Results 41 to 50 of about 18,949 (162)

Association between Polymorphisms of ERCC1 and Response in Patients with Advanced Non-small Cell Lung Cancer Receiving Cisplatin-based Chemotherapy [PDF]

open access: yes, 2010
Background and objective Results of studies on genetic polymorphisms of ERCC1 gene in DNA repair pathway which may affect response to platinum-based chemotherapy and survival in patients with non-small cell lung cancer are conflicting.
Hui ZHANG   +6 more
core  

USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2 [PDF]

open access: yes, 2015
蛋白泛素化/去泛素化修饰的异常与多种肿瘤的发生存在密切相关。作为去泛素化酶家族中的重要一员,USP4在一些肺癌细胞及其它人类癌细胞中呈现出高表达,说明USP4可能作为癌蛋白(oncoprotein)参与到对肿瘤细胞发生发展的调控。而目前对USP4参与肿瘤细胞发生的分子机制尚不清楚。我们的前期研究发现,USP4可以与去乙酰基转移酶HDAC2结合。初步研究表明USP4可以去泛素化并稳定HDAC2。进一步的研究发现,USP4通过HDAC2抑制p53的转录活性及NF-κB信号通路。在本项申请中 ...
李增鹏
core   +1 more source

Mitigation of Legacy Effects in Invaded Soil via Alien Plant‐Derived Biochar 题目:外来植物生物炭对其入侵后土壤遗留效应的修复作用

open access: yesIntegrative Conservation, Volume 4, Issue 4, Page 686-694, December 2025.
The soil fungicide reduces the occurrence of pathogenic fungi in invaded soil and at the same time promotes the recruitment of mycorrhizal fungi and saprophytic fungi by the plants. The addition of biochar to the invaded soil has a negative legacy effect on subsequent invasive plants, while it exerts a positive enhancement effect on native plants ...
Weitao Li   +5 more
wiley   +1 more source

Brånemark 种植义齿修复全牙列缺失的近期临床评价

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2000
【目的】评价Brå nemark 种植义齿修复全牙列缺失2 年后的临床效果。【方法】采用Brå nemark 种植系统的常规 操作方法, 在Ⅰ 期手术时, 354 颗Brå nemark 种植体被植入全牙列缺失的66 例患者;4 ~ 6 个月后, 进行Ⅱ 期手术;再经1 周后, 用固定可卸式修复体修复。【结果】Brå nemark 种植体修复后2 年, 累积成功率上颌为91.1%, 下颌为97.4 %, 修复体的稳定 率为100%。【结论】Brå nemark ...
邓飞龙   +3 more
doaj  

上海曹扬环浜污染水体的生态修复 [PDF]

open access: yes, 2005
曹扬环浜是一条环形封闭水道,水质低于地表水V类标准,水体处于严重超富营养化水平,全浜暴发蓝藻水华现象。在采用截污、造流、生态恢复等生态工程措施综合治理后,随着健康水生态系统的建立,河浜水质逐步变好(由劣V类改善为接近Ⅲ类标准),水体透明见底,沉水植物覆盖率达70%~90%,水体一直维持“清水草型稳态”。重点介绍了河道治理中采用的生态修复措施及其作用,并从截污、营养盐、水生生物等方面分析了各项工程措施对抑制藻类生长、水质改善的影响 ...
方涛,王春树,陈洪达,李敦海,刘永定
core  

Relocating Citizens From Urban Environments Exposed to Hazardous Levels of Contamination: A Rapid Scoping Review

open access: yesRisk, Hazards &Crisis in Public Policy, Volume 16, Issue 4, December 2025.
ABSTRACT Background Hazardous levels of contaminants produced by anthropogenic activities are increasingly pervading residential environs and urban areas. Hazardous contamination can pose significant health risks for citizens dwelling in exposure pathways.
Rosina Johnson   +3 more
wiley   +1 more source

比较不同抗原修复液对免疫组化结果的影响

open access: yesZhongguo shiyan zhenduanxue, 2015
免疫组织化学(Immunohistochemistry,IHC)是一种通过抗原抗体特异性反应来检测并定位蛋白的方法,目前广泛应用于组织病理学诊断[1]。抗原修复是免疫组化实验中的关键步骤,已有文献针对现有的修复方式做了一个初步的比较,结果显示微波高压修复、微波热修复以及高压热修复在相同的条件下具有相似的结果[2]。然而,抗原修复过程中选择不同的缓冲液 ...
王琦   +5 more
doaj  

Marine Ecological Damage Assessment and Compensation: Theory, Approaches and Case Studies [PDF]

open access: yes, 2015
海洋生态系统是地球生命支持系统之一,也是支撑人类生存和发展的重要资源宝库,对于人类经济的繁荣和生活质量的提高贡献巨大。然而,随着人类对海洋开发进程的加快,海洋环境与海洋生态系统面临着越来越大的压力,海洋资源利用冲突、海洋环境质量退化和生态破坏问题日益凸显。建立海洋生态损害补偿机制被认为是解决海洋资源利用冲突,保护海洋环境和生态系统永续发展的有效途径之一,而海洋生态损害补偿理论和方法的研究则是其重要的前提。目前,生态补偿的研究与实践多集中在陆域生态系统,涉海方面的研究尚不多见 ...
饶欢欢
core  

A Conservation Assessment and Systematic Review of the Endangered Spectacled Flying‐Fox 濒危眼镜狐蝠的保护评估与系统综述

open access: yesWildlife Letters, Volume 3, Issue 4, Page 173-193, December 2025.
Spectacled flying‐fox Pteropus conspicillatus populations have declined so seriously over two decades that they are now endangered. Inaction has allowed threats to increase. Extreme heat events are now a lethal reality, habitat loss continues almost unabated, and pressure to disperse roosts is ever‐present. Obtaining resources and taking action to help
Noel Preece
wiley   +1 more source

Construction and immobilization of petroleum-degrading consortium [PDF]

open access: yes, 2012
近年来,随着海洋资源的开发和利用,海洋受到了严重的污染,其中石油污染尤为突出。海上石油及其产品污染是最重要的生态学灾难性污染之一,海洋石油开采和管道化以及商船运输都是潜在的流动污染源。以微生物为主体的生物修复技术以其投入小、无二次污染的优势被视为最有前途的治理手段。但低水温、寡营养以及海水的冲刷等因素都会直接影响微生物降解石油的效率,加之石油组分的复杂性,使得海洋石油污染的生物修复技术较之其他的生物修复技术更为复杂。本研究针对海洋石油污染治理技术研究领域的难点,开展了石油降解菌的定向驯化 ...
郭倩
core  

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