Results 71 to 80 of about 4,407 (150)
Curcumin alleviates myocardial inflammatory responses by inhibiting Wnt5a/β-Catennin pathway after coronary microembolization in rats [PDF]
Objective To explore the potential mechanisms of curcumin on myocardial inflammatory responses following coronary microembolization (CME) in rats. Methods Thirty-two SD rats were randomly divided into a sham group, a CME group (model group), a CME ...
LI Lang +4 more
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低强度聚焦超声触发PLGA阿霉素在细胞内空化增加乳腺癌细胞死亡 [PDF]
, 2021 目的探讨低强度聚焦超声能否触发聚乳酸-羟基乙酸共聚物（PLGA）包裹阿霉素在细胞内的空化作用以增加4T1肿瘤细胞的死亡。方法采用双乳化溶剂蒸发法制备了负载阿霉素的聚乳酸-羟基乙酸共聚物（PLGA）纳米气泡。设立细胞内释药组，细胞外释药组，传统给药组，单独超声组和对照组。用流式细胞仪检测各组细胞的死亡情况，用细胞活力检测试剂盒（CCK8）检测各组的细胞增殖，细胞划痕检测各组的侵袭情况。结果超声组细胞核的红色荧光平均强度高于对照组，差异具有统计学意义（t=16.627，P<0.001）；聚乳酸 ...
严飞, 李绍林, 罗琼, 黄盘辉
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Zhongguo shiyan zhenduanxue, 2019 乳腺淋巴瘤可分为原发性乳腺淋巴瘤和继发性乳腺淋巴瘤,乳腺原发淋巴瘤以非霍奇金淋巴瘤为主[1-3]。同时,乳腺原发淋巴瘤通常是以偶然发现乳腺结节或伴有同侧腋窝淋巴结肿大为首发症状,与乳腺癌的临床表现无明显差异,因此容易误诊或漏诊[4]。本研究通过分析22例乳腺原发淋巴瘤病例的病理类型、临床表现及辅助检查 ...
鲁鹤臻 +6 more
doaj
Research Progress on Bioactivity and Mechanism of Tea Polyphenols [PDF]
Tea polyphenols are a class of polyphenolic mixtures with phenolic hydroxyl structure in tea plants, which are the main functional component of tea, and the content is relatively high in green tea. Tea polyphenol bioactivity research gains popularity, in
Hongyan YI +7 more
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The research on construction of the spontaneous prostate tumor and breast cancer model of Ptenfl/fl;Trp53fl/fl;Pbsn-iCre+ transgenic mouse [PDF]
Background and purpose: Prostate cancer and breast cancer are highly prevalent malignant tumors, and there occurrence and development are related to the tumor suppressor genes phosphatase and tensin homolog deleted on chremosome ten (Pten) and the ...
WU Jiachen, HE Lina, TANG Xinru, TANG Shuang
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Zhongguo shiyan zhenduanxue, 2005 目的 研究乳腺癌P5 3、CA15 3表达与肿瘤分化、浸润转移的关系及其临床意义。方法 分别应用免疫组化法（IHC）及血清放射免疫分析法（IRMA） ,检测P5 3、CA15 3在6 3例乳腺癌及2 5例乳腺良性病变中的表达情况。结果 在6 3例乳腺癌中P5 3和CA15 3阳性率分别为33 3%和4 9 .2 % ,CA15 3血清含量为38. 3±2. 9 3U/ml,均明显高于良性对照组（P
黄玉钿 +4 more
doaj
The expression of PKCs in malignant tumor and the effects of Amoitone A against gastric cancer cells [PDF]
, 2008 肿瘤是一种基因疾病，其发生机理及抗肿瘤药物的研发是当前生命科学研究的热点。本文应用现代生物学技术，观察乳腺癌、胃癌组织中PKCs表达及与肿瘤分化程度的相关性，研究PKCαsiRNA和阿霉酮A在体内外对胃癌细胞BGC-823的作用，对探索肿瘤发生、发展的分子机理和开发抗肿瘤药物及新技术具有重要的学术意义和潜在的应用价值。 首先，研究了蛋白激酶C(ProteinKinaseC，PKC)和乳腺癌分化及转移的相关性。通过免疫组织化学方法检测48例乳腺癌病人手术标本PKC同功酶蛋白表达 ...
张鸣青
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Zhongguo shiyan zhenduanxue, 2006 目的探讨sFas的产生机制及其作为乳腺癌早期诊断标志物的可行性。方法采用ELISA方法对sFas在不同乳腺疾病和正常乳腺组织中以及在不同病理类型乳腺癌中的浓度水平进行比较分析;采用ELISA方法和流式细胞技术对乳腺癌中血清sFas的浓度水平与Fas的表达和临床各病理学参数之间的关系进行比较分析。结果乳腺癌sFas浓度水平明显高于乳腺良性疾病及正常对照组,乳腺不典型增生中sFas水平又明显高于乳腺腺瘤及正常对照组,结果具有显著性差异;在不同病理类型乳腺癌中sFas水平无显著性差异 ...
陈云波, 王心明, 姜瑛, 徐立
doaj
The Role of SRC-3 in Hepatocyte Proliferation and Xenobiotic Metabolism in the Liver [PDF]
, 2009 类固醇激素受体辅激活子（steroidreceptorcoactivator，SRC）作为一类转录协同因子，能够与多种转录因子相互作用并增强其转录活性。SRC-3是SRC家族（SRC-1/NCoA1、SRC-2/GRIP/TIF2、SRC-3/AIB1/ACTR/pCTP/RAC3/TRAM-1）的一员。SRC-3基因敲除会导致小鼠发育延迟、雌鼠乳腺泡萎缩，并导致对雌激素和孕酮的部分耐受性。SRC-3在肿瘤细胞发生发展的过程中也起到了重要的作用，其既有癌基因的作用，又有肿瘤抑制因子的功效 ...
王小亮
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Visualization Analysis of Research Hotspots of Breast Cancer Microenvironment Based on CiteSpace and VOSviewer [PDF]
ObjectiveTo explore the status of knowledge graph-based research into breast cancer microenvironment and to predict future research hotspots. MethodsThe literature related to breast cancer microenvironment in recent 20 years was retrieved from CNKI and ...
Liyuan FANG +7 more
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