Results 211 to 220 of about 115,028,515 (254)

Has the required heparin dose increased in PCI? A single-centre experience. [PDF]

Br J Cardiol
Kira M, Abouelasaad M, Elshafey A, Darwish M, Patil RJ, Zubair Z, Calver A, Corbett S, Jabbour R, Mahmoudi M, Rawlins J, Sirohi R, Wilkinson J, Hinton J, Curzen N.   +14 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Mixture Effects Investigation of a Thyroid Hormone System-Specific Interaction with Azole Fungicides. [PDF]

Toxics
Kadic A, Reetz AE, Fischer BC, Sylla BS, Feiertag K, Ritz V, Heise T, Marx-Stoelting P, Tralau T, Solano MLM.   +9 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Health System Capacity to Deliver Routine Childhood Immunisations: An Assessment of Health Facilities in Gazelle and Kokopo Districts, East New Britain. [PDF]

Vaccines (Basel)
Dalton M, Vaccher S, Morgan C, Sanderson B, Melepia P, James HA, Duwaba L, Paivu B, Kiromat P, Stanley E, Waramin E, Laman M, Homer CSE, Scoullar MJL, Robinson LJ, Danchin M, Pomat W.   +16 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Molecular and serological characterization of SARS-CoV-2 strains associated with viral encephalitis in Senegal during the COVID-19 pandemic. [PDF]

New Microbes New Infect
Top FK, Kahwagi J, Diagne R, Seye AO, Faye R, Diagne MM, Ndiaye B, Fall G, Sall AA, Faye O, Dia N, Vigan-Womas I, Faye M, Heraud JM.   +13 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Comparative effects of combined omeprazole and dose-escalated striatin therapy versus monotherapy on VEGF, ITF, gastric ulcer area, epithelial thickness, and inflammatory response in rats with aspirin-induced gastric injury. [PDF]

Front Pharmacol
Purnomo HD, Hendrianingtyas M, Rachman R, Roosana SN, Indiarso D, Hutami HT, Permatadewi CO, Istiadi H, Pralampita PW, Dharminto, Tjandrawinata RR.   +10 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source