血管紧张素Ⅱ及醛固酮阻滞剂对心肌梗死大鼠骨桥蛋白表达的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2007 【目的】研究血管紧张素Ⅱ及醛固酮阻滞对心肌梗死大鼠非梗死区心肌组织骨桥蛋白（OPN）表达的影响。【方法】将心肌梗死后24h存活大鼠随机分为3组：盐水组（15只，5mL／d），培哚普利组（18只，2mg／kg·d）和螺内酯组（17只，20mg／kg）。灌胃给药；另设假手术组（15只）作对照。分别于心肌梗死后6周：导管法测定左室有创血流动力学；组织学方法检测非梗死区胶原纤维沉积和心肌细胞横径；Western blot检测非梗死区心肌组织OPN表达。【结果】①假手术组大鼠心肌组织Western ...
张玉玲, 周淑娴, 雷娟, 张静敏
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彩色多普勒超声在急性心肌梗死及其并发症诊断中的应用 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2004 【目的】评价彩色多普勒超声心动图在急性心肌梗死及其并发症诊断中的应用价值?【方法】 分析本院120例住院急性心肌梗死患者的临床及超声心动图资料?【结果】 超声心动图检出心肌梗死112例,并发症27例(室壁瘤10例,左室附壁血栓2例,室间隔穿孔2例,中?重度二尖瓣返流13例);超声心动图与心电图对广泛前壁和前壁心肌梗死部位及范围的估测高度一致;超声心动图估测心肌梗死部位与冠状动脉造影所示病变血管供血区域基本相符;非单一部位心肌梗死时,超声心动图较易漏诊下壁或右室梗死?【结论 ...
王景峰, 张小玲
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阿托伐他汀对心室重塑和心肌 AVP、TGF-β1的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2020 【目的】探讨阿托伐他汀能否通过抑制AVP的分泌而延缓心肌纤维化，为改善心肌梗死后心室重塑提供新思路。【方法】通过结扎大鼠冠状动脉前降支建立大鼠心肌梗死模型。建模成功后将大鼠分为假手术组（sham组）、心肌梗死大鼠安慰剂治疗组（MI组）及心肌梗死大鼠阿托伐他汀治疗组（A组），每组各有10只大鼠。干预5周后，超声心动图检测大鼠心功能；处死大鼠后，收集心肌组织标本，计算左心室质量指数；ELISA法检测左心室非梗死区和血清的血管加压素（AVP）含量；Masson染色检测心肌间质纤维化水平 ...
翟原生 +7 more
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罗格列酮对心肌梗死大鼠血流动力学及肾素-血管紧张素系统的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2004 【目的】探讨过氧化物酶体增殖物激活受体γ(PPARγ)激动药罗格列酮对心肌梗死大鼠血流动力学及肾素-血管紧张素系统的影响。【方法】45只SD大鼠随机分为假手术组(9只)和心肌梗死组(36只),将制作心肌梗死模型后24h仍存活的21只SD大鼠随机分为心肌梗死对照组(10只)和罗格列酮组(11只)。罗格列酮组术后24h开始给予罗格列酮3mg/(kg·d)共8周。8周后测定血流动力学,称量心脏、左室、右室、肺和肝质量,用放射免疫法测定血浆及心肌血管紧张素Ⅱ、醛固酮以及血浆肾素活性。【结果】与心肌梗死对照组相比,
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Prediction and Management of People at High Risk of Sudden Death after Myocardial Infarction Who are not Covered by Guidelines [PDF]
, 2022 The prevention of sudden cardiac death after myocardial infarction in contemporary clinical practice primarily relies on the evaluation of left ventricular ejection fraction (LVEF) .
HUANG Baotao
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Critical Left Ventricular Ejection Fraction and Its Possible Pathogenesis in STEMI Patients with Supra-normal Ejection Fraction after Primary PCI [PDF]
, 2022 BackgroundLeft ventricular ejection fraction (LVEF) is often used as an assessment indicator for left ventricular systolic function. As adverse events occur in some patients with preserved LVEF, other phenotypes based on LVEF may exist in the population ...
HAO Xiao, ZHAO Mei, LI Shuren
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CT评价经皮左室分区术对心尖部室壁瘤形成的缺血性心肌病患者心功能的影响 [PDF]
, 2018 心尖部室壁瘤是临床上常见的疾病,发病早期如果得不到及时有效的治疗,将会引起心力衰竭、心脏破裂、缺血性心肌病及栓塞等并发症,主要是由于冠状动脉粥样硬化引起的心肌梗死造成[1]。文献[2,3]报道显示:部分冠状动脉正常患者也可以引发心肌梗死后室壁瘤。数据报道显示[4,5]:每年全球约有1 700万人死于心血管疾病,并且一半以上死于急性心肌梗死,对于存活患者液容易演变为慢性心力衰竭 ...
姜宁宁 +5 more
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Clinical Effect of Early Application of Self-prescribed Yiqihuoxue Decoction on Prevention and Treatment of Depressive Symptoms after Acute Myocardial Infarction [PDF]
, 2022 BackgroundPost-acute myocardial infarction (AMI) patients are prone to depression and other negative emotions. Current treatment for post-AMI patients with depression is anti-myocardial infarction treatment plus anti-depression treatment, in the ...
WANG Mengxi, LIU Qian, SHEN Le, CHEN Xiaohu
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Effect of Dapagliflozin on the Risk of New-onset Atrial Fibrillation during Hospitalization for Acute Myocardial Infarction in Patients with Type 2 Diabetes [PDF]
, 2022 BackgroundAtrial fibrillation is a common complication of acute myocardial infarction with an incidence varying from 5% to 20%. New-onset atrial fibrillation developing after acute myocardial fibrillation indicates a significantly increased risk of death
ZHENG Rujie, WANG Yue, JIANG Yaohui, ZHANG Jinying
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Development and application of CK-MB specific monoclonal antibodies [PDF]
, 2017 本研究拟建立肌酸激酶同工酶MB(CK-MB)特异性单克隆抗体(mAb)的研制方法,对抗CK-MB单抗进行评价分类及性质鉴定,并初步建立CK-MB; 定量检测试剂。以CK-MB抗原免疫BALB/c小鼠,利用常规单抗制备技术,使用间接和捕获ELISA差异筛选法筛选单抗。利用肌酸激酶同工酶(CK-; MM/BB/MB)抗原对所制备单抗的抗原识别表位进行鉴定,另通过免疫印迹法及合成CK-MM、CK-BB差异性的线性表位肽鉴定对所制备的单抗进行评; 价分类。使用双抗体夹心ELISA方法筛选检测CK ...
周国梁 +7 more
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