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【目的】 观察不同颗粒大小滑石粉胸膜固定术后肺及肺外器官的播散变化,以初步探讨滑石粉相关急性呼吸窘迫综合征(ARDS)的发生机制。【方法】 建立滑石粉胸膜固定术的实验动物模型,将36只健康雄性清洁级新西兰白兔按随机数字表法分为3组:大滑石粉组(n= 12)、小滑石粉组(n = 12)和多西环素(Doxycycline)组(n = 12)。实验动物经胸腔导管各注入大、小滑石粉匀浆(400 mg/kg)和多西环素(10mg/kg),引起兔子右侧胸膜炎症及粘连。分别于胸膜粘连术后24 ...
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