Results 11 to 20 of about 18,045 (167)

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang, Rui Wei, Xiaona Cui, Zongzhe Jiang, Jin Yang, Lingyun Zu, Tianpei Hong   +6 more
wiley   +1 more source

Successful surgical removal of a pheochromocytoma in a mare via trans‐costal approach

Equine Veterinary Journal, Volume 55, Issue 6, Page 1012-1020, November 2023., 2023
Abstract Background Pheochromocytomas have been previously reported in horses, but successful antemortem diagnosis and surgical removal without recurrence of clinical signs have not been described. Objective To report the clinical presentation, diagnostic evaluation, surgical technique, anaesthetic management and post‐operative care of a mare diagnosed
Thomas J. O'Brien, Lynn M. Pezzanite, Elizabeth V. Acutt, Allison C. Vilander, Diana M. Hassel, Rachel C. Hector, Dean A. Hendrickson   +6 more
wiley   +1 more source

Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy 纳豆激酶对糖尿病视网膜病变微血管病变和神经炎症的保护作用

Journal of Diabetes, Volume 15, Issue 10, Page 866-880, October 2023., 2023
Highlights Nattokinase rescued endothelial dysfunction and pericyte loss in the diabetic retina. Nattokinase attenuated diabetes‐induced retinal inflammation and neurodegeneration. High mobility group box 1 signaling was involved in nattokinase‐mediated retinal protection.
Zijing Huang, Wai Kit Chu, Tsz Kin Ng, Shaolang Chen, Jiajian Liang, Chong‐Bo Chen, Yanxuan Xu, Biyao Xie, Shuping Ke, Qingping Liu, Weiqi Chen, Dingguo Huang   +11 more
wiley   +1 more source

Canine melanocytes: Immunohistochemical expression of melanocytic markers in different somatic areas

Veterinary Dermatology, Volume 34, Issue 4, Page 284-297, August 2023., 2023
Background – Melanoblasts originate in the neural crest from where they migrate to peripheral tissues and differentiate into melanocytes. Alteration during melanocyte development and life can cause different diseases, ranging from pigmentary disorders and decreased visual and auditory functions, to tumours such as melanoma.
Ilaria Porcellato, Margherita Orlandi, Adriana Lo Giudice, Monica Sforna, Luca Mechelli, Chiara Brachelente   +5 more
wiley   +1 more source

Mechanisms of diabetic foot ulceration: A review 糖尿病足溃疡发生机制综述

Journal of Diabetes, Volume 15, Issue 4, Page 299-312, April 2023., 2023
Highlights With the increase in the elderly population, diabetic foot ulcers (DFUs) severely affect human health and societies worldwide. They will pose significant medical, social, and socioeconomic challenges. Reviewing the existing studies on the pathogenesis of DFUs, most of them focus on clinical nursing and treatment.
Haibo Deng, Binghui Li, Qian Shen, Chenchen Zhang, Liwen Kuang, Ran Chen, SiYuan Wang, ZhiQiang Ma, Gongchi Li   +8 more
wiley   +1 more source

Effective treatment of canine chronic cutaneous lupus erythematosus variants with oclacitinib: Seven cases

Veterinary Dermatology, Volume 34, Issue 1, Page 53-58, February 2023., 2023
Background – The treatment of canine chronic cutaneous lupus erythematosus (CCLE) variants generally requires immunosuppression, which often results in potentially severe adverse effects. Janus kinase inhibitors, like oclacitinib, might be a valuable treatment option due to their rapid inhibition of the action of interferons known to be relevant in the
Richard G. Harvey, Alla Olivrī, Tatiana Lima, Thierry Olivry   +3 more
wiley   +1 more source

Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease 2型糖尿病患者表皮功能的变化及其对治疗的意义

Journal of Diabetes, Volume 14, Issue 9, Page 586-595, September 2022., 2022
Highlights Individuals with type 2 diabetes display epidermal dysfunction. Epidermal dysfunction can provoke cutaneous and extracutaneous inflammation. Because of the pathogenic role of inflammation in type 2 diabetes, improvements in epidermal functions could benefit type 2 diabetes.
Mao‐Qiang Man, Joan S. Wakefield, Theodora M. Mauro, Peter M. Elias   +3 more
wiley   +1 more source

Pseudomonas aeruginosa isolation from dog grooming products used by private owners or by professional pet grooming salons: prevalence and risk factors

Veterinary Dermatology, Volume 33, Issue 4, Page 316-e73, August 2022., 2022
Abstract Background Pseudomonas aeruginosa is the most commonly isolated bacterium from skin lesions of dogs with post‐grooming furunculosis (PGF). It is frequently found in human hair and skin care products, and may pose a health risk to consumers. Information regarding the prevalence of P. aeruginosa contamination of dog grooming products is lacking.
Elad Perry, Gila Abells Sutton, Lotem Haggag, Marcelo Fleker, Shlomo Eduardo Blum, Ronnie Kaufmann   +5 more
wiley   +1 more source

Effects of SGLT2 inhibitors on patients with diabetic kidney disease: A preliminary study on the basis of podocyturia SGLT2抑制剂对糖尿病肾病患者的影响:基于尿足细胞的初步研究

Journal of Diabetes, Volume 14, Issue 4, Page 236-246, April 2022., 2022
Highlights Diabetic kidney disease is a progressive disease with the pathology of glomerular damage and loss of podocytes. Sodium glucose cotransporter 2 inhibitors (SGLT2i) can be expected to decrease the amount of podocyte excretion. Male patients receiving SGLT2i have better diabetic kidney disease‐related parameters and podocyturia levels. Abstract
Emre Durcan, Serbay Ozkan, Halil Ibrahim Saygi, Mevlut Tamer Dincer, Ozge Polat Korkmaz, Serdar Sahin, Cebrail Karaca, Cem Sulu, Alev Bakir, Hande Mefkure Ozkaya, Sinan Trabulus, Elif Guzel, Nurhan Seyahi, Mustafa Sait Gonen   +13 more
wiley   +1 more source

Onset and duration of action of lokivetmab in a canine model of IL‐31 induced pruritus

Veterinary Dermatology, Volume 32, Issue 6, Page 681-e182, December 2021., 2021
Onset of antipruritic action of lokivetmab in dogs. Laboratory‐bred beagle dogs were dosed subcutaneously with either placebo or lokivetmab at 2.0 mg/kg on Day (D) 0. Approximately 2.5 h post‐dosing, pruritus was induced using canine interleukin (IL)‐31. Animals were observed for pruritic behaviours for a total of 2 h (3–5 h post‐treatment with placebo
Timothy J. Fleck, Lori R. Norris, Sean Mahabir, Rodney R. Walters, Olivier Martinon, Steven A. Dunham, Andrea J. Gonzales   +6 more
wiley   +1 more source