with different heart failure (HF) phenotypes. Methods.
Dobričić Marija, Pakić Vesna, Pejović Vesna, Kuzmanović Aleksandra, Milić Miodrag, Marinković Jelena, Ležaić Višnja   +6 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source