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Journal of Diabetes, Volume 13, Issue 8, Page 640-647, August 2021., 2021 Highlights A nested, nationwide, propensity‐matched cohort study was carried out using the Clinical Practice Research Datalink with 1186 patients with no past history of ASCVD, half of whom had undergone bariatric surgery. Bariatric surgery was associated with improved ASCVD outcomes and lower mortality, highlighting a potential prognostic role of the ...
Maddalena Ardissino +6 more
wiley +1 more source
TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells [PDF]
, 2016 溶血卵磷脂（lysophosphatidylcholine，lysoPC）是氧化低密度脂蛋白（oxidizedlow-densitylipoprotein，ox-LDL）的主要成分。早期的研究表明，lysoPC可诱导人冠状动脉平滑肌细胞（humancoronaryarterysmoothmusclecells，HCASMCs)凋亡，但具体机制尚不清楚。近期，我们通过细胞活力测定，流式细胞术，共聚焦显微镜及分子生物学手段对lysoPC作用的分子机制进行研究发现，lysoPC可引发细胞外钙离子内流 ...
王渊
core +1 more source
Research progress on the role and mechanism of ADAMTS9 in atherosclerosis [PDF]
, 2023 Atherosclerosis is an inflammatory disease of arterial stenosis caused by the imbalance of lipid metabolism and atherosclerotic plaques clustered on the arterial wall.
Zeng Shiting, Huang Zhiyong, Chen Linfa, Yuan Yanquan, Li Qingyu
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, 2017 动脉粥样硬化是一种较为严重的心脑血管疾病,对人体健康有着十分严重的危害。在临床上,通心络胶囊是一种常用的药物,能够有效的保护心脏、血管、血液,对于脑梗死、心肌梗死、冠心病、动脉粥样硬化等疾病的治疗中,均可发挥出良好的效果。在实际治疗中,药物可通过稳定斑块、调节血脂、改善心功能、缓解急性冠状动脉综合征等作用 ...
方鉴
core +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015 Phlegm is one of the most common patterns of coronary artery disease (CAD) in Chinese medicine. Our research was aimed at investigating the association between phlegm syndrome of CAD and coronary angiography (CAG) by meta‐analysis. According to inclusion criteria, a total of 30 studies involving 5,055 CAD patients were included.
Qiu-Yan Zhang +6 more
wiley +1 more source
Correlation analysis between sleep quality and carotid atherosclerosis in low and moderate risk individuals for cardiovascular and cerebrovascular diseases [PDF]
, 2023 Objective·To explore the relationship between sleep quality and carotid atherosclerosis in the population with low or moderate risk of cardiovascular and cerebrovascular diseases.Methods·Based on the population-based cohort study of chronic
HAMULATI Xieyire +5 more
core +1 more source
血浆同型半胱胺酸和D-二聚体水平与急性期脑梗死各亚型的关系 [PDF]
, 2014 目的：探讨血浆同型半胱胺酸和D-二聚体在急性期各亚型脑梗死之间的差异，为临床脑梗死亚型的病因学诊断提供理论依据。方法：收集我院246例24 h内发病的脑梗死患者，根据TOAST分型方法进行病因学分型：大动脉粥样硬化性脑卒中(1arge—artery atherosclerosis，LAA；n=66)、小动脉闭塞性脑卒中(small-artery occlusion ,SAO；n=76)、心源性脑栓塞(cardio embolism，CE；n=40)、其他确定原因引发的缺血性脑卒中(stroke of ...
Da-lin YU +6 more
core +3 more sources
The effects of miR-30c-1-3p regulating group ⅡA secretory phospholipase A2（sPLA2-ⅡA）expression on the pathogenic mechanism of atherosclerosis [PDF]
, 2015 动脉粥样硬化（Atherosclerosis，AS）是急性冠脉综合症、脑卒中等众多心脑血管疾病共同的病理基础。sPLA2-ⅡA在动脉粥样硬化病变处含量明显增多、活性显著增强，同时伴随中性粒细胞的增多。sPLA2-ⅡA以酶的催化水解作用和作为致炎因子的促炎症反应双重生物学作用参与AS发生发展的各个阶段。 MicroRNA（miRNA）是近年发现广泛存在于真核细胞中的高度保守的、非编码单链小分子RNA，具有最广泛的基因调节功能，参与机体多种生理、病理过程的调控。 我们运用miRNA靶基因预测软件发现miR ...
夏小春
core
The Role of Steroid Receptor Coactivator 3 in Atherosclerosis [PDF]
, 2016 目的：动脉粥样硬化是动脉壁对炎症的损伤性反应，是多种细胞及因子相互作用的结果，但目前的发病机制仍不清楚。血管内皮损伤、脂质代谢紊乱、炎症反应在其发生发展中都扮演重要角色。类固醇受体辅激活因子3不仅能抑制甘油三酯向肝外转运，而且在炎症应答中扮演着重要角色，目前SRC-3在动脉粥样硬化中的研究还未曾报道，我们的研究旨在揭开SRC-3对动脉粥样硬化的影响的具体机制。方法：确定动脉粥样斑块的血管SRC-3表达量增高后，我们获取APOE-/-、SRC-3-/-敲除小鼠和APOE-/-、SRC-3+/+小鼠 ...
苏强
core
CT imaging anatomy of myocardial bridge-mural coronary artery and its relationship with atherosclerosis [PDF]
, 2015 研究背景:心肌桥-壁冠状动脉（MB-MCA）是一种先天性冠状动脉解剖变异，一直被认为是种良性病变。一般情况下，不引起临床症状，但可能出现心肌缺血、心律失常、心肌梗死及猝死等临床表现。明确MB-MCA的形态学特征及其与冠状动脉粥样硬化之间的关系，为相关疾病的诊断及治疗提供解剖依据。 目的：（1）应用64排多层螺旋CTA观察并测量MB-MCA发生率及其形态学特征；（2）探讨左前降支心肌桥（LAD-MB）与冠状动脉粥样硬化的关系。 实验方法：（1）回顾性分析本院2013.05-2014 ...
李菊香
core