野生动物学报, 2010 利用15个微卫星标记对麋鹿、黇鹿、梅花鹿、黄麂、马鹿5种鹿类动物群体DNA多态性进行测定,共检测到95个等位基因,平均等位基因数和群体有效等位基因数分别为6..3333±2.7946个和4.7089±1.8355个,平均期望杂合度为0.5790±0.1025,平均多态信息含量为0.4483±0.1050。群体间的平均遗传分化为29.4 ...
李文斌, 闻亮, 郑维平, 徐永山
doaj
野生动物学报小飞鼠（Pteromys volans）为树栖夜行滑行类啮齿动物，过去不合理的森林采伐已导致其生存受到一定威胁，亟需对其种群的遗传变化，特别是遗传多样性和近交衰退等种群遗传信息开展进一步评价，增强保护与管理的针对性。利用微卫星分子标记对黑龙江省南部4个小飞鼠种群进行遗传多样性分析。结果显示：8个微卫星位点检测出种群平均等位基因数为12.9（12.0 ~ 14.4）个，有效等位基因数为8.6（8.1 ~ 8.8）个，观测杂合度为0.887（0.832 ~ 0.925），期望杂合度为0.872（0.865 ~
田新民 +3 more
doaj
Single-cell and spatial transcriptomic analysis reveals that an immune cell-related signature could predict clinical outcomes for microsatellite-stable colorectal cancer patients receiving immunotherapy. [PDF]
J Zhejiang Univ Sci BYuan S +13 more
europepmc +1 more source
[Estradiol<b>-</b>ERβ signaling axis promotes myofiber repair in female mice with acute skeletal muscle inflammation by regulating IGF<b>-</b>1 expression from M2 macrophages]. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanLiao Z +8 more
europepmc +1 more source
[Development and validation of a multicenter nomogram predicting the risk of liver metastasis after curative resection of colorectal cancer]. [PDF]
Beijing Da Xue Xue Bao Yi Xue BanWang N, Yuan D, Zhu Y, Ding L.
europepmc +1 more source
野生动物学报遗传多样性和亲缘关系的研究对于野生动物种群的健康维持和长久繁衍具有重要意义。为评估三江源国家公园长江源园区藏原羚（Procapra picticaudata）种群的遗传多样性，本研究共采集24个藏原羚集群的149份新鲜粪便样本，利用MB066、HDZ8、HDZ496等8个微卫星位点进行基因分型，最终识别出105个藏原羚个体，并利用性别鉴定引物确定其中有雌性77只，雄性28只。结果表明：8个微卫星位点的平均等位基因数为21.125，平均多态信息含量（PIC）为0.708，观测杂合度（Ho）为0.219~0.
李其琴 +4 more
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[Clinicopathological and molecular features of acquired cystic kidney disease and associated renal cell carcinoma]. [PDF]
Beijing Da Xue Xue Bao Yi Xue BanLiu H, Guo W, Shi S, He H.
europepmc +1 more source
[Advances in the role of miR-378a in skeletal muscle development and diseases]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiDing ZT, Lan D.
europepmc +1 more source
野生动物学报为了探究秦岭大熊猫（Ailuropoda melanoleuca qinlingensis）圈养种群的遗传多样性和亲子关系，指导其科学繁育，本研究建立了一套优化的技术体系。利用筛选出的9个高分辨率微卫星位点（以四碱基重复为主）进行PCR扩增与毛细管电泳分型，并对32只个体进行遗传多样性分析。结果显示：通过均质化与热孵育预处理，显著提升了粪便样本中宿主基因组DNA的得率与质量。秦岭大熊猫群体Ho为0.281 ~0.938，平均为0.596，He为0.391 ~ 0.793，平均为0.560， Ho >
刘晨阳 +8 more
doaj
[<i>Qingda</i> Granules inhibit cerebral microvascular endothelial cell apoptosis in hypertensive mice by suppressing the P53 signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLin Y +8 more
europepmc +1 more source