Results 11 to 20 of about 1,150 (97)
Zhongshan Daxue xuebao. Yixue kexue ban, 2015 摘 要: 【目的】 探讨SIRT6通过调节内皮一氧化氮合酶(eNOS)抑制苯肾上腺素(PE)诱导的新生大鼠心肌细胞肥大的作用及机制? 【方法】 在PE诱导的心肌细胞肥大模型中采用si-RNA干扰或腺病毒过表达的方法改变心肌细胞中SIRT6表达水平,并通过实时定量RT-PCR(real time PCR)?Western Blotting等方法检测心肌肥大基因心钠素(ANF)?脑尿钠肽(BNP)的表达?心肌细胞表面积,以及eNOS的表达及NO的生成?
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Zhongshan Daxue xuebao. Yixue kexue ban, 2010 目的】 研究AMP激活的蛋白激酶 (AMPK)及血红素氧合酶HO-1激活对心肌肥大的影响,以及HO-1在AMPK抑制心肌肥大中的作用?【方法】 以培养的新生大鼠心肌细胞为研究对象,采用蛋白免疫印迹杂交方法检测5-氨基-4甲酰胺咪唑核糖核苷酸(AICAR)对AMPK的磷酸化程度及对HO-1的影响,并测定心肌细胞 [3H]-亮氨酸掺入率及心肌细胞表面积,观察AMPK及HO-1心肌细胞肥大的影响?【结果】 AICAR对AMPK及HO-1均有激活作用,AICAR能阻断AngⅡ引起的心肌肥大效应;阻断HO ...
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Advances in biological activities of rape bee pollen and its development and utilization [PDF]
, 2023 The research and development value of rape bee pollen, a natural health raw material, is increasing as public awareness of health issues develops.
CHEN Simin +5 more
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Research Progress on Pathological Fibrosis of Sinoatrial Node [PDF]
, 2021 Human heart rhythm is mainly regulated and controlled by the sinoatrial node. Fibrosis plays an important regulating role in adjusting the structural and functional integrity of the sinoatrial node pacemaker complex.
WANG Wei, ZHANG Shi-lin, LIU Fang-fang, et al.
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Study the correlation of FIB-4 and sST2 levels with heart failure [PDF]
, 2023 Objective To investigate the correlation between hepatic fibrosis index-4 （FIB-4） and soluble growth stimulating gene 2 protein （sST2） with the incidence and severity of heart failure.
Tao Xuejiao, Lu Junkun, Chen Jiahui, Gao Yujin
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Critical Left Ventricular Ejection Fraction and Its Possible Pathogenesis in STEMI Patients with Supra-normal Ejection Fraction after Primary PCI [PDF]
, 2022 BackgroundLeft ventricular ejection fraction (LVEF) is often used as an assessment indicator for left ventricular systolic function. As adverse events occur in some patients with preserved LVEF, other phenotypes based on LVEF may exist in the population ...
HAO Xiao, ZHAO Mei, LI Shuren
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Regulatory effect of 3'-tRF-PheGAA on Ang Ⅱ-induced cardiomyocyte hypertrophy and its mechanism [PDF]
Objective To investigate the regulatory effect of 3'-tRF-PheGAA on angiotensin Ⅱ (Ang Ⅱ)-induced cardiomyocyte hypertrophy and its mechanism. Methods Primary cardiomyocytes of neonatal mice were obtained and cultured for 24 h, and were then divided into ...
CHENG Xueli, WANG Kai, ZHAO Yan, WANG Kun
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基于Postn介导的TGF-β/NF-κB通路探讨绿原酸改善心肌肥大的作用及机制研究
Zhongguo shiyan zhenduanxue, 2022 目的 探究绿原酸介导Postn/TGF-β/NF-κB通路改善心肌肥大的作用机制。方法 采用血管紧张素Ⅱ（AngⅡ）诱导H9c2心肌细胞，构建心肌肥大模型。随机将细胞分为对照组、模型组、Postn-siRNA组、绿原酸组和Postn-siRNA+绿原酸组。测定各组细胞表面积及活性，各组心肌细胞Postn/TGF-β/NF-κB通路相关蛋白和mRNA表达情况，流式细胞术测定各组凋亡率。结果 与对照组比较，模型组细胞表面积和凋亡率明显增大，细胞活性明显减少（P＜0.05）；与模型组比较，Postn ...
卢娜, 金立民, 苑野
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Study on the effect of myocardial injury induced by electrical injury in mice based on metabolomics [PDF]
Objective To study myocardial injury induced by electrical injury in mice based on metabolomics, and to find out the differential metabolites and pathways in cardiac metabolism omics.
CHEN Siyu +9 more
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Effects of Bilirubin in Rapid Atrial Pacing Rabbit on Atrial Electrophysiology and Oxidative Stress [PDF]
, 2013 背景心房颤动（房颤，atrialfibrillation，AF）是常见的心律失常之一，较为复杂，其发生和维持机制确尚未完全阐明。近年来研究表明氧化应激可引起心房重构进而促进房颤的发生发展。胆红素（Bilirubin，BR）是一种内源性的强抗氧化剂，研究表明其在体外与动物心肌细胞共培养，可阻止心肌细胞重构，而关于胆红素对房颤或快速心房起搏动物模型心房组织电重构的影响则尚未有报导。 目的建立快速心房起搏（RapidAtrialPacing，RAP）家兔模型，将胆红素作用于此模型 ...
张蓉芳
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