[Establishment and application of a knowledge-directed pseudo-targeted analytical method for diabetic retinopathy]. [PDF]
Se PuHou YQ +8 more
europepmc +1 more source
[Research progress on the correlation between Akkermansia muciniphila and cardiovascular diseases]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoJiang S, Gong L, Zheng H.
europepmc +1 more source
色素上皮衍生因子PEDF全基因敲除诱导脂肪堆积的 作用及机制
Zhongshan Daxue xuebao. Yixue kexue ban, 2016 摘 要: 【目的】 研究色素上皮衍生因子PEDF表达水平与脂代谢的关系,探讨PEDF参与血脂代谢的可能调控机制,为揭示PEDF参与多种代谢疾病提供重要依据?【方法】 应用Crispr/Cas9基因修饰技术构建PEDF-/-小鼠,高脂饮食(HFD)诱导肥胖小鼠模型,检测小鼠血脂水平(甘油三脂TG?总胆固醇TC?游离脂肪酸FFAs)的变化,实时定量RT-PCR检测脂肪组织中脂肪代谢关键基因(ATGL?PPAR-γ?FAS?HSL)的表达量?【结果】 基因组水平鉴定和蛋白水平检测表明PEDF-/-小鼠构建成功;
doaj
[Analysis of urine biomarkers in urothelial carcinoma based on untargeted metabolomics]. [PDF]
Se PuLiu S, Wang M, Wang W.
europepmc +1 more source
[The role and mechanism of chemokine network in promoting osteoarthritis progression by regulating synovial macrophage heterogeneity]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za ZhiLin Y, Wu L, Chen Q, Shen B.
europepmc +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 1993 肝豆状核变性(WD)的离体培养皮肤成纤维细胞模型可用于WD铜代谢的进一步研究,并有可能提供WD患者早期诊断的有效方法。作者建立了WD患者和对照组各5例的离体培养皮肤成纤维细胞系,并进行了各细胞系在不同代数培养时胞浆内铜含量的测定,为进一步研究该模型打下基础。
doaj
阿立哌唑与奥氮平对首发年轻成人精神分裂症患者短期内代谢风险的比较
Zhongshan Daxue xuebao. Yixue kexue ban, 2011 【目的】比较阿立哌唑与奥氮平对首发年轻成人精神分裂症患者短期内的代谢风险【方法】 采用开放对照的临床观察方法,对符合美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)精神分裂症诊断标准的首发住院精神分裂症患者,分别使用阿立哌唑(21例)和奥氮平(42例)治疗,自然观察时间不低于2周,不大于4周,于治疗前后各检测一次体质量腰围空腹血脂血糖及胰岛素C肽【结果】 观察结束时:阿立哌唑组的体质量体质量指数(BMI)腰围腰臀比均有增高(P < 0.05),糖脂改变无统计学差异,男女患者间各项代谢指标的变化无统计学差异(
doaj
[Spatial omics in pulmonary fibrosis: advancing mechanistic insights and therapeutic strategies]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanPeng Y, Xie Y, Yang F, Qiao X, Tian Y.
europepmc +1 more source
[Liver-bone axis: novel mechanisms and strategies for MAFLD regulation]. [PDF]
Zhonghua Gan Zang Bing Za ZhiWang YW, Yan XZ, You H, Yang AT.
europepmc +1 more source
[Heterogeneity of tumor-associated macrophages and precision targeting strategies in hepatocellular carcinoma]. [PDF]
Zhonghua Gan Zang Bing Za ZhiHuang K, Zhang GQ.
europepmc +1 more source