Results 61 to 70 of about 5,871 (145)
Role of selenoprotein M knockdown in the melatonin antagonism of nickel-induced apoptosis and endoplasmic reticulum stress in mouse heart. [PDF]
J Zhejiang Univ Sci B, 2023 Zhang X +8 more
europepmc +1 more source
Research advances Progress in mechanistic studies of renal fibrosis based upon regulatory cell death [PDF]
As a basic pathological feature at advanced stage of various kidney diseases, renal fibrosis (RF) is an important cause of kidney failure. It is characterized by an excessive accumulation of extracellular matrix (ECM), damage of renal tissue structure ...
Guang-ming Yin +5 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2014 目的探讨内质网应激在糖尿病心肌病的作用及人参果皂苷的干预作用及其机制。方法将50只Wistar大鼠随机分为正常对照组（C组）10只;另40只予高脂高糖饲养4周后腹腔注射链脲佐菌素（STZ）40mg/kg×4周,成功制备糖尿病大鼠模型25只,再随机分为糖尿病模型组（D组,n=10）及人参皂苷给药组（G组,n=15,40mg/kg/d给药12周）,处死大鼠,取血测定空腹血糖、总胆固醇（TC）、甘油三酯（TG）、和心肌酶水平。留取心脏组织观察心脏形态改变,Tunel法检测心肌细胞凋亡 ...
赵良辰, 真娟, 尉海涛
doaj
[A Review of the Roles of Endoplasmic Reticulum Stress in Cancer Cell Metastasis]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2021 Zhou JF, Zhou Q, Chen C, Pan JX.
europepmc +1 more source
Linchuang shenzangbing zazhi, 2017 急性肾损伤（acute kidney injury,AKI）是一种造成多器官损伤的临床危重症,尽管AKI相关的基础研究及临床治疗在不断进步,但仍然无法解决AKI住院患者住院时间长、耗费医疗资源多、生存质量和预后差、加重家庭和社会经济负担等诸多问题[1-2]。目前研究发现,肾小管上皮细胞凋亡坏死、氧化应激、炎症、内质网（endoplasmic reticulum,ER）的功能紊乱等在AKI发病机制中起重要作用。
刘杰, 朱凯, 杨定平
doaj
Zhongguo shiyan zhenduanxue, 2017 葡萄膜炎如视网膜血管炎、白塞病等引起的黄斑水肿,在临床上非常难治。目前常用的治疗有口服或局部注射糖皮质激素,口服免疫抑制剂等。部分患者效果欠佳,往往出现黄斑水肿不能完全消退。近年来,随着抗新生血管药物在眼科的应用 ...
杨丽, 刘莉, 柳小丽
doaj
[Jiangtang Sanhuang tablet inhibits endoplasmic reticulum stress and autophagy in diabetic mouse islet cells]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2022 Zhang W, Hu Z.
europepmc +1 more source
The Mechanism underlying the Brain-specific Membrane-anchored Protein TMEM59L-Mediated Apoptosis [PDF]
, 2011 细胞凋亡（Apoptosis）是指细胞在受到内、外信号刺激后出现的一种自发的死亡过程，是一种主动的、高度有序的、由基因控制以及一系列酶参与的过程。目前发现的细胞凋亡途径主要有死亡受体途径、Caspase依赖的线粒体途径、内质网应激途径，以及Caspase非依赖的线粒体途径。其中Caspase依赖的线粒体途径，又称内源性途径，为经典凋亡途径之一。细胞凋亡不仅在个体的正常发育中起着重要作用，而且与癌症、免疫系统疾病、神经系统病变等疾病的发生密切相关。 TMEM59L为新发现的脑特异性高表达蛋白 ...
钱凌芝
core
Research progress in the role of β-arrestin 1 in the regulation of inflammatory response [PDF]
The inflammatory response is a systemic process produced by the body in response to stimulation such as infection or injury. The inflammatory response is closely related to the pathogenesis of various diseases, and plays an important role in the ...
FAN Yixuan +4 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2019 外泌体最早由Johnstone等在研究网织红细胞成熟过程中囊泡的形成时发现,是一种由各种活细胞通过内体途径产生并分泌的直径在40-100nm级的小囊泡,由脂质双分子层包裹[1]。在外泌体被发现的最初十几年中,它的生物学作用一直没有引起人们足够的重视,直到1996年,有科学家发现B淋巴细胞能够分泌具有抗原提呈作用的外泌体,这种外泌体携带有MHC-II类分子、共刺激分子和黏附分子,能够直接刺激效应CD4+T细胞进而产生抗肿瘤效应[2]。随后 ...
张传霞, 崔雅楠, 金浩范
doaj