右美托咪定复合舒芬太尼镇痛对老年髋关节置换术后患者镇痛效果、应激反应及炎症因子的影响
Zhongguo shiyan zhenduanxue, 2017 目的探讨右美托咪定复合舒芬太尼对老年髋关节置换术后镇痛效果、应激反应及炎症因子的影响。方法选取2014年6月至2016年6月行单侧髋关节置换治疗的老年患者,随机分为两组,每组各45例。对照组术后给予舒芬太尼镇痛,观察组给予右美托咪定复合舒芬太尼镇痛。比较两组患者术后6h（T1）、术后12h（T2）、术后24h（T3）、术后48h（T4）镇痛效果、应激激素和炎症因子的差异。结果观察组48h内PCIA按压次数（14.6±6.2）次,对照组按压（36.7±9.2）次,两组间差异具有统计学意义（t=13.363,
庞海涛
doaj
盐酸右美托咪定对颅内动脉瘤夹闭术患者血流动力学及脑氧代谢的影响
Zhongguo shiyan zhenduanxue, 2013 目的评价盐酸右美托咪定对颅内动脉瘤夹闭术患者血流动力学及脑氧代谢的影响。方法全麻下行颅内动脉瘤夹闭术患者60例,ASA分级Ⅰ或Ⅱ级。采用随机数字表法,将其随机分为2组.每组30例。Ⅰ组病人单次输注右美托咪定1μg/kg,输注时间10min,然后改为维持输注0.5μg/kg.hr,Ⅱ组病人输注等量生理盐水。单次输注结束后依次静脉注射咪达唑仑2mg、异丙酚2mg/kg、舒芬太尼0.5μg/kg、维库溴铵0.1mg/kg诱导,插入气管导管,控制呼吸。全静脉维持麻醉维持深度,使脑电双频谱指数（BIS）维持在40-
柏晓漫, 梁枫, 李龙云, 陈鹏
doaj
[Application of dexmedetomidine in children with agitation during ventilator weaning]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2019 He J +6 more
europepmc +1 more source
右美托咪定复合罗哌卡因骶管阻滞应用于小儿先天性髋关节脱位手术的影响
Zhongguo shiyan zhenduanxue, 2017 先天性髋关节脱位是小儿较为常见的先天畸形,常常需要髋臼成形、股骨截骨等手术治疗。手术时间长,刺激强度大,术后患侧肢体石膏固定活动受限,造成小儿术后躁动及疼痛剧烈。骶管阻滞麻醉因其镇痛效果好,副作用少及操作简单的特点被广泛应用于小儿下腹部及下肢手术的镇痛。单纯罗哌卡因骶管阻滞持续镇痛时间仅为4-6h,国外文献报道[1],右美托咪定作为佐剂应用于成人神经阻滞可有效延长罗哌卡因镇痛时间,麻醉方法安全可靠 ...
刘双梅, 仲宇, 吴秀英
doaj
[Dexmedetomidine alleviates cognitive dysfunction induced by tibial fracture in rats]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2019 Zhang J, Zhang X, Qian H, Cui J, Gu X.
europepmc +1 more source
[Postoperative Delirium in Patients on Cardiopulmonary Bypass for Cardiovascular Surgeries: Incidence and Influencing Factors]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 Zhou C +9 more
europepmc +1 more source
[Analgesic effect of dexmedetomidine on oxaliplatin-induced neuropathic pain in rats]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2018 Li S, Ouyang B, Zhao X, Wang Y.
europepmc +1 more source
[Protective effects of dexmedetomidine against pulmonary ischemia-reperfusion injury during cardiopulmonary bypass in rats]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2019 Cao G, Zhang E.
europepmc +1 more source
[Dexmedetomidine attenuates heat stress-induced oncosis in human skeletal muscle cells by activating the Nrf2/Ho-1 pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLiu Y +5 more
europepmc +1 more source
[Dexmedetomidine inhibits ferroptosis of human renal tubular epithelial cells by activating the Nrf2/HO-1/GPX4 pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhang F, Liu G.
europepmc +1 more source