Results 41 to 50 of about 16,652 (173)
The effect of regulating AQP-1 on hydrocephalus in rats [PDF]
, 2016 脑积水是神经外科的常见病，对于脑积水的治疗，目前主要以手术分流为主，常常因为引流管堵塞导致整个手术的失败。近年来的研究表明，脑积水时，AQP-1的表达是增高的，且脑积水越严重，AQP-1的表达也会越高。 目的：本实验通过药物调控AQP-1的表达，研究调控AQP-1对大鼠脑积水的治疗作用 方法：建立60只SD大鼠的脑积水动物模型，并随机的分成4组，每组15只。在建立脑积水动物模型时以及以后，分别对阳性干预组和阴性干预组腹腔注射cAMP和JNK抑制剂-SP600125；对假手术组大鼠腹腔注射等量生理盐水 ...
于宁
core
Perceived costs as drivers of wildlife management preferences in rural Tanzanian communities
Conservation Biology, EarlyView.Abstract Effectively managing human–wildlife interactions is crucial for fostering coexistence on shared landscapes. Management options are most effective when aligned with the preferences of people directly affected by wildlife, yet little is known about how socioecological factors influence these preferences.
Christian Kiffner +10 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2018 心肌纤维化动物模型在心血管疾病基础实验中占有重要地位,目前较常见的实验动物心肌纤维化造模方法有:自发性高血压大鼠心肌纤维化、糖尿病大鼠心肌纤维化、二肾一夹及肾下主动脉缩窄模型、腹主动脉缩窄法等,其中主动脉缩窄法是近几年较为主流的心肌纤维化及心衰造模方法 ...
徐为民, 孙志, 陈欢, 时景伟
doaj
The Crosstalk and Regulation of Nur77 、RXRα and Cancer [PDF]
, 2012 核受体是真核细胞生物体内一类重要的蛋白质，在机体正常生命活动过程中发挥着极其重要的作用；然而，核受体表达和功能的异常会导致严重的人类疾病。这里，我们主要研究了两种核受体Nur77和RXRα在肿瘤发生中的作用及其机制。 在第一章中，我们主要研究了孤儿核受体Nur77在结肠癌发生中的作用及其调控。孤儿核受体Nur77属于核受体超家族的重要一员，易被诱导表达。研究表明，Nur77在多种人类肿瘤中高表达，提示它与肿瘤发生紧密相关；然而，其潜在的调控机制及生物学功能尚不清楚。在本章中 ...
吴华
core
Drivers of bat researchers’ intent to adopt field hygiene practices
Conservation Biology, EarlyView.Abstract Infectious disease is a growing threat to wildlife, with zoonotic transmission most likely at the human–wildlife interface. One underappreciated activity at this interface is fieldwork with wild animals, but associated risks can be mitigated through field hygiene (FH) practices, such as using personal protective equipment and other appropriate
Joanna L. Coleman +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2012 目的建立稳定可靠的扩张型心肌病（DCM）动物模型,以供基础实验研究。方法选用雄性SD大鼠,分为正常对照组和DCM模型组,DCM组予腹腔注射阿霉素2.5mg/（kg.week）,生理盐水稀释浓度为1mg/ml,正常组腹腔注射等量生理盐水。每周根据体重调整阿霉素剂量,用药6周后,检查心脏超声、血浆脑钠肽（BNP）水平、观察心肌病理切片。结果心脏超声心动图示模型组左室射血分数（LVEF）、左室短轴缩短率（FS）,各项指标明显低于正常对照组 ...
秦保锋, 严世芸
doaj
The Expression of PolySia/TriSia Associated Proteins and Genes on Developing Brain and the Effect of Dietary Sialic Acid Intervention in Piglets [PDF]
, 2015 摘要 研究背景：唾液酸（Sialicacid,Sia）是一类九碳单糖神经氨酸的总称，在细胞表面发挥其多种生物学功能。在体内，Sia通常以游离唾液酸、聚唾液酸（多聚/寡聚）、唾液酸衍生物（糖蛋白，糖脂）这三种形式存在。多聚唾液酸（polySialicacid,ploySia），一种唾液酸残基通过α2-8键连接而成的线性聚合物，广泛分布于在哺乳动物神经系统中，它的主要蛋白载体是神经细胞粘附因子（Neuralcelladhesionmolecule,NCAM）。PolySia-NCAM在细胞迁移、神经突生长 ...
任贺
core
Structured machine learning modeling to support conservation of deep‐sea benthic biodiversity
Conservation Biology, EarlyView.Abstract Biodiversity monitoring programs need to deliver accurate, timely, and actionable predictions. To establish a predictive monitoring program for deep‐sea benthos of the Santos Basin, Brazil, we developed a two‐stage structured model that allowed comparison of biodiversity predictions obtained from environmental simulations (2M‐Sim).
Gustavo Fonseca +23 more
wiley +1 more source
Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer [PDF]
, 2010 Background and objective Radiation sensitivity is closely related to tissue oxygen, and rh-endostatin can induce the high level of oxygen content in tumor by "normalizing" tumor angiogenesis which is associated with radiotherapy sensitivity.
Changhu LI +5 more
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Regulatory compliance and support for altered management of the exotic pet trade
Conservation Biology, EarlyView.Abstract Globally, the exotic pet trade has contributed to species invasion, disease, and animal welfare risks. Although scientists have advocated for increased trade regulation, the success of management and regulatory efforts depends on compliance by participants in the exotic pet trade. We used a regulatory compliance framework to investigate exotic
Elizabeth N. Pratt +3 more
wiley +1 more source