Results 161 to 170 of about 115,028,515 (254)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Additional sectioning and AI-assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from BRCA1/2 carriers. [PDF]

Histopathology
Bouwmeester AB, Gootzen TA, Nobbenhuis M, Rudaitis V, van den Berg CB, van Beekhuizen HJ, Alcalá LS, Smedts DP, Visser NC, Verhoef V, Jonges TG, Zweemer RP, Leon-Catillo A, Lems C, de Hullu JA, van der Laak JA, Steenbeek MP, Simons M.   +17 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Simulation-guided outlet valve repair: early integration of computationally-derived principles of free-edge length in bicuspidization repair. [PDF]

Front Cardiovasc Med
Choi PS, Kaiser AD, Nilkant R, Sharir A, Siddiqi U, McMullen HL, Marsden AL, Ma MR.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Impact of molecular profiling in patients with endometrial cancer: real world experience from India. [PDF]

Front Oncol
Kaushik R, Chakraborti B, Ghosh A, Chakraborty S, Bhattacharyya T, Mishra J, Rout S, Midha D, Mishra D, Vinarkar S, Roy S, Chowdhury OR, Bhaumik J.   +12 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From Documents to Digital: Co-Designing Nutrition Information Videos With Consumers and Dietitians. [PDF]

Health Expect
Olufson H, Do H, Noble B, Power G, Moore J, Ong R, Harding S, Robertson S, Gunawardena T, Ellick J, Young A.   +10 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Genetic Diversity of Clade 2.3.4.4b H5Nx high pathogenicity Avian Influenza Viruses detected in Korea during the 2025-2026 winter season and pathogenicity of H5N1 and H5N9 viruses. [PDF]

Virus Res
Jang Y, Cha RM, Park MJ, Kim JM, Lim EH, Heo GB, An SH, Lee B, Seo HJ, Lee KN, Lee YJ, Lee EK.   +11 more
europepmc   +1 more source