Results 81 to 90 of about 5,548 (192)
Zhongguo shiyan zhenduanxue, 2005 目的研究大鼠心肌梗死后心肌转化生长因子β1（TGF-β1）与Ⅰ型胶原表达,并测定大鼠血浆内TGF-β1的含量。方法结扎左冠状动脉建立大鼠心肌梗死模型,采用ELISA法测定心肌梗死不同时间内大鼠血浆内TGF-β1的含量;应用免疫荧光染色的方法,通过激光扫描共聚焦显微镜观察TGF-β1与Ⅰ型胶原表达的变化。结果大鼠心梗后1 d3、d5、d血浆内TGF-β1含量明显增加 ...
艾永顺, 李淑梅, 王越晖
doaj
Zhongshan Daxue xuebao. Yixue kexue ban, 2004 【目的】探讨一种新的大鼠心肌梗死模型制作方法。［方法）大鼠麻醉后，经口腔插管连通动物呼吸机，切开胸廓暴露心脏，电凝烧灼其左冠状动脉前降支。然后千12 h,2 d和2周后将大鼠处死，取出心脏，显微镜下观察其病理变化。对照组使用冠状动脉结扎法制作心肌梗死模型。【结果】在电凝烧灼大鼠冠状动脉后，大鼠 心肌组织出现凝固性坏死，继而有肉芽组织长入梗死灶内，最后形成疤痕。 用电凝烧灼法可成功复制心肌梗死 大鼠动物模型。 与冠状动脉结扎法相比较，操作简单，手术时间短，死亡率低。［结论l电凝烧灼法作为一种复制 ...
doaj
Zhongguo shiyan zhenduanxue, 2007 目的急性心肌梗死早期测定脑钠肽（BNP）在评价梗死后近期预后的临床价值。方法急性心肌梗死患者急性期和恢复期分别测定BNP浓度、左室射血分数（LVEF）,并将患者分为LVEF≤40%组和LVEF>40%组,死亡组和非死亡组,并进行BNP浓度比较。结果LVEF≤40%组、死亡组BNP浓度显著高于LVEF>40%组 ...
张书广
doaj
[Nilotinib-loaded gelatin methacryloyl microneedles patch for the treatment of cardiac dysfunction after myocardial infarction]. [PDF]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2023 Peng N, Xie J.
europepmc +1 more source
Trends in incidence and mortality of acute myocardial infarction in Xiaoshan District， Hangzhou City from 2017 to 2023 [PDF]
ObjectiveTo analyze the incidence rate and mortality of acute myocardial infarction (AMI) and their changing trends among the registered residents in Xiaoshan District, Hangzhou City from 2017 to 2023, so as to provide references for formulating policies
GAO Yuanyuan +7 more
core +1 more source
[Cardiac progenitor cells-derived exosomes alleviate myocardial injury by regulating Treg cell differentiation through the mTOR pathway in mice with myocardial infarction]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 He Y, Li Z, Shen L, Shi D, Li S.
europepmc +1 more source
PRKCI基因在急性心肌梗死患者外周血白细胞中低表达及其临床意义
Zhongguo shiyan zhenduanxue, 2016 心肌梗死的发病率越来越高,且有年轻化的趋势。全基因组关联研究发现,基因的碱基突变可能是导致急性心肌梗死发生的原因之一[1-5]。课题组基因芯片研究发现,有559个基因在急性心肌梗死患者中的表达发生改变[6]。其中,PRKCI基因为显著低表达,P=0.003517699,LogFC=-1.563554087 ...
范琳, 孟赫禹, 孟繁波
doaj
心衰鼠肺水通道蛋白表达变化及内皮素受体拮抗剂对其的影响 [PDF]
, 2002 【目的】观察充血性心力衰竭大鼠肺组织水通道蛋白(Aquaporins, AQP)表达的变化及选择性内皮素受体A(endo thelin recepto r A , ETA)拮抗剂FR139317 对其的影响。【方法】40 只行左冠状动脉结扎致心肌梗死的大鼠随机分为心衰组 和心衰治疗组, 心衰治疗组予以FR139317 每天1 mg/kg 皮下注射, 共6 周, 另7 只接受假手术的大鼠组成空白对照组。测定 血液动力学参数, 放射免疫法(RIA)测血浆内皮素-1 浓度, 逆转录-聚合酶链反应(RT ...
刘英梅, 张旭明, 陈筱潮
core
Prognostic value of serum growth differentiation factor-15, brain natriuretic peptide and adiponectin in patients with acute myocardial infarction [PDF]
Objective To investigate the expression levels of serum growth differentiation factor-15 (GDF-15), brain natriuretic peptide (BNP), and adiponectin (APN) in patients with acute myocardial infarction (AMI) and their prognostic evaluation value.
GU Peipei*, WANG Haitao, WEI Xiaohui
core +2 more sources