Tripterygium wilfordii attenuates acute lung injury by regulating the differentiation and function of myeloid-derived suppressor cells. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban目的 急性肺损伤(acute lung injury，ALI)是以气体交换功能障碍为特点的急性呼吸功能不全综合征。由于缺乏有效的针对性药物，患者病死率高，总体预后较差。雷公藤(Tripterygium wilfordii，TW)在治疗多种疾病时表现出抗炎活性。本研究旨在探讨TW在ALI过程中对骨髓源性抑制细胞(myeloid-derived suppressor cells，MDSCs)的影响及其作用机制，以期为TW作为ALI的潜在辅助治疗药物提供实验依据。 方法 将18只无特定病原体(specific
Wei L, Tong S, Wang M, Ren H, Wang J.
europepmc +2 more sources
[Itaconic acid alleviates macrophage PANoptosis in sepsis-associated acute lung injury via inhibiting ninjurin-1-mediated plasma membrane rupture]. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban目的 脓毒症急性肺损伤(sepsis-associated acute lung injury，S-ALI)是加强监护病房(intensive care unit，ICU)患者的重要致死原因之一，其发病机制尚未完全阐明，仍缺乏有效的治疗措施。巨噬细胞溶解性细胞死亡是S-ALI炎症级联反应的关键病理机制。其中，泛凋亡(PANoptosis)是以泛凋亡小体组装及激活为特征的新型溶解性细胞死亡方式，而神经损伤诱导蛋白1(ninjurin 1，NINJ1)作为一种新型膜成孔蛋白，在泛凋亡质膜破裂(plasma ...
Chen M +5 more
europepmc +2 more sources
Zhongshan Daxue xuebao. Yixue kexue ban急性肺损伤（ALI）是一种严重威胁全球人类生命健康的疾病，其主要病理特征为肺泡上皮细胞和肺毛细血管内皮细胞的损伤，导致弥漫性肺间质水肿和肺泡水肿，通常伴有急性低氧性呼吸功能不全。内质网应激（ERS）在ALI的发生和发展过程中扮演着关键角色。它通过多种途径加剧急性肺损伤：在细胞凋亡方面，关键蛋白如GRP78、CHOP和caspase-12参与调控，促进肺血管内皮细胞和肺泡上皮细胞的凋亡，从而加重肺组织损伤；在ROS代谢方面，诱导活性氧（ROS）的大量释放，NADPH氧化酶等参与ROS的产生过程 ...
韩英, 胡丹丹
doaj +6 more sources
Changes and significance of TLR7/9 and IFN-Ⅰ levels in children with severe mycoplasma pneumoniae pneumonia [PDF]
, 2023 Objective To investigate the changes and significance of Toll-like receptor 7 （TLR7）， TLR9 and type I interferon （IFN-Ⅰ） in children with severe mycoplasma pneumoniae pneumonia （SMPP）.
Yan Jiangxue, Ding Xia, Jiao Qiongjie, Huang Li, Cao Nannan, Dong Xinfang, Ni Qian
core +1 more source
Structure of an Acidic Polysaccharide from Brassica rapa L. and Its Protective Effect on Lipopolysaccharide-Induced Lung Injury in Mice [PDF]
, 2023 Objective: To study the structure of BRAP-1, an acidic polysaccharide from Brassica rapa L. and its effect and mechanism on lipopolysaccharide (LPS)-induced lung injury in mice.
Kadierya·KUERBAN, Ajiranmu·Abula, CHEN Zhuo’er, Miherenisha·AMUREJIANG, Hailiqian·TAOERDAHONG, YANG Fei
core +1 more source
, 2021 目的观察糖尿病合并脓毒症小鼠肠损伤特点，并初步探讨M1巨噬细胞在糖尿病合并脓毒症肠损伤中的作用。方法BKS-DB（Lepr ko/ko）和BKS-DB（Lepr wt/wt）雄性小鼠随机分为非糖尿病鼠假手术组（NDMS组）、非糖尿病鼠脓毒症模型组（NDMCLP组）、糖尿病鼠假手术组（DMS组）、糖尿病鼠脓毒症模型组（DMCLP组）4组，每组6只；细胞实验分为对照组（Sham组）、高糖组（HG组）、脂多糖组（LPS组）、高糖+脂多糖组（HG+LPS组）4组。采用盲肠结扎穿孔术（CLP ...
庞昌季 +5 more
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Journal of Advanced Nursing, Volume 75, Issue 12, Page 3404-3423, December 2019., 2019 Abstract Aims To examine the association between nurse skill mix (the proportion of total hours provided by Registered Nurses) and patient outcomes in acute care hospitals. Design A quantitative systematic review included studies published in English between January 2000 – September 2018.
Diane E. Twigg +3 more
wiley +1 more source
The Study of the Value of High Mobility Group Protein B1 Combined with Acute Physiological Score in the Diagnosis and Prognosis of Children with Severe Pneumonia [PDF]
, 2022 BackgroundSevere pneumonia in children is a common respiratory critical illness, and accurate assessment of its prognosis is the key to reasonable clinical decision-making. High mobility group protein B1 (HMGB1) and acute physiology score (APS) have high
KANG Ping, LI Yi, TANG Yu
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Application of Biomarker Detection of Exhaled Air Condensate in Respiratory Diseases [PDF]
, 2022 Respiratory diseases are getting more and more attention, and their complex and changeable symptoms have brought a series of challenges to medical treatment.
XU Baichuan, LI Yiting, ZHAO Hulei, ZHANG Peng, XIE Yang
core +1 more source
Recent Developments in Stem Cells from Human Exfoliated Deciduous Teeth in the Treatment of Non-oral Diseases [PDF]
, 2023 Stem cells from human exfoliated deciduous teeth (SHEDs) are odontogenic stem cells with strong proliferation ability and multilineage differentiation potential.
JIANG Zhihan, XU Ling
core +1 more source