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ARID1B基因缺失促进NSCLC细胞的增殖、迁移和侵袭能力的研究
Zhongguo fei ai za zhi = Chinese journal of lung cancer背景与目的 SWI/SNF染色质重塑复合物(switch/sucrose nonfermentable chromatin-remodeling complex)的异常与多种癌症密切相关,ARID1B(AT-rich interaction domain 1B)是SWI/SNF复合物的核心亚基之一。ARID1B基因突变或拷贝数缺失与DNA损伤反应受损、染色质可及性改变有关。然而,ARID1B缺失是否影响非小细胞肺癌(non-small cell lung cancer, NSCLC)细胞的增殖 ...
Linlin Zhu, Xuchao Zhang
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