, 2015 为全面了解己烯雌酚在鲫鱼体内的残留、消除和药物动力学特征,采用超高效液相色谱-串联质谱法,研究口服灌药给药时己烯雌酚及其主要代谢物双烯雌酚在鲫鱼体内的组织分布和药物代谢动力学。在水温(12±2)℃条件下,鲫鱼口服灌药0.1,1.0 mg/(kg bw)和10.0 mg/(kg bw)后,其血浆、肌肉和肝脏中己烯雌酚浓度-时间曲线关系符合一级吸收的二室开放动力学模型。以剂量1.0 mg/(kg bw)为例,3种组织中己烯雌酚峰值水平肝脏最高,肌肉次之,血浆最低,己烯雌酚的平均消除速率均较快,分别为26 ...
田秀慧 +5 more
core
[How I treat pediatric febrile infection-related epilepsy syndrome]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiDeng XL, Peng J.
europepmc +1 more source
[Determination of the key characteristic components in ginger from different origins by internal extractive electrospray ionization mass spectrometry]. [PDF]
Se PuWang HT +5 more
europepmc +1 more source
Dianci bileiqi复合绝缘子已在我国交直流输电工程中得到广泛应用，然而运行过程中冷热冲击、极端温度、机械应力都会加速其绝缘老化，并且芯棒部分易出现微小缺陷成为绝缘薄弱环节。交联度是影响环氧树脂内部交联结构的重要因素之一，研究交联结构与环氧树脂热力学性能之间的关系，对于提升其绝缘可靠性具有重要意义。因此本研究基于分子动力学的方法，构建了不同交联度的双酚A环氧树脂模型，从微观角度分析了交联度对环氧树脂热学力学性能的影响。结果表明，随着交联度的不断提高，其热学力学性能提升较为明显。从分子角度来讲 ...
刘会斌 +6 more
doaj
[Expectant management versus acetaminophen for early treatment of hemodynamically significant patent ductus arteriosus in very preterm infants: a randomized controlled trial]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiXu SY +8 more
europepmc +1 more source
[Ethyl caffeate alleviates dextran sulfate sodium-induced colitis in mice by restoring intestinal epithelial tight junctions <i>via</i> activating the Wnt/β-Catenin pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhang K +7 more
europepmc +1 more source
[Interpretation of the American Dental Association practice guidelines for the management of acute dental pain with pharmacotherapy (2023-2024) and its clinical implications for China]. [PDF]
Hua Xi Kou Qiang Yi Xue Za ZhiZhao D, Zheng L.
europepmc +1 more source
[The role of hepatocyte programmed cell death in liver fibrosis]. [PDF]
Zhonghua Gan Zang Bing Za ZhiZhou M, Zeng ZJ, Yang XK, Li H.
europepmc +1 more source
[Recent advances of affinity ultrafiltration-liquid chromatography-mass spectrometry in screening natural active substances]. [PDF]
Se PuXu YB, Niu YJ, Guo MQ.
europepmc +1 more source
[Rapid response to linperlisib in relapsed/refractory autoimmune hemolytic anemia: a case report]. [PDF]
Zhonghua Xue Ye Xue Za ZhiLiu ZW, Chen M.
europepmc +1 more source