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Study on Secondary Metabolites Produced by Three Strains of Endophytic Fungi Isolated from Pharmaceutical Plants [PDF]

, 2009
本论文从共生理论出发，在对采集自福建龙岩山区的药用植物南方红豆杉的内生真菌进行分离，并对其抗菌、抗肿瘤以及抗氧化等生物活性筛选的基础上，选取3株经分子生物学鉴定的药用植物内生真菌Xylarialessp.Hds65,Cordycrpssinensis（Berk.）Sacc.A18和Fusariumsp.MH05进行代谢产物的初步研究。旨在发现具有较强生物活性的新化合物，为开发新型抗菌抗肿瘤药物提供研究基础。 从南方红豆杉的树叶、短茎和树皮中共分离得到107株内生真菌。抗菌、抗氧化和抗肿瘤活性检测结果显示，
于淼
core  

丹参多酚酸盐对匹鲁卡品致痫大鼠BDNF表达的影响

Zhongguo shiyan zhenduanxue, 2011
目的探讨丹参多酚酸盐对匹鲁卡品致痫大鼠脑内神经元的损伤及BDNF表达的影响,探讨其抗痫的可能机制。方法采用匹鲁卡品诱发癫痫状态模型,随机分为丹参多酚酸盐干预组、盐水干预组和对照组,观察各组大鼠的行为学改变,用免疫组织化学法标记显示各组大鼠脑内海马BDNF的表达变化。结果在海马CA1区有BDNF阳性细胞表达,各组比较行t检验,差异有统计学意义 ...
陈丽丽, 黄靓妹, 詹红艳, 曹亦宾, 史楠, 黎洁, 王丹丹   +6 more
doaj  

神经肽Y、丹参多酚酸盐对癫痫大鼠海马FOS蛋白表达的影响及作用探讨

Zhongguo shiyan zhenduanxue, 2011
目的探讨NPY及丹参多酚酸盐干预对大鼠海马FOS蛋白的表达影响研究及作用探讨。方法采用匹鲁卡品诱发癫痫状态模型,随机分为丹参多酚酸盐干预组、NPY干预组、盐水干预组和对照组,观察各组大鼠的行为学改变,用免疫组织化学法标记显示各组癫痫发作脑内海马FOS蛋白的表达变化。结果在海马门区、CA3区、CA1区有FOS阳性细胞表达,干预方法不同,海马FOS阳性细胞数表达不同,NS、NPY、丹参多酚酸盐干预组FOS阳性细胞数高于对照组,差异有统计学意义 ...
陈丽丽, 黄靓妹, 詹红艳, 曹亦宾, 张宏   +4 more
doaj  

丹参多酚酸盐及神经肽Y干预后癫痫大鼠海马神经肽Y的表达变化

Zhongguo shiyan zhenduanxue, 2011
目的探讨丹参多酚酸盐及神经肽Y（neuropeptide-Y,NPY）干预注射对海马NPY的表达影响研究。方法采用匹鲁卡品（PILO）诱发癫痫模型,随机分为NPY干预组、丹参多酚酸盐干预组、盐水干预组和对照组,观察各组大鼠的行为学改变,用免疫组织化学法标记显示各组大鼠脑内海马NPY的表达变化。结果在海马门区、CA3区、CA1区有NPY阳性细胞表达,生理盐水及丹参多酚酸盐干预组可见颗粒细胞中NPY的异位表达。干预方法不同,海马NPY阳性细胞数表达不同,生理盐水（NS ...
陈丽丽, 黄靓妹, 詹红艳, 曹亦宾, 张宏   +4 more
doaj  

[Determination of 18 caine anesthetics in animal meat using solid phase extraction combined with ultra-performance liquid chromatography-tandem mass spectrometry]. [PDF]

Se Pu, 2023
Wu SM, Ouyang LQ, Meng P, He MH, Lin Q, Chen YK, Liu WJ, Su XM, Dai M.   +8 more
europepmc   +1 more source

[Liquid chromatography-high resolution mass spectrometry analysis of 300 illegally added drugs and their analogues in functional milk powder for the elderly]. [PDF]

Se Pu, 2023
Ning X, Jin SM, Li ZY, Yang CJ, Mao D, Cao J.   +5 more
europepmc   +1 more source

[Dispersive solid-phase extraction combined with high-performance liquid chromatography for determination of seven anesthetics in aquatic products]. [PDF]

Se Pu, 2022
Shi F, Shou D, Jin M, Wang H, Chen X, Zhu Y.   +5 more
europepmc   +1 more source

[Expert consensus on the management of B-cell lymphoma-related cardiovascular diseases with Bruton tyrosine kinase inhibitors (2023)]. [PDF]

Zhonghua Xue Ye Xue Za Zhi, 2023
Hematological Oncology Committee of China Anti-Cancer Association, Chinese Society of Hematology, Chinese Medical Association, Chinese Workshop on Chronic Lymphocytic Leukemia.   +3 more
europepmc   +1 more source

[Fast screening and confirmation of 73 common prohibited compounds in cosmetics by ultra performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry]. [PDF]

Se Pu, 2022
Li Y, Huang J, Fang J, Huang Z.
europepmc   +1 more source

Guidance on the management of adverse reactions induced by poly(ADP-ribose) polymerase inhibitors. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban, 2022
Society of Obstetrics and Gynecology of Zhejiang Medical Association, Society of Urology of Zhejiang Medical Association, Committee of Breast Cancer of Zhejiang Anticancer Association, Committee of Clinical Pharmacy on Oncology of Zhejiang Anticancer Association (preparation), Committee of Urology of Zhejiang Society for Mathematical Medicine.   +4 more
europepmc   +1 more source