Results 91 to 100 of about 1,996 (175)
Small interfering RNA mediated multi-target therapy of cancer [PDF]
, 2009 : It has been reviewed that as many as hundreds genes are dysregulated in various kinds of cancers, yet most therapies are targeted toward a single gene.
Rong-Guang Shao
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Recent Advances and Strategies in the Development of Therapeutic Radiopharmaceuticals [PDF]
Therapeutic radiopharmaceuticals can be employed in the treatment of various tumor diseases，and their global market share is likely to witness an explosive growth in the recent decade.
Hao CHEN +8 more
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[Using Immunohistochemical Markers and Clinicopathological Factors to Predict the Prognostic Survival of Different Types of Endometrial Cancer Recurrence]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2021 Huang Z +6 more
europepmc +1 more source
The Effect and Mechanism of Metformin on the Cholangiocarcinoma Cell Lines Mz-ChA-1 and QBC939 [PDF]
, 2017 胆管癌是起源于胆管不同部位的上皮细胞肿瘤的统称，是除了原发性肝癌外最常见的肝部肿瘤。手术切除是治疗胆管癌最有效的方式，但由于胆管癌临床症状隐蔽，绝大部分病人确诊时已是晚期，无法再从手术中获益。系统性的化疗与放射治疗也已被应用到胆管癌的治疗中，但这些疗法都未能显著改善病人的预后。因此，亟待开发新的胆管癌治疗策略。 二甲双胍是临床上广泛使用的抗二型糖尿病药物，最近流行病学调查和临床试验发现二甲双胍也具有抗肿瘤的潜在价值。本课题中，我们观察到二甲双胍对人胆管癌细胞Mz-ChA ...
张金
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Exploring the Mechanism of Hippophae Fructus Anti-obesity through Network Pharmacology and Molecular Docking [PDF]
Objective: To investigate the active components, protein targets, and mechanisms underlying the anti-obesity effects of Hippophae fructus using network pharmacology and molecular docking techniques, and to validate its in vitro anti-obesity efficacy ...
Chun ZHANG +8 more
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Research progress of glycoprotein non-metastatic melanoma protein B in lung diseases [PDF]
Glycoprotein non-metastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that plays an important role in various physiological and pathological processes. In recent years, its role in lung diseases has gradually attracted attention. Studies
Huiyi SHEN +3 more
core +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2009 【目的】 探讨子宫内膜癌组织中错配修复基因hMLH1 的表达和启动子甲基化状态与子宫内膜癌发生的关系65377;【方法】 应用免疫组化链霉素抗生物素- 过氧化物酶法(S-P法)和甲基化特异性聚合酶连反应(MSP)方法,检测37例子宫内膜癌组织和20例正常增生期子宫内膜组织中hMLH1蛋白的表达和启动子甲基化状态65377;【结果】 37例子宫内膜癌组织和20例正常增生期子宫内膜组织hMLH1基因蛋白表达分别为51.4%(19/37),85%(17/20);基因启动子甲基化分别为43.2%(16/37 ...
doaj
Zhongguo shiyan zhenduanxue, 2008 目的探讨绝经后子宫出血的临床特征与病种的关系,以及宫腔镜检查在绝经后子宫出血诊断中的价值。方法使用带接触镜的CO2宫腔镜对50例绝经后子宫出血的患者进行检查,对子宫内膜弥漫性增生者,均做宫内膜和宫颈粘膜活检,并行分段诊刮术。取出组织做病理检查,术后口服抗生素3-5天。结果引起绝经后子宫出血的46%是子宫内膜炎,绝经后出血的第二大原因是子宫内膜息肉,占32%,子宫内膜癌占12%。子宫肌瘤（粘膜下）引起绝经后子宫出血所占的比例较小。使用宫腔镜对子宫内病变的诊断准确率可达100 ...
萧丽娟
doaj
雌、孕激素及促性腺激素水平测定对于绝经后妇女子宫内膜异常病变筛查的临床研究
Zhongguo shiyan zhenduanxue, 2008 目的探讨性激素水平测定对于筛查绝经后妇女子宫内膜病变的意义。方法选取我院门诊有充分手术指征的绝经后流血的患者,空腹时采肘静脉血3 ml采用放射免疫RIA法测定性激素水平,并行分段诊刮,任何程度的子宫内膜增殖或增生均视为异常子宫内膜。结果绝经后妇女子宫内膜异常病变患者的雌激素水平明显高于正常绝经妇女 ...
李明勋, 朴锦丹, 张明, 徐荣春
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