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LGBTQIA+ victimization: A theoretical discourse

open access: yesSexuality, Gender &Policy, Volume 6, Issue 4, Page 253-262, November 2023., 2023
Abstract This paper draws on social construction and broken window theories as theoretical frameworks to explain how LGBTQIA+ are victimized due to discrimination and nonacceptance in their communities. Homosexual groups face a high risk of violence, discrimination, and prejudice because of their sexual orientation.
Ephraim Kevin Sibanyoni   +2 more
wiley   +1 more source

A case series of canine cutaneous inverted papilloma with one case showing evidence of recurrence

open access: yesVeterinary Dermatology, Volume 32, Issue 3, Page 268-e74, June 2021., 2021
Background – This article describes a case of multiple, recurrent, cutaneous inverted papillomas (CIPs) in a German shepherd dog, combined with a retrospective follow‐up assessment of eight cases. Methods – A 3‐year‐old, black, female German shepherd dog presented with four rapidly growing, alopecic, domed, hyperpigmented, shiny nodules, compatible ...
Teresa M.S.A. Boehm   +5 more
wiley   +1 more source

Arbuscular mycorrhizal fungus reshapes the rhizosphere microbiome of alfalfa in response to above‐ground attack by aphids and a fungal plant pathogen

open access: yesFunctional Ecology, Volume 39, Issue 8, Page 2149-2169, August 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Plants assemble beneficial rhizosphere microbiomes through a ‘cry for help’ mechanism upon pathogen or insect herbivore attack. The arbuscular mycorrhizal fungi (AMF) can influence the composition of microbial communities in the plant rhizosphere. However, their impacts
Yingde Li   +6 more
wiley   +1 more source

EFNA4 Effecting On EphA2 Regulates Cell Adhesion And Metastasis In Breast Cancer [PDF]

open access: yes, 2016
实验背景:肿瘤细胞对临近组织和器官的侵袭与远端转移,一直是肿瘤研究的热点。酪氨酸受体蛋白及其配体家族Ephs和Ephrins之间的作用被证实能够调控多种肿瘤细胞的形态,细胞骨架,进而影响细胞的迁移与转移。前期通过荧光定量RT-PCR,我们发现相对于正常组织来源的细胞系,EFNA4在乳腺癌和肝癌细胞系中表达较低。同时在建立的高低侵袭ZR-75-30乳腺癌细胞系中,EFNA4具有表达差异,而EFNA4在肿瘤中的作用鲜有报道。 实验方法与结果:在体外实验中 ...
王恒
core  

Effects of Treponema pallidum on THP-1 derived macrophage polarization [PDF]

open access: yes, 2015
梅毒螺旋体(Treponemapallidum)是性传播疾病梅毒的致病菌,尽管有关T.pallidum的研究已经开展近一个多世纪,对其生物学及病原学特性有了一定的了解,然而对于T.pallidum致病机制的认识还处于起步阶段。巨噬细胞作为机体防御外来病原体的第一道防线,在对T.pallidum的识别、吞噬、抗原提呈、杀伤等方面均发挥着重要作用。随着对巨噬细胞研究不断深入,有学者将巨噬细胞分为两种不同的极化类型,即促进炎症发展的M1型巨噬细胞和在抑制炎症反应及组织修复等方面发挥作用的M2型巨噬细胞 ...
席亚
core  

A preliminary study on Wee1 kinase protein stability in fission yeast [PDF]

open access: yes, 2016
Wee1作为真核生物中调控细胞有丝分裂G2/M期过渡的重要激酶,它的功能可以被Cdc25磷酸酶所拮抗。如果细胞中的Wee1蛋白水平或者活性过高,细胞进入有丝分裂期延迟;而反之则G2期缩短,细胞提前进入有丝分裂期,因此在整个细胞周期中Wee1受到了非常精细地调控。高等生物中的研究表明,Wee1蛋白水平和稳定性受到了SCF的调控。为了研究裂殖酵母中参与调控Wee1激酶蛋白水平的细胞因子,本研究以裂殖酵母这一经典的单细胞真核生物为模式生物,开展了对有丝分裂G2/M过渡时期参与调控Wee1蛋白水平的因子的研究。
邱翠
core  

A study about the impact of overpression of Oct4 and Sox2 gene on gastric cancer cell biology and oncology characteristics [PDF]

open access: yes, 2015
目的:通过构建过表达干细胞因子Oct4和Sox2的胃癌SGC7901细胞株,研究过表达干细胞因子Oct4和Sox2对SGC7901胃癌细胞干细胞特性、肿瘤学特性、及生物学特性的影响,并探讨Oct4及Sox2在肿瘤细胞中的作用机制。 方法:1.构建携带Sox2基因的重组质粒,慢病毒载体感染SGC7901-OCT4细胞株得到SGC7901-OCT4-SOX2稳转细胞株。2.利用荧光定量PCR、western–bloting检测过表达Oct4及Sox2的胃癌SGC7901细胞中胃癌干细胞标志基因表达情况。3 ...
李文鹏
core  

垂体腺瘤中CD147、LN-R基因蛋白的表达与侵袭性的关系

open access: yesZhongguo shiyan zhenduanxue, 2009
目的探讨CD147、LN-R的表达与侵袭性垂体腺瘤的关系。方法用免疫组织化学方法对60例垂体瘤患者组织标本CD147、LN-R的表达进行检测。免疫组化结果用半定量的方法进行分析。结果60例垂体瘤患者中,32例女性,28例男性。其中,30例为侵袭性垂体腺瘤,30例为非侵袭性垂体腺瘤。免疫组化显示侵袭性垂体腺瘤的CD147、LN-R的表达明显高于非侵袭性垂体腺瘤 ...
张慧, 郭永川, 钟艳平
doaj  

Regulation of PI3K and MAPK inhibitors on the activity of FOXO1 and their effect on biological behavior of GIST-T1 gastric stromal tumor cell lines [PDF]

open access: yes, 2015
胃肠道间质瘤(gastrointestinalstromaltumors,GISTs)是消化道最常见的间叶组织肿瘤。目前普遍认为GISTs起源于向cajal细胞分化的原始间叶细胞或幼稚干细胞,具有多向分化特征,可以向平滑肌、神经分化或不定向分化,是一种具有恶性潜能的胃肠道肿瘤,但其确切起源尚不明确。其发病率为1~2/10万人口,似乎正逐渐增加。近年来有研究表明,PI3K(磷脂酰肌醇-3-激酶)和MAPK(丝裂原活化蛋白激酶)信号通路活性在胃肠道间质瘤显著增高 ...
高华
core  

uPA、PAI-1、bFGF的表达和MVD计数与垂体腺瘤侵袭性的关系

open access: yesZhongguo shiyan zhenduanxue, 2008
目的探讨尿激酶型纤溶酶原激活因子(uPA)及其抑制因子(PAI-1)、碱性成纤维细胞生长因子(bFGF)的表达和血管形成与垂体腺瘤侵袭性的关系。方法选取垂体腺瘤手术标本41例,分为侵袭组21例,非侵袭组20例,正常垂体标本5例。采用免疫组化法检测uPA、PAI-1、bFGF在各组中的表达并进行微血管记数。结果uPA、PAI-1、bFGF在侵袭组表达阳性率明显高于非侵袭组,两组比较有显著性差异 ...
苗壮, 董震, 赵兴利, 高荫荣
doaj  

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