Results 101 to 110 of about 1,893 (176)

基于微卫星标记的藏原羚遗传多样性及亲缘关系分析

野生动物学报
遗传多样性和亲缘关系的研究对于野生动物种群的健康维持和长久繁衍具有重要意义。为评估三江源国家公园长江源园区藏原羚（Procapra picticaudata）种群的遗传多样性，本研究共采集24个藏原羚集群的149份新鲜粪便样本，利用MB066、HDZ8、HDZ496等8个微卫星位点进行基因分型，最终识别出105个藏原羚个体，并利用性别鉴定引物确定其中有雌性77只，雄性28只。结果表明：8个微卫星位点的平均等位基因数为21.125，平均多态信息含量（PIC）为0.708，观测杂合度（Ho）为0.219~0.
李其琴, 王东, 李全邦, 杜文晓, 连新明   +4 more
doaj   +2 more sources

Single-cell and spatial transcriptomic analysis reveals that an immune cell-related signature could predict clinical outcomes for microsatellite-stable colorectal cancer patients receiving immunotherapy. [PDF]

J Zhejiang Univ Sci B
Yuan S, Xia Y, Dai G, Rao S, Hu R, Gao Y, Qiu Q, Wu C, Qiao S, Xu Y, Xie X, Lou H, Wang X, Zhang J.   +13 more
europepmc   +1 more source

[Potential biological mechanisms underlying spaceflight-induced depression symptoms in astronauts]. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Li Z, Liu J, Liu B, Wang M, Ju Y, Zhang Y.   +5 more
europepmc   +1 more source

基于微卫星的大熊猫群体遗传多样性分析及亲子鉴定

野生动物学报
为了探究秦岭大熊猫（Ailuropoda melanoleuca qinlingensis）圈养种群的遗传多样性和亲子关系，指导其科学繁育，本研究建立了一套优化的技术体系。利用筛选出的9个高分辨率微卫星位点（以四碱基重复为主）进行PCR扩增与毛细管电泳分型，并对32只个体进行遗传多样性分析。结果显示：通过均质化与热孵育预处理，显著提升了粪便样本中宿主基因组DNA的得率与质量。秦岭大熊猫群体Ho为0.281 ~0.938，平均为0.596，He为0.391 ~ 0.793，平均为0.560， Ho >
刘晨阳, 王晓宇, 张美晗, 张文涛, 张丹辉, 沈洁娜, 雷颖虎, 昝林森, 成功   +8 more
doaj  

[Sulforaphane reduces reactive astrocyte-mediated neuron apoptosis <i>in vitro</i> by inhibiting the MAPK/NF-κB signaling pathway in Aβ42 oligomer-activated astrocytes]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhang S, Huang T, Yang C, Chen J, Lü T, Zhang J.   +5 more
europepmc   +1 more source

基于微卫星标记的雪豹种群结构及遗传多样性

野生动物学报
掌握雪豹（Panthera uncia）的遗传多样性信息对其保护和管理有重要意义。对104只雪豹个体的组织样品提取DNA，结合文献中提供的70个雪豹基因分型数据，利用9个微卫星多态性位点进行遗传多样性研究。结果显示：当样本量从70个增加到174个时，雪豹种群有分化为2个种群的趋势，即西北部群和中部群；共检测到45个等位基因（Na），中部、西北部2个种群平均每个位点Na分别为4.556和4.667，平均期望杂合度（He）分别为0.574和0.591，平均观测杂合度（Ho）分别为0.517和0.498 ...
周颖娜, 李金霖, 马跃, 王震
doaj  

[Risks, mechanisms, and prevention strategies for cerebrovascular diseases in lunar astronauts under deep]. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Tang L, Tang Q, Li Y, Wang L, Zhang F, Zhang X, Liu R, Zhang L.   +7 more
europepmc   +1 more source

[Type 2 diabetes patients use E-health to manage disease willingness and influence mechanisms]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Chen Z, Zhang X, Gu Y, Chang C.
europepmc   +1 more source

[Guideline for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal infectious pneumonia (2025)]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Subspecialty Group of Neonatology, Society of Pediatrics, Chinese Medical Association; Ultrasound Group, Neonatologist Subdivision of Chinese Medical Doctor Association; Editorial Board of Chinese Journal of Contemporary Pediatrics.   +3 more
europepmc   +1 more source

[Research progress in the role of STMN1 in tumor]. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Ma X, Li M, Chen, Mei H, Rong Z.
europepmc   +1 more source