Results 121 to 130 of about 891,700 (258)
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Detecting Cognitive Load during Working Memory Tasks utilizing a Digitizer Tablet [PDF]
, 2017 The purpose of this line of research is to determine whether the ‘Digitizer’ is a reliable and valid way to measure cognitive load during dual working memory-drawing tasks.
Srivastava, Pradyumn, Ward, Cassandra K
core +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
"Exercícios de raciocínio" em três linguagens: ensino de física nas séries iniciais
Ensaio Pesquisa em Educação em Ciências, 2002 In order to study the fitness of child's tales as a Physic Teaching instrument, we elaborated a science learning activity to second grade students of an elementary public school in São Paulo city.
Maria da Conceição Barbosa Lima +1 more
doaj
Built HeritageNo. 1262 Yan'an West Road and No. 60 Panyu Road in Shanghai were previously part of Columbia Circle, which began construction in 1924, and the base of the Shanghai Institute of Biological Products (SIBP) from 1951 to 2014.
Jiao Wu +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
, 2003 The purpose of this activity is to determine the amount of moisture input to the local environment by measuring rain and snowfall and to measure the pH of precipitation.
The GLOBE Program, UCAR (University Corporation for Atmospheric Research)
core
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source