自体原位肝移植术后早期胃氧化损伤及其与NF-E2相关因子2的关系
【目的】 探讨SD大鼠自体原位肝移植后16 h内胃病理学变化特点, 胃黏膜氧化损伤及NF-E2相关因子2(Nrf2)表达的变化。【方法】 将24只SPF级SD大鼠随机均分为假手术组(Sham,n = 6)、自体原位肝移植再灌注后4 h组(R4h)、自体原位肝移植再灌注后8 h组(R8h)和16 h组(R16h)。假手术组在麻醉后只进行开腹和血管的分离,不进行肝脏的阻断和灌注;其余各自体原位肝移植组则进行自体肝移植手术,观察胃组织病理学变化特点、羟自由基(·OH)、丙二醛(MDA)、超氧化物歧化酶(SOD)
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