Results 81 to 90 of about 1,432 (110)
, 1995 抗氧化剂知母宁对阿霉素毒性和抗肿瘤活性的影响李忌，李明（厦门大学抗癌研究中心厦门361005深圳999企业集团医药研究院）阿霉素（dOXOrubICIn，dOX）作为多种恶性肿瘤的主要化疗药物已广泛应用于临床。但由于dOX在细胞内经氧化还原徨循环可诱 ...
李忌, 李明
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Effect of Notch-1 gene uprugulation on AKT-m TOR signal of U251 cell [PDF]
, 2016 目的:观察上调Notch-1基因对人胶质瘤U251细胞生学物行为及AKT-m TOR信号通路的影响。方法:采用p NL-NICD慢病毒感染U251细胞,以RT-PCR和Western-Blot检测Notch-1基因mRNA和蛋白的表达,以MTT检测细胞增殖能力,流式细胞术检测细胞周期变化,Transwell实验检测细胞侵袭能力,同时检测Notch-1上调对AKT、m TOR、P70S6K、4Ebp-1蛋白的影响。结果:与对照组比较,NICD慢病毒转染72h后,Notch-1基因mRNA和蛋白表达明显增高(
戴明明, 林勤, 楚可新, 赵能江
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Small interfering RNA mediated multi-target therapy of cancer [PDF]
, 2009 : It has been reviewed that as many as hundreds genes are dysregulated in various kinds of cancers, yet most therapies are targeted toward a single gene.
Rong-Guang Shao
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Zhongguo shiyan zhenduanxue, 2010 目的探讨宫腔镜诊断子宫内膜癌的临床价值。方法回顾性分析了65例子宫内膜癌患者的临床资料,以手术病理结果为金标准,将术前分段诊刮和宫腔镜检查结果分别与手术病理结果对照分析。结果（1）33例宫腔镜组患者诊断为子宫内膜癌30例,诊断符合率为90.9%;32例诊刮术组患者诊断为子宫内膜癌17例,诊断符合率为53.1%,两组比较有显著性差异 ...
尹德娥, 李玉
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Zhongguo shiyan zhenduanxue目的 探索肿瘤相关糖类抗原Tn在子宫内膜癌病人中的表达及其生物学意义。方法 首先采用免疫组化染色(IHC)技术检测人子宫内膜癌组织、子宫内膜非典型增生组织和正常子宫内膜组织的Tn抗原表达状况；然后采用CRISPR/Cas9技术特异性敲除人子宫内膜癌细胞(Ishikawa、HEC-1B)的Cosmc基因以诱导Tn抗原表达；应用流式细胞技术检测Tn抗原的表达，并采用Transwell实验检测Tn抗原异常表达对子宫内膜癌细胞迁移和侵袭能力的影响；最后采用western ...
茹晓莉, 曹广明, 刘崇东
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Zhongguo shiyan zhenduanxue, 2017 子宫内膜癌为女性常见恶性肿瘤之一,发病率仅次于宫颈癌,占生殖道恶性肿瘤20%-30%[1],其病因尚未完全明确。有研究认为子宫内膜癌与雌激素水平、内膜增生及遗传等因素相关[2]。子宫内膜癌早期诊断、早期治疗可取得良好疗效,其5年生存率可达70%[3]。溶血磷脂酸（LPA）为血小板、成纤维细胞、癌细胞等分泌的一种多功能的"磷脂信使",近年研究显示其作为肿瘤标志物有广阔的临床应用前景。本文回顾性分析2012年 ...
刘曼
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The Effect and Mechanism of Metformin on the Cholangiocarcinoma Cell Lines Mz-ChA-1 and QBC939 [PDF]
, 2017 胆管癌是起源于胆管不同部位的上皮细胞肿瘤的统称，是除了原发性肝癌外最常见的肝部肿瘤。手术切除是治疗胆管癌最有效的方式，但由于胆管癌临床症状隐蔽，绝大部分病人确诊时已是晚期，无法再从手术中获益。系统性的化疗与放射治疗也已被应用到胆管癌的治疗中，但这些疗法都未能显著改善病人的预后。因此，亟待开发新的胆管癌治疗策略。 二甲双胍是临床上广泛使用的抗二型糖尿病药物，最近流行病学调查和临床试验发现二甲双胍也具有抗肿瘤的潜在价值。本课题中，我们观察到二甲双胍对人胆管癌细胞Mz-ChA ...
张金
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Recent Advances and Strategies in the Development of Therapeutic Radiopharmaceuticals [PDF]
Therapeutic radiopharmaceuticals can be employed in the treatment of various tumor diseases，and their global market share is likely to witness an explosive growth in the recent decade.
Hao CHEN +8 more
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Exploring the Mechanism of Hippophae Fructus Anti-obesity through Network Pharmacology and Molecular Docking [PDF]
Objective: To investigate the active components, protein targets, and mechanisms underlying the anti-obesity effects of Hippophae fructus using network pharmacology and molecular docking techniques, and to validate its in vitro anti-obesity efficacy ...
Chun ZHANG +8 more
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Research progress of glycoprotein non-metastatic melanoma protein B in lung diseases [PDF]
Glycoprotein non-metastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that plays an important role in various physiological and pathological processes. In recent years, its role in lung diseases has gradually attracted attention. Studies
Huiyi SHEN +3 more
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