Results 71 to 80 of about 16,652 (173)

The impact and the functional mechanism of autologous platelet-rich plasma on free flap graft survival: A preliminary study in rabbits [PDF]

open access: yes, 2016
摘要 研究目的:探讨局部应用PRP对游离皮瓣存活的影响,深入了解自身来源的富血小板血浆(PRP)在皮瓣转移过程中的作用,并初步探讨PRP影响游离皮瓣生长的作用机制,为PRP的实验研究和临床应用提供理论依据。 研究方法:将30只新西兰大白兔编号,用随机数表法随机分为实验组和对照组,每组15只新西兰大白兔。取兔子自身动脉血制备PRP,检测PRP中血小板和生长因子浓度,并计算其浓缩倍数。实验组处理:游离皮瓣基底部涂抹1.0ml的PRP,然后将游离皮瓣原位缝合;对照组处理:游离皮瓣基底部涂抹1.0ml的生理盐水,
王彪
core  

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

open access: yesVeterinary Dermatology, Volume 37, Issue 3, Page 353-364, June 2026.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon   +5 more
wiley   +1 more source

TIPE2 promote synovial fibroblasts cell apoptosis of adjuvant arthritis rats by up-regulating caspase while down-regulating NF-κB [PDF]

open access: yes, 2015
目的:TIPE2能够抑制炎症以及肿瘤的发生发展,并且TIPE2过表达能够促进细胞的凋亡。类风湿关节炎是一种免疫多态性慢性疾病,我们应用类风湿关节炎模型大鼠佐剂型关节炎滑膜成纤维样细胞(fibroblast-likesynoviocytesofratadjuvantarthritis,AA-FLS),通过体外实验分析TIPE2对死亡受体5诱导细胞凋亡的作用探讨TIPE2对佐剂型关节炎发病的影响。 方法:通过RT-PCR、荧光实时定量PCR和Western ...
石春燕
core  

An Ultrasound‐Triggered Antibacterial Hydrogel With Integrated Antioxidant and Angiogenic Functions for Infected Wound Care

open access: yesRare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Managing diabetic wounds requires simultaneously addressing their infectious, oxidative, and regenerative impairments. To address this, this study integrates a piezoelectric BiOCl@CuSe heterojunction (PFM‐verified) into an injectable F127/HA hydrogel, creating an ultrasound‐responsive smart dressing.
Jiayan Guo   +5 more
wiley   +1 more source

阿霉素诱导大鼠扩张型心肌病模型的建立

open access: yesZhongguo shiyan zhenduanxue, 2010
目的建立稳定可靠的扩张型心肌病(dilated cardiomyopathy,DCM)动物模型,以供基础实验研究。方法选用雄性Wistar大鼠,分为正常对照组和DCM模型组,DCM组接受腹腔注射生理盐水溶解的阿霉素2.5 mg/(kg.week),稀释浓度1 mg/ml;正常组腹腔注射等量生理盐水。每周根据体重调整阿霉素剂量,用药6周后,停药观察2周。记录大鼠体重的变化及死亡率,检查超声心动图检查、血浆脑利钠肽(BNP)水平、测量左心室内径、观察心肌病理切片、电镜、Masson染色结果 ...
周岩, 赵丽蓉, 杨思睿
doaj  

Complete androgen insensitivity syndrome, a pedigree gene mutation analysis [PDF]

open access: yes, 2016
研究背景 雄激素不敏感综合征(AndrogenInsensitivitySyndrome,AIS),是一种常见的男性假两性畸形。是伴X连锁隐性遗传病。患者染色体核型为46,XY,但其X染色体上的雄激素受体(Androgenreceptor,AR)基因存在缺陷,可致雄激素靶器官上的AR出现缺陷,体内的雄激素不能发挥相应的作用而出现相应的临床症状。此疾病可对患者的生殖能力造成不同程度的影响,还可能引发与性发育异常相关的性心理、性行为的异常,并可能给社会和患者家庭造成难以挽回的损失 ...
杨瑞娟
core  

Constructing Asymmetric Cu–OV–Mn Sites on MOFs‐Derived Cu‐MnOx Microspheres With Abundant Oxygen Vacancies for Enhanced Photothermal VOC Degradation

open access: yesRare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT With the growing severity of volatile organic compounds (VOCs) pollution, metal‐organic frameworks (MOFs)‐derived materials offer a promising solution through efficient photothermal catalysis. In this paper, M‐MnOx (M = Cu, Ni, Co, Fe) catalysts derived from manganese‐based MOFs were successfully prepared by the sacrificial template method and
Yizhong Liao   +10 more
wiley   +1 more source

新型动脉瘤动物模型的建立及彩色多普勒评价

open access: yesZhongguo shiyan zhenduanxue, 2010
目的建立形态、病理、行为表现及血流动力学特点都更加逼真的动脉瘤动物模型,并应用彩色多普勒对动脉瘤模型进行评价。方法采用新西兰大白兔16只,应用显微缝合法制作侧方动脉瘤模型8只,顶端动脉瘤模型8只。分别于动脉瘤建立后即刻和2周测量动脉瘤的直径,并于2周后行彩色多普勒测定载瘤动脉及动脉瘤内血流速度。结果共制作侧方动脉瘤模型8个,顶端动脉瘤模型8个,其中顶端动脉瘤模型有1枚动脉瘤模型建立术后24小时破裂,1枚动脉瘤术后2周破裂。2周后行彩色多普勒检查发现载瘤动脉血流速度较动脉瘤内血流速度快 ...
李淼   +8 more
doaj  

The Research on the promoter of wsv249 and subcellular localization of WSV249 and WSV403 [PDF]

open access: yes, 2016
对虾是一种广温广盐性的海产虾类,近年来我国对虾养殖的年产量超过百万吨。对虾养殖产业中细菌性和病毒性疾病严重制约对虾产业的发展。白斑综合症病毒(Whitespotsydromevirus,WSSV)是养殖对虾爆发性传染疾病的主要病害之一。因此对虾疾病尤其是WSSV的侵染机制成为目前研究的热点,病毒极早期基因在病毒感染宿主的过程中起着关键作用,对其进行研究有助于进一步揭示WSSV的侵染机制,为WSSV的防治提供新思路。本研究工作的内容主要包括以下几部分: (1)构建一系列wsv249的启动子249P ...
徐晓敏
core  

Internal physiological drivers of leaf development in trees: Understanding the relationship between non‐structural carbohydrates and leaf phenology

open access: yesFunctional Ecology, Volume 40, Issue 5, Page 1151-1164, May 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Plant phenology is crucial for understanding plant growth and climate feedback. It affects canopy structure, surface albedo, and carbon and water fluxes. While the influence of environmental factors on phenology is well‐documented, the role of plant intrinsic factors ...
Yunpeng Luo   +8 more
wiley   +1 more source

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