蛋白尿的发生不仅是肾脏损伤的显著标志,大量蛋白尿的持续存在还是预示肾脏病进展的重要因素。因此,蛋白尿水平是评估肾脏病疗效及预后的重要指标之一。传统的观点将肾小球滤过屏障简单地理解为3个层面的结构,目前认为至少由5层结构组成,由内而外分别是内皮细胞表面膜结构、内皮细胞及内皮细胞窗孔、肾小球基底膜(GBM)、足细胞下间隙和足细胞[1]。足细胞是构成肾小球滤过膜的最后一道屏障,其功能受损已被证实是蛋白尿发生的关键环节 ...
吕琴
doaj
目的利用原子力显微镜(AFM)原位观察正常新西兰白兔主动脉和主动脉瓣膜内皮细胞表面超微结构。方法取10只正常健康雄性新西兰白兔的新鲜主动脉和主动脉瓣膜组织,经磷酸盐缓冲液去除组织表面杂质后,置于1%的甲醛溶液中固定。在大体显微镜下,将固定好的主动脉和瓣膜组织粘附并展平在粘着有双面胶的载玻片上,并将主动脉的内膜面和主动脉瓣膜的动脉面置于上部,待样本干燥后,将其置于NanoScope IIIa AFM载物台上,选择其中某个区域,在Tapping模式下进行扫描 ...
尹彤 +6 more
doaj
[Astragaloside IV alleviates D-GAL-induced endothelial cell senescence by promoting mitochondrial autophagy via inhibiting the PINK1/Parkin pathway]. [PDF]
Yi M +6 more
europepmc +1 more source
[Indole-3-acetic acid alleviates <i>Cryptococcus neoformans</i>-induced pyroptosis in cerebral microvascular endothelial cells by regulating stress granule-mediated NLRP3 inflammasome activation]. [PDF]
Chen J +5 more
europepmc +1 more source
[Berberine ameliorates coronary artery endothelial cell injury in Kawasaki disease through complement and coagulation cascades]. [PDF]
Liao JW, Guo X, Liang B, Li XX, Xu MG.
europepmc +1 more source
[Phosphoproteomic analysis of human umbilical venous endothelial cells with DENV-2 infection]. [PDF]
Hu P +6 more
europepmc +1 more source
【目的】 探讨雌二醇(E2)及雌酮(E1)对体外培养的人子宫内膜腺上皮细胞及间质细胞间隙连接细胞间通讯(GJIC)及连接蛋白(Cx)43?32表达的影响?【方法】 采用划痕染料标记示踪技术及激光共聚焦显微镜扫描技术(LSCM),观察E2及E1对原代培养的20例人子宫内膜腺上皮细胞及间质细胞GJIC的影响,采用激光共聚焦显微镜扫描技术,观察E2及E1对Cx 43?Cx 32表达的影响?【结果】 5 × 10-5 mol/L雌二醇作用48 h后间质细胞及腺上皮细胞GJIC功能没有明显变化(P > 0.05),
doaj
[FGF19 alleviates inflammatory injury in vascular endothelial cells by activating the Nrf2/HO-1 signaling pathway]. [PDF]
Zhang YJ +6 more
europepmc +1 more source
Effects of hirudin for the thrombin-induced expression of adhesive molecules in neutrophils and human umbilical vein endothelial cells [PDF]
Cui, LQ +4 more
core
[Mechanism of tetramethylpyrazine attenuates inflammatory injury in endothelial cells by activating the SIRT1 signaling pathway]. [PDF]
Chen LP +5 more
europepmc +1 more source

