Results 11 to 20 of about 12,131 (156)

Detection of MTAP Protein and Gene Expression in Non-small Cell Lung Cancer [PDF]

open access: yes, 2011
Background and objective The abnormal expression of MTAP, a tumor suppressor gene, is found in a variety of tumor tissues. The aim of this study is to detect the expression of MTAP mRNA protein and the clinical significance for the therapy of non-small ...
Baoqing DING   +3 more
core  

Evaluation of filaggrin 2 expression in dogs with atopic dermatitis before and after oclacitinib maleate administration

open access: yesVeterinary Dermatology, Volume 36, Issue 4, Page 453-461, August 2025.
Background – Canine atopic dermatitis (cAD) is a chronic, inflammatory, multifactorial and pruritic disease. The presence of skin barrier impairment (e.g. filaggrin alterations), along with abnormal immune responses, can negatively impact cutaneous barrier function.
Wendie Roldan Villalobos   +5 more
wiley   +1 more source

Preparation and Characterization of Semaphorin3Fc Monoclonal Antibody and the Preliminary Application [PDF]

open access: yes, 2015
研究背景和目的 抑癌基因发生异常是癌症发生的机制之一。人类基因的很多区域发生改变时可导致细胞失控性生长。Sema3F作为肺癌19个候选抑癌基因之一,是Ⅲ型Semaphorin(即神经导向因子,最初作为Neuropilins的配体在神经系统中发挥排斥神经节轴突和调节神经系统发育的作用)家族的一个成员。目前有研究发现,与正常组织相比Sema3F蛋白在肿瘤细胞中的表达普遍存在下调的趋势,并在血管形成以及肿瘤增殖、凋亡、粘附和转移等中起着负向调节作用。此外,诸多体内或者体外实验已经证明 ...
李哲
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Preparation and Characterization of Anti-Neuropilin2 Monoclonal Antibody and Its Preliminary Application [PDF]

open access: yes, 2016
研究背景和目的 Neuropilin2(NRP2)是一种多功能的新型受体,在神经系统发育、心血管系统、免疫系统及淋巴管生成等过程中发挥重要作用。最新研究表明,NRP2受体广泛表达于肿瘤细胞表面,与肿瘤血管形成以及肿瘤的发生发展、凋亡、粘附、侵袭和转移等生物学行为密切相关。多种肿瘤细胞均高表达NRP2,提示NRP2可能成为一种新型肿瘤标志物。NRP2通过多种机制调控肿瘤进展,NRP2-b1b2是其发挥作用的重要结构域,NRP2-b1b2结构域可以结合配体Ⅲ型Semaphorin和VEGF ...
杨芸
core  

Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer [PDF]

open access: yes, 2011
Background and objective uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer ...
Boshi WANG   +7 more
core  

Hyalinizing clear cell carcinoma of salivary gland: a clinicopathological study of 8 cases [PDF]

open access: yes, 2023
Background and purpose: Hyalinizing clear cell carcinoma (HCCC) of salivary gland is a rare tumor with low-grade malignancy, which usually occurs in minor salivary glands.
ZHANG Yan, WANG Zheng, CHEN Tongzhen, BAI Qianming, LI Xiaoqiu
core   +1 more source

免疫组化在临床诊断中的作用 附视频

open access: yesZhongguo shiyan zhenduanxue, 1998
免疫组化在临床诊断中的作用纪小龙王淑琴李红芬免疫组织化学(immunohistochemistry,免疫组化)虽然已出现50多年了,但广泛应用于病理常规诊断仅是近10余年的事。根据组织和细胞内化学成分的不同而建立的特殊染色法,以在大体及组织学水平上找...
纪小龙   +3 more
doaj  

Establishment and Application of Respiratory Syncytial Virus Animal Model [PDF]

open access: yes, 2016
人呼吸道合胞病毒(HumanRespiratorySyncytiaVirus,hRSV)是全球范围内引起下呼吸道感染主要病原体之一。其感染人群年龄分布广,新生儿与老年人是主要高危人群。据报道,几乎所有小于2周岁婴幼儿都有RSV感染经历,婴幼儿发病住院率高达2.5-4%。RSV引起大于65周岁的老年人感染率为3-4%,病死率约为2%。早产儿、先天性心脏病、先天性支气管及肺发育不良、免疫缺陷的婴幼儿RSV病死率率高达5%,造成严重的医疗负担。 RSV无安全、有效疫苗上市 ...
詹炉停
core  

免疫组化在临床诊断中的作用

open access: yesZhongguo shiyan zhenduanxue, 1998
免疫组化在临床诊断中的作用纪小龙王淑琴李红芬免疫组织化学(immunohistochemistry,免疫组化)虽然已出现50多年了,但广泛应用于病理常规诊断仅是近10余年的事。根据组织和细胞内化学成分的不同而建立的特殊染色法,以在大体及组织学水平上找...
纪小龙, 王淑琴, 李红芬
doaj  

Preliminary Studies of Neuropilin-1 Expression on HCC and Inhibitive Effect of Anti-NRP-1 Monoclonal Antibody on HCC Growth [PDF]

open access: yes, 2015
摘要 研究背景和目的 肝癌是世界上最常见的恶性肿瘤之一,男性与女性中肝癌诊断率分别为世界第五和第七,男性及女性肝癌相关死亡率在癌症相关死亡中分别居第二和第六。肝细胞癌占所有肝癌的70%-85%,其诊断和治疗取决于多方面因素——肿瘤的大小,范围,全身和肝功能情况。早期确诊的肝癌患者,才有可能接受肝脏切除或移植等治疗。然而仅有10%-30%的肝细胞癌患者适合根治性治疗,大多数肝细胞癌患者,确诊时已经处于中晚期,无法行根治性治疗,且预后较差。而传统的介入治疗、放化疗存在抗肿瘤效果较差、副作用大等缺点 ...
张亚飞
core  

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