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[Helicid alleviates depression-like behavior in rats with chronic unpredictable mild stress through the NCALD/sGC/cGMP/PKG axis]. [PDF]

open access: yesNan Fang Yi Ke Da Xue Xue Bao
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人源性的小细胞肺癌异种移植动物模型及耐药模型的建立

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2019
背景与目的 小细胞肺癌(small cell lung cancer, SCLC)是细胞分化程度低,恶性程度高,生长速度快,早期容易发生转移的恶性肿瘤。目前SCLC患者的临床治疗以化疗为主,但是在治疗6个月-9个月后极易发生获得性耐药而复发。因此,构建有效的临床前SCLC动物模型具有重要的临床价值。人源性肿瘤异种移植动物模型(patient-derived xenotransplantation, PDX)能够较好地保留原发肿瘤的特性,是比较理想的临床前动物模型。本研究旨在构建中国人来源的SCLC ...
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