环状RNA circ_0120051通过miR-144-3p/IDH2轴抑制心肌成纤维细胞的纤维化表型研究
目的研究环形 RNA circ_0120051对心肌成纤维细胞的纤维化表型的调控作用和机制。方法通过实时萤光定量PCR(RT-qPCR)检测健康器官捐献者(n=24)与心力衰竭(HF)病人(n=21)心肌标本中 circ_0120051及其宿主基因溶质载体家族8成员A1(SLC8A1)的表达水平。核糖核酸外切酶(RNase R)消化实验鉴定circ_0120051的RNA稳定性。RT-qPCR检测circ_0120051在人心肌细胞AC16中的核质分布情况。利用腺病毒在C57BL/6乳小鼠心肌成纤维细胞(
梁俣 +7 more
doaj
[Silencing DDX17 inhibits proliferation and migration of pulmonary arterial smooth muscle cells <i>in vitro</i> by decreasing mTORC1 activity]. [PDF]
Deng X +6 more
europepmc +1 more source
[Association between umbilical cord blood proteome and early infant neurodevelopmental risk]. [PDF]
Mo J, Wang H, Liu J, Li Q, Su T, Ji Y.
europepmc +1 more source
狭缝引导配体1-3’非翻译区抑制心肌成纤维细胞纤维化表型的作用
目的研究狭缝引导配体1(Slit1)的3’非翻译区序列部分片段(Slit1-3’UTR)对心肌成纤维细胞的纤维化表型的调节作用和可能机制。方法利用腺病毒介导在ICR乳小鼠心肌成纤维细胞(mCFs)中过表达Slit1-3’UTR 1526nt序列(Slit1-3’UTR 1526nt),使用蛋白质免疫印迹技术评估mCFs中胶原Iα1/(COL1A1)、胶原IIIα1/(COL3A1)、α平滑肌肌动蛋白(α-SMA)等纤维化相关基因的表达水平,结合EdU和Trans ...
王娅 +7 more
doaj
[Childhood acute myeloid leukemia with <i>TLS::ERG</i> fusion gene: a clinical analysis of 12 cases]. [PDF]
Li X +10 more
europepmc +1 more source
[Expression of Notch signaling pathway in children with Henoch-Schönlein purpura and its correlation with inflam-matory cytokines]. [PDF]
Chen H, Li F, Tang Y, Zeng P.
europepmc +1 more source
[Causal associations between immune cell phenotypes and Ménière's disease: a bidirectional two-sample Mendelian randomization study and validation in mice]. [PDF]
Yang L, Yu J, Han L, Dai J.
europepmc +1 more source
[IOX1 alleviates hepatic ischemia-reperfusion injury by inhibiting mitogen-activated protein kinase signaling pathway]. [PDF]
Hu SC +7 more
europepmc +1 more source
[Research progress on maternal factors influencing the risk of autism spectrum disorder in offspring from a gut-brain axis perspective]. [PDF]
Ding HB, Li C, Wu SL.
europepmc +1 more source
[Interferon-α induces disulfidptosis occurrence in human liver cancer cells]. [PDF]
Bi XY +5 more
europepmc +1 more source

