The preparation and biological activity research of Gypenoside of Gynostemma pentaphyllum and its metaboliezd product by microorganic transformation [PDF]
, 2012 绞股蓝[Gynostemmapentaphyllum(Thunb)Makino]为葫芦科多年生落叶草质宿根藤本植物，是目前已知的除五加科植物人参属以外，唯一含有人参皂苷类成分的植物。大量研究表明，绞股蓝皂苷在抗氧化、抗炎、抗癌、改善免疫力等方面都表现出较高活性，因此绞股蓝一直都是研究开发中备受关注的药用植物。 本论文是从绞股蓝中提取绞股蓝总皂苷，通过微生物转化，切除绞股蓝皂苷侧链的糖苷，从而获得经过微生物代谢后的次级绞股蓝皂苷。并比较研究转化前后绞股蓝总皂苷的生物学效应。主要研究内容及结果如下 ...
秦江
core
Effects of White Quinoa Polysaccharide on Regulation of Glucolipid Metabolism in Type 2 Diabetic Mice [PDF]
To investigate the hypoglycemic and lipid-lowering effects of white quinoa polysaccharide (WQP) in type 2 diabetic model mice, the mice were divided into model group, polysaccharide group (800 mg/kg) and normal control group.
Changyuan WANG +3 more
core +1 more source
人参皂苷Rb1对糖氧剥夺所致SH-SY5Y细胞凋亡的影响及机制研究
Zhongguo shiyan zhenduanxue, 2016 目的为了探讨人参皂甙Rb1（GRb1）对糖氧剥夺（OGD）所致SH-SY5Y细胞损伤的保护作用及GRb1的保护作用机制。方法采用体外培养SH-SY5Y细胞,应用MTT法、TUNEL染色、流式细胞仪、Western Blotting等方法检测GRb1对糖氧剥夺所致SH-SY5Y细胞凋亡的抑制作用。结果 GRb1预处理能增强OGD损伤细胞的生存能力,抑制OGD诱导的SH-SY5Y细胞凋亡。进一步研究显示GRb1能抑制由OGD线粒体膜电位的降低和线粒体内细胞色素C（cyct C）的释放 ...
高丽 +4 more
doaj
谷氨酸受体拮抗剂可通过调节脑源性神经营养因子水平改善强迫症模型小鼠的刻板行为 [PDF]
目的在RU24969强迫症（OCD）小鼠模型中探究NMDA受体拮抗剂氟乙基美金刚（FENM）能否改善强迫样行为及探索其潜在机制。方法将32只小鼠随机分成Saline组（n=8），RU24969组（n=8），RU+FENM组（n=8），FENM组（n=8），根据不同组别分别给予FENM或等量生理盐水进行预处理，30 min后再予RU24969或等量生理盐水进行造模。造模后1 h进行行为学测试，测试结束后取血清检测脑源性神经营养因子（BDNF）的水平。于尾静脉注射伊文思蓝，并检测脑组织中染料的含量 ...
岳计辉 +6 more
core +1 more source
[Rapid determination of 22 functional components in cosmetics using ultra-high performance liquid chromatography-linear ion trap/orbitrap high resolution mass spectrometry]. [PDF]
Se Pu, 2022 Xiong C +5 more
europepmc +1 more source
[Preparation of modified rosin bonded silica high performance liquid chromatographic stationary phase and separation of Panax notoginseng saponins]. [PDF]
Se Pu, 2022 Xie W +6 more
europepmc +1 more source
[Preparation of branched polyethyleneimine-assisted boric acid-functionalized magnetic nanoparticles and its application to selective enrichment of ginsenoside Re]. [PDF]
Se Pu, 2021 Li X, Yan Z, Li L, Ma T, Chen Y.
europepmc +1 more source
[Determination of nine ginsenosides in health foods by solid extraction phase-ultra performance liquid chromatography-tandem mass spectrometry]. [PDF]
Se Pu, 2021 Chen S, Feng R, Lin X, Liang T, He Q.
europepmc +1 more source
[Hydrophilic interaction liquid chromatography for removal of pesticide residues in ginseng extracts]. [PDF]
Se Pu, 2021 Sun L +6 more
europepmc +1 more source
[Determination of gypenoside XLVI and LVI in Gynostemma pentaphyllum from Fujian by ultra-high performance liquid chromatography-charged aerosol detector]. [PDF]
Se Pu, 2022 Lu P +9 more
europepmc +1 more source