Results 101 to 110 of about 5,220 (146)

[Ameliorative effects and mechanisms of an integrated endoplasmic reticulum stress inhibitor on lipopolysaccharide-induced cognitive impairment in mice]. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Liu D, Liu W, Xie L, Xu X, Zhong X, Cao W, Xu Y, Chen L.   +7 more
europepmc   +1 more source

内质网应激通过抑制PI3K/AKT/mTOR信号通路诱导多形性胶质母细胞瘤干细胞凋亡的机制

Zhongshan Daxue xuebao. Yixue kexue ban, 2016
摘 要: 【目的】 探索内质网应激(ER stress)通过抑制PI3K/AKT/mTOR信号通路诱导多形性胶质母细胞瘤肿瘤干细胞(GSC)凋亡的机制?【方法】 临床获取多形性胶质母细胞瘤肿瘤组织标本,剪碎?胰酶消化?过滤?去除红细胞后,培养GSC;免疫荧光技术检测GSC抗原CD133?GFAP? Nestin?
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[Cannabidiol inhibits neuronal endoplasmic reticulum stress and apoptosis in rats with multiple concussions by regulating the PERK-eIF2α-ATF4-CHOP pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Yang Y, Yang L, Wu Y, Duan Z, Yu C, Wu C, Yu J, Yang L.   +7 more
europepmc   +1 more source

蛋白酶体抑制剂Epoxomicin对视网膜色素上皮细胞 自噬-溶酶体途径的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2016
摘 要: 【目的】 研究抑制泛素-蛋白酶体途径(UPP)对自噬-溶酶体途径(ALP)的影响及相关作用机制?【方法】 人视网膜色素上皮细胞系ARPE-19共分为3组,分别为DMEM空白对照组?DMEM+DMSO阴性对照组?DMEM+Epoxomicin实验组?应用蛋白免疫印迹法和细胞免疫荧光法检测泛素化蛋白的表达,观察UPP功能的改变情况;观察LC3,LAMP1?LAMP2的表达,评价自噬作用和溶酶体的功能变化情况;观察HDAC6,p62的表达,初步探索UPP抑制对ALP改变的分子机制?【结果 ...
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[Huangqin Decoction alleviates ulcerative colitis in mice by reducing endoplasmic reticulum stress]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Qiu J, Qiu Y, Li G, Zhang L, Zheng X, Yao Y, Wang X, Huang H, Zhang F, Su J, Zheng X, Huang X.   +11 more
europepmc   +1 more source

高糖诱导内质网应激对血管内皮细胞炎症反应的作用

Zhongshan Daxue xuebao. Yixue kexue ban, 2013
【目的】 探讨高糖通过诱导内质网应激(ERS)引起人脐静脉内皮细胞(EAhy926)炎症反应的作用机制?【方法】人脐静脉内皮细胞给予正常浓度糖(5.5 mmol/L)或高浓度糖(25 mmol/L)干预0?2?4?8?12 h,或ERS诱导剂毒胡萝卜素(TG)0.5 μmol/L干预24 h?Western blot检测下列蛋白表达水平:细胞间黏附因子-1(ICAM-1)?肿瘤坏死因子-α(TNFα)等炎症因子;葡萄糖调节蛋白78(GRP78)?磷酸化真核细胞翻译起始因子2α(p-eIF2α ...
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Role and mechanism of endoplasmic reticulum stress and NLRP3 inflammasome in acute kidney injury. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Pei M, Deng K, Chen Y.
europepmc   +1 more source

Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens. [PDF]

J Zhejiang Univ Sci B
Lu H, Guo T, Zhang Y, Liu D, Hou L, Ma C, Xing M.   +6 more
europepmc   +1 more source

[Huangpu Tongqiao Capsule improves cognitive impairment in rats with Wilson disease by inhibiting endoplasmic reticulum stress-mediated apoptosis pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhang X, Wang X, Wang J, Shao N, Cai B, Xie D.   +5 more
europepmc   +1 more source

颈交感神经干离断可通过抑制内质网应激降低大鼠脑缺血再灌注损伤

Zhongguo shiyan zhenduanxue
目的观察星状神经节阻滞（SGB）对大鼠脑缺血再灌注（I/R）损伤的影响及内质网应激（ERS）在其中发挥的作用。方法采用右侧颈交感神经干离断术（TCST）模拟星状神经节阻滞，将雄性SD大鼠分为5组：①假手术组（Sham）；②脑缺血再灌注组（I/R）；③TCST预处理+I/R组（I/R+TCST）④TCST预处理+ERS激动剂衣霉素（TM）+I/R组（I/R+TCST+TM）；⑤ERS抑制剂4-苯基丁酸（4PBA）预处理+I/R组（I/R+4PBA）。术后24 h评估以下指标：①神经功能缺损评分 ...
张云飞, 辛楠, 田海涛
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