Results 61 to 70 of about 115,028,515 (254)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Summary report no. 5, February 1948 [PDF]

, 2009
Includes: foreword, Project Whirlwind, the Whirlwind computers, and reports; Whirlwind I layout and construction; project staff and new staff members; visitors; visits; time schedules; the effects on computing speed of access time, pulse repetition ...
Project Whirlwind Research Staff
core  

Prediction of extreme floods of the Feilaixia reservoir in the Beijiang River basin under climate change

Shui kexue jinzhan, 2015
In this paper,the downscaling results of the multi-model dataset from the Coupled Model Intercomparison Project Phase 5(CMIP5) were coupled with the Variable Infiltration Capacity(VIC) model to predict future floods of the Feilaixia reservoir in the ...
HUANG Guoru, WU Chuanhao, LIU Zhiyu, CHEN Zhijing, HU Jianwei, YIN Zhijie   +5 more
doaj   +1 more source

Teaching Innovation in Volunteer Sprits for a Social Development Course for Developing Working Essential Skills towards EEC of Burapha University Students [PDF]

Journal of Humanities and Social Sciences Mahasarakham University, 2021
The purposes of this study were to create teaching innovation in Volunteer Sprits for Social Development Course for Developing Working Essential Skills towards EEC area of Burapha University Students and to develop the integration in teaching progress on
Phattharmanat Sritrakul
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Global Rankings of Universities as a New Phenomenon in Russian Higher Education

Социологическая наука и социальная практика, 2014
The article describes a project that was launched in 2013 that stated that by 2012, at least 5 Russian universities must be included in the following top world university ratings: the Times Higher Education World University Rankings (THE), QS World ...
Alexander L. Arefiev
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

REGROUP project

, 2023
The Horizon Europe project REGROUP provides the EU with actionable advice on how to rebuild post-pandemic governance and public policies in an effective and democratic way.
REGROUP project
core   +1 more source