Results 91 to 100 of about 2,069,563 (248)
Thoughts of G. Mazzini in “The Circle of Reading” by L.N. Tolstoy
Язык и текстThanks to the earliest Russian translations of Giuseppe Mazzini’s major work, I doveri dell’uomo (The Duties of Man), L.N. Tolstoy became acquainted with the ideas of one of the leading figures of the Italian Risorgimento for whom ...
A. Cavazza
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Reading Circle List for 2014 [PDF]
, 2014 Reading Circle is a monthly event organised by the Faculty of Social Sciences. The objective is to inculcate the spirit of inquiry and intellectual discussion based on the readings of key texts in social sciences.
Sharifah S., Wan Ahmad
core
Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy. [PDF]
Ann Clin Transl NeurolABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Saravanan A +7 more
europepmc +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Lightweight Meter Pointer Recognition Method Based on Improved YOLOv5
SensorsIn substation lightning rod meter reading data taking, the classical object detection model is not suitable for deployment in substation monitoring hardware devices due to its large size, large number of parameters, and slow detection speed, while is ...
Chi Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Built HeritageNo. 1262 Yan'an West Road and No. 60 Panyu Road in Shanghai were previously part of Columbia Circle, which began construction in 1924, and the base of the Shanghai Institute of Biological Products (SIBP) from 1951 to 2014.
Jiao Wu +5 more
doaj +1 more source