Zhongshan Daxue xuebao. Yixue kexue ban, 2011 【目的】 观察钙瞬变交替在快速心房起搏的犬心房肌细胞中的变化情况,探讨钙瞬变交替在房颤形成中的作用【方法】制成快速心房起搏的致房颤犬动物模型,分成快速心房起搏组与对照组分离心房肌细胞,使用激光扫描共聚焦显微镜测定在不同频率的电场刺激下,心房肌细胞的钙瞬变及钙瞬变交替出现的阈值频率【结果】快速心房起搏组心房肌细胞钙瞬变交替的阈值频率(min-1)明显低于对照组(86 ± 17 vs 123 ± 11,P < 0.01),同时易产生亚细胞非同步性钙瞬变交替在30 min-1的频率刺激下 ...
doaj
[MiR-224-5p overexpression inhibits oxidative stress by regulating the PI3K/Akt/FoxO1 axis to attenuate hypoxia/reoxygenation-induced cardiomyocyte injury]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLiang G, Tang H, Guo C, Zhang M.
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[Compound Yuye Decoction protects diabetic rats against cardiomyopathy by inhibiting myocardial apoptosis and inflammation via regulating the PI3K/Akt signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhang W +5 more
europepmc +1 more source
[Resveratrol alleviates hyperglycemia-induced cardiomyocyte hypertrophy by maintaining mitochondrial homeostasis via enhancing SIRT1 expression]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoYe H +6 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2010 目的】 研究AMP激活的蛋白激酶 (AMPK)及血红素氧合酶HO-1激活对心肌肥大的影响,以及HO-1在AMPK抑制心肌肥大中的作用?【方法】 以培养的新生大鼠心肌细胞为研究对象,采用蛋白免疫印迹杂交方法检测5-氨基-4甲酰胺咪唑核糖核苷酸(AICAR)对AMPK的磷酸化程度及对HO-1的影响,并测定心肌细胞 [3H]-亮氨酸掺入率及心肌细胞表面积,观察AMPK及HO-1心肌细胞肥大的影响?【结果】 AICAR对AMPK及HO-1均有激活作用,AICAR能阻断AngⅡ引起的心肌肥大效应;阻断HO ...
doaj
[Palmitic acid suppresses autophagy in neonatal rat cardiomyocytes via the cGAS-STING-IRF3 pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2022 Yu H, Liu Q, Guo Y, Xia Y, Luo S.
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双氢青蒿素对血管紧张素Ⅱ诱导的心肌成纤维细胞分泌胶原及激活PI3K/AKT通路的影响 附视频
Zhongguo shiyan zhenduanxue心肌纤维化常由于心脏多次短暂缺血、负荷过重、心肌炎等多种有害因素所致。研究显示心肌组织中的胶原异常沉积为心肌纤维化病理学特征[1-2],引起心肌硬度增加、收缩能力下降,易发生心律失常、心室重构以及心功能不全等并发症。心肌成纤维细胞数量增多和异常活化释放大量基质成分为心肌纤维化的重要机制,也是疾病治疗的关键点[3-4]。实验表明血管紧张素Ⅱ（angiotensin Ⅱ,Ang Ⅱ）是促进心肌发生纤维化的重要因子[5-6]。本研究采用AngⅡ孵育心肌成纤维细胞制备细胞模型,经双氢青蒿素（DHA）干预后 ...
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[Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoPeng Y +6 more
europepmc +1 more source
[Shihu Mixture alleviates diabetic cardiomyopathy in rats by Sirt3-mediated upregulation of myocardial mitochondrial mitophagy pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLin X, He Y, Shi H, Liu J, Hu H.
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Role for phosphatidylinositol 4-kinase IIIβ in cardiac metabolic diseases [PDF]
, 2020 Sun, Aomin
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