, 2016 接种疫苗是预防H5N1禽流感爆发的有效手段，H5N1流感疫苗免疫原性较差，抗原用量高，需要添加佐剂以提高疫苗效果。壳聚糖微球作为颗粒型佐剂具有良好的生物相容性和免疫刺激性。然而，壳聚糖微球的制备及其作为疫苗佐剂的应用还存在以下的需求与问题：1）传统的壳聚糖微球制备方法（如机械搅拌法、凝聚法等）所制备的微球粒径不均一，产品的稳定性与重复性差；2）与包埋相比，抗原吸附过程简单，在细胞内易于释放抗原，而高抗原吸附率要求制备阳离子性、网络多孔的壳聚糖微球，以增大抗原与微球的接触面积与结合力；3 ...
王月琦
core
[Succinate Dehydrogenase-Deficient Renal Cell Carcinoma: Clinicopathological Analysis of 11 Cases]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanPan X +7 more
europepmc +1 more source
[Expert consensus on the implementation of enhanced recovery after surgery in percutaneous endoscopic interlaminar lumbar decompression/discectomy (2020)]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2020 The Group Of Minimally Invasive Spinal Surgery And Enhanced Recovery Professional Committee Of Orthopedic Surgery And Enhanced Recovery Association Of China Rehabilitation Technology Transformation And Promotion.
europepmc +1 more source
, 2009 本发明涉及微生物油脂的生产，具体地说是一种提高微生物油脂发酵生产效率的方法，将产油酵母菌种子液接种于发酵液中，在发酵期间添加醇类化合物，醇类化合物于发酵液中的浓度为0.01-5.0mM，其添加时间为发酵液接种后的0-40h，待发酵液中总还原糖浓度降至1g/L以下时停止培养，离心收集菌体，经有机溶剂抽提获得微生物油脂；与不加入醇类化合物的对照组比较，菌体生物量、油脂含量和脂肪得率系数增率分别达 0.6％-5.7％、0.2％-7.4％和1.4％-13.2％，发酵时间缩短2.8％-27.1％。其切实有效 ...
武 双, 赵宗保
core
[Down-regulation of miR-381-3p inhibits osteogenic differentiation of mouse embryonic palatal mesenchymal cells in 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced cleft palate of fetal mice]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2019 Jiang H, Yuan X, Fu Y.
europepmc +1 more source
[Synthesis and cell biological properties of polyaspartic acid drug/gene vector]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2019 Shen J, Wang Q, Gao D, Lyu Y, Tang G.
europepmc +1 more source
[Successful treatment of two cases of decompensated liver cirrhosis underlying with pulmonary aspergillosis infection]. [PDF]
Zhonghua Gan Zang Bing Za Zhi, 2018 Guo RX +5 more
europepmc +1 more source
[Hereditary vitreous degeneration muddy: report of ten cases]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2016 Shen Z, Gao E, Weng W, Luo W.
europepmc +1 more source
[Clinical features and MYO5B mutations of a family affected by microvillus inclusion disease]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2017 Cheng Y +5 more
europepmc +1 more source
[Influence of endoplasmic reticulum stress on smoking-induced nucleus pulposus cells apoptosis and inflammatory response]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2019 Hou X, Xu L, Yi W, Chen Y, Shen J.
europepmc +1 more source