Results 81 to 90 of about 52,960 (211)

外泌体来源的长链非编码RNA在癌症诊断及治疗中的研究进展

open access: yesZhongguo shiyan zhenduanxue, 2019
外泌体是由脂质双层膜包裹的,含有蛋白质、多肽和核酸的纳米级细胞外囊泡。目前已经从外泌体中鉴定出4563余种蛋白质、194余种脂类、1639余种mRNA、764余种miRNA等非编码RNA (lncRNAs)以及mtDNA、ssDNA和dsDNA等[1,2]。外泌体含有的多种功能性核酸及蛋白质,在细胞物质转运和信息传递过程中发挥重要作用,影响着细胞的生长与分化。近年来研究表明,lncRNA了参与细胞增殖、分化、染色体重塑、表观遗传调控、转录和转录后修饰等多种生物学过程,也引起大家越来越多的关注 ...
薛婷, 姜义, 史莹, 张颖超
doaj  

Scientists in power plays: How substantive were scientists' narratives during the COVID‐19 pandemic?

open access: yesPolicy Studies Journal, EarlyView.
Abstract Scientists who provide expert advice must engage with policy processes. Little is known about whether and how scientists deal with the political dynamics of policy processes that are inherent to policymaking. We study this question by building on the policy dimension concept within the Narrative Policy Framework.
Jule Ksinsik, Caroline Schlaufer
wiley   +1 more source

The pathophysiology of meibomian gland dysfunction related ocular surface diseases and the molecular mechanism [PDF]

open access: yes, 2016
第一部分:睑板腺功能障碍诱导的小鼠干眼动物模型的建立 目的:睑板腺功能障碍(MGD)是引起蒸发过强型干眼最常见的病因,但是MGD引起的眼表面病变的病理生理过程目前还知之甚少。本研究的主要目的是建立蒸发过强型干眼的动物模型,并观察该类型干眼的眼表病理变化过程。 方法:用裂隙灯显微镜观察外异蛋白基因(EctodysplasinA,EDA)突变鼠(Tabby鼠)的眼表病变过程,用荧光素钠染色方法检测Tabby鼠的角膜上皮缺损状况,用酚红棉线检测小鼠的水性泪液分泌,对角膜和眼睑进行H&E染色和油红染色 ...
李三明
core  

Using Cultural Theory to Specify the Policy Actors, Belief Systems, and Sources of Coalition, Conflict, Stability, and Change in Policy Advocacy Coalitions and Environmental Resource Policies

open access: yesPolicy Studies Journal, EarlyView.
ABSTRACT We use grid‐group cultural theory (CT) to specify underspecified aspects of the Advocacy Coalition Framework (ACF). Our theoretical synthesis of CT and the ACF provides, first, an exhaustive typology of policy actors and their cultural cognitive biases that entail, guide, and constrain policy core beliefs about problem definitions and ...
Metodi Sotirov, Brendon Swedlow
wiley   +1 more source

新型户外柱上真空开关

open access: yesGaoya dianqi, 1998
影响真空开关在户外环境下使用的主要因素是外绝缘问题。最早的方法是将真空灭弧室及有关部件置于密闭的箱体内,充变压器油或充绝缘气体作绝缘介质。前者不符合无油化的要求,而后者的生产工艺、维修等则相对复杂。现在一些设计单位已不再在箱体内充油、充气,而将箱体密封,箱体内为干燥空气,使户外开关的灭弧室及有关部件的工作环境由“户外”变为“户内”,这不失为一种可行的方法,但毕竟存在着密封问题。若将户外开关由“箱式”变为“全敞开式”,将更易为用户接受。基于此 ...
金黎, 张猛, 吴玉军, 贾晓胜
doaj  

Effects of FGF on the growth and development of Echinococcus multilocularis and its molecular mechanism [PDF]

open access: yes, 2015
泡状棘球蚴病是由多房棘球绦虫续绦期幼虫引起的一种严重威胁人类生命安全的人兽共患寄生虫病,泡球蚴在宿主体内的生长发育过程受到宿主生长因子的影响。本文在实验室成功构建的泡球蚴体外培养体系的基础上,探讨宿主成纤维生长因子FGF与泡球蚴生长发育的相互关系,并初步阐述了FGF通过调控泡球蚴体内的ERK信号通路影响泡球蚴生长发育的分子机制。本文主要包括以下内容: (1)FGF影响体外培养泡球蚴的生长过程。分别从FGF影响泡球蚴囊泡的存活率、生长率来阐述FGF对于泡球蚴的生长过程的影响。在有血清和无血清培养液中 ...
王亮
core  

Gender Dimensions of Support for Local Policy: Resident, Policymaker, and Policy Gender

open access: yesPolicy Studies Journal, EarlyView.
ABSTRACT There is a well‐established triadic relationship between satisfaction with public services, trust in leaders, and policy support in developed democracies. This study takes a novel approach by considering how gender is associated with the strength and direction of these connections, an element underexplored in the literature.
Aliza Forman‐Rabinovici, Itai Beeri
wiley   +1 more source

Acinetobacter sp.B-126 カブ ノ キンタイ カラ チュウシュツ シタ β-グルコシダーゼ オヨビ α-1,2-マンノシダーゼ ノ セイセイ ト ソノ セイシツ [PDF]

open access: yes, 2000
【緒言】著者らは,以前,Acinetobacter sp. B-126株が,パン酵母細胞を炭素源としたとき, α-マンノシダーゼおよびβ-1,6グルカナーゼを菌体外に生産し,さらに,これらの酵素が酵母の細胞壁多糖の構造解析に有用であることを示した.細菌の菌体外エンド-β-1,3-グルカナーゼはすでにいくつかの報告があるが,酵母のグルカンに作用する細菌のβ-グルコシダーゼの報告は少ない.一方,酵母マンナンに作用する細菌の菌体外α-マンノシダーゼは多くの報告がある.しかし ...
三浦 里美   +2 more
core   +1 more source

The Inclusion Trade‐Off: Comparing the Design and Functionality of Collaborative Governance Forums

open access: yesPolicy Studies Journal, EarlyView.
ABSTRACT Environmental challenges require collaboration across jurisdictions, often through forums or intermediary spaces for repeated interaction. A persistent forum design question concerns inclusion criteria, or which actors should be included.
Adam Wiechman   +3 more
wiley   +1 more source

The research of developing functional artery with collateral circulation in the ischemic hindlimb [PDF]

open access: yes, 2016
1、背景与目的 随着社会的发展,血管方面疾病的发病率呈现日益增高的趋势。在众多血管疾病中动脉硬化闭塞症、血栓闭塞性脉管炎等这一类疾病均可能伴随出现下肢缺血的症状。其中手术治疗主要包括人造血管旁路移植、支架植入以及球囊成形术等,但血管移植通常会形成血栓而只有短期的通畅性,支架植入和血管成形术往往又会造成扩张部位的再狭窄。对于血管病变广泛而无法进行手术或腔内治疗的患者,就只能通过药物保守治疗,通常是采用扩血管、抗凝和抗血小板等方法来改善其血液供应,随着病程的发展,药物往往不能起到很好的效果 ...
周旭
core  

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