Results 141 to 150 of about 28,669 (212)
The Role of Cdk5 in neuronal death and synaptic dysfunctions through phosphorylating FOXO1 and BAG3 [PDF]
, 2016 细胞周期蛋白依赖性激酶5（Cyclin-dependentkinase5，Cdk5）是由脯氨酸介导的丝氨酸/苏氨酸蛋白激酶，其在神经系统中发挥着重要的作用。Cdk5的活化主要靠神经系统中广泛表达的两个激活因子p35和p39。Cdk5对神经系统的正常生理功能具有重要作用去，其可通过磷酸化众多底物的丝氨酸/苏氨酸位点，在神经元的迁移分化，突触传递，轴突树突的发育过程以及神经元的存活中都发挥着重要的作用。此外，在某些病理条件下，Calpain所介导的p35切割形成p25，可以过度激活Cdk5 ...
周杰超
core
Review of Policy Research, EarlyView.ABSTRACT Public appointments shape the top‐level bureaucracy by serving as a gateway for professionals with different profiles, chosen based on different criteria. In general, the literature has been more interested in analyzing appointments based on merit or sponsorship, based on verification of loyalty to the government or technical competence ...
André Vaz Lopes +1 more
wiley +1 more source
Gaoya dianqi, 2015 为了抑制真空断路器分闸操作过程的触头过冲与反弹现象,提高断路器的开断性能,笔者基于真空断路器永磁机构分闸操作工作原理,分析触头的运动过程,获取有效抑制触头过冲与反弹的预设行程值,建立了触头在分闸位置的速度特性与过冲及反弹幅值的特征关系。利用闭环控制策略对永磁机构线圈电流进行调节,降低触头的分闸末速度,实现对触头过冲与反弹的有效抑制。研制以数字信号处理器（DSP）为核心的控制装置,开展12 kV真空断路器永磁机构分闸操作实验,对操作过程中触头行程数据进行对比分析。结果表明,在上述控制系统的作用下 ...
徐建源, 雷伟, 汤庚, 史可鉴
doaj
Review of Policy Research, EarlyView.ABSTRACT Using data from a long‐term survey of senior civil servants (1970–2021), this study investigates the declining share of jurists in federal ministerial departments in Germany. The mechanisms driving this trend and its subsequent effects are discussed from an organizational perspective, highlighting the influence of environmental pressure and ...
Marian Döhler
wiley +1 more source
Gaoya dianqi, 2003 针对12,40.5kV和72.5kV户内、外真空断路器,研究开发了永磁操动机构设计与分析软件。该软件工作于Windows操作系统平台,适用于单、双稳态两种结构与直流和电容两种供电方式的永磁操动机构的机械和电磁设计以及相应的电子控制部分设计。可以仅仅根据用户给出的几个主要技术参数要求,完全自动地进行永磁机构的结构参数设计、静态和动态电磁和机械特性的计算、电子控制线路和元件的设计、可变参数的机械零件和装配图的绘制、产品技术文件生成等的工作。
李岩 +4 more
doaj
Non‐Members in a Tight Spot: How Norway Navigated Autonomy in EU Pandemic Management
Review of Policy Research, EarlyView.ABSTRACT This study offers new insights into how closely integrated non‐member states navigate tensions between autonomy and dependence when urgent policy responses are required within complex supranational frameworks. It does so by exploring how these non‐members exercise their “wriggle room”—a tailored sub‐category of the broader concept of autonomy ...
Sjoerd Alexander de Winter
wiley +1 more source
Dianci bileiqi, 1984 1978～1980年,结合科研工作,我们对国内各主要电瓷生产厂使用的起骨干作用的真空练泥机的型式、规格和基本参数以及挤制工况进行了调查和测定.通过这一工作 ...
陈嘉明
doaj
ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis
Veterinary Dermatology, EarlyView.ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake +2 more
wiley +1 more source
Gaoya dianqi, 2018 针对断路器底盘车机械寿命试验采用人力操作耗时长、费力多等问题,设计了一种全自动断路器底盘车机械寿命试验系统。该系统由支架单元、控制系统和可拆卸连接轴套装置组成,采用伺服控制原理实现断路器底盘车机械操作摇入摇出的自动运行及控制,可根据旋转圈数、动作时间或辅助开关状态信号对工作位置/试验位置进行精准判定,并可依据扭矩、旋转圈数以及动作时间进行多重保护,适用于各种型号的中置式高压开关柜。实验结果表明,该系统从根本上解决了机械寿命试验中人力操作耗时长、易受不稳定因素影响等问题,极大的提高了试验效率 ...
兰剑 +5 more
doaj
A Tale of Two Programs? Stigma and Administrative Burdens in CHIP and Medicaid
World Medical &Health Policy, Volume 18, Issue 1, March 2026.ABSTRACT One contributing factor to undersubscriptions is administrative burdens. To explore whether program stigma affects attitudes about administrative burdens, a survey (N = 2204) was fielded to assess differences in attitudes about seven policies decreasing administrative burdens and two policies increasing administrative burdens.
Simon F. Haeder
wiley +1 more source