Zhongshan Daxue xuebao. Yixue kexue ban急性肺损伤（ALI）是一种严重威胁全球人类生命健康的疾病，其主要病理特征为肺泡上皮细胞和肺毛细血管内皮细胞的损伤，导致弥漫性肺间质水肿和肺泡水肿，通常伴有急性低氧性呼吸功能不全。内质网应激（ERS）在ALI的发生和发展过程中扮演着关键角色。它通过多种途径加剧急性肺损伤：在细胞凋亡方面，关键蛋白如GRP78、CHOP和caspase-12参与调控，促进肺血管内皮细胞和肺泡上皮细胞的凋亡，从而加重肺组织损伤；在ROS代谢方面，诱导活性氧（ROS）的大量释放，NADPH氧化酶等参与ROS的产生过程 ...
韩英, 胡丹丹
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Changes and significance of TLR7/9 and IFN-Ⅰ levels in children with severe mycoplasma pneumoniae pneumonia [PDF]
, 2023 Objective To investigate the changes and significance of Toll-like receptor 7 （TLR7）， TLR9 and type I interferon （IFN-Ⅰ） in children with severe mycoplasma pneumoniae pneumonia （SMPP）.
Yan Jiangxue, Ding Xia, Jiao Qiongjie, Huang Li, Cao Nannan, Dong Xinfang, Ni Qian
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Structure of an Acidic Polysaccharide from Brassica rapa L. and Its Protective Effect on Lipopolysaccharide-Induced Lung Injury in Mice [PDF]
, 2023 Objective: To study the structure of BRAP-1, an acidic polysaccharide from Brassica rapa L. and its effect and mechanism on lipopolysaccharide (LPS)-induced lung injury in mice.
Kadierya·KUERBAN, Ajiranmu·Abula, CHEN Zhuo’er, Miherenisha·AMUREJIANG, Hailiqian·TAOERDAHONG, YANG Fei
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, 2021 目的观察糖尿病合并脓毒症小鼠肠损伤特点，并初步探讨M1巨噬细胞在糖尿病合并脓毒症肠损伤中的作用。方法BKS-DB（Lepr ko/ko）和BKS-DB（Lepr wt/wt）雄性小鼠随机分为非糖尿病鼠假手术组（NDMS组）、非糖尿病鼠脓毒症模型组（NDMCLP组）、糖尿病鼠假手术组（DMS组）、糖尿病鼠脓毒症模型组（DMCLP组）4组，每组6只；细胞实验分为对照组（Sham组）、高糖组（HG组）、脂多糖组（LPS组）、高糖+脂多糖组（HG+LPS组）4组。采用盲肠结扎穿孔术（CLP ...
庞昌季 +5 more
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Journal of Advanced Nursing, Volume 75, Issue 12, Page 3404-3423, December 2019., 2019 Abstract Aims To examine the association between nurse skill mix (the proportion of total hours provided by Registered Nurses) and patient outcomes in acute care hospitals. Design A quantitative systematic review included studies published in English between January 2000 – September 2018.
Diane E. Twigg +3 more
wiley +1 more source
The Study of the Value of High Mobility Group Protein B1 Combined with Acute Physiological Score in the Diagnosis and Prognosis of Children with Severe Pneumonia [PDF]
, 2022 BackgroundSevere pneumonia in children is a common respiratory critical illness, and accurate assessment of its prognosis is the key to reasonable clinical decision-making. High mobility group protein B1 (HMGB1) and acute physiology score (APS) have high
KANG Ping, LI Yi, TANG Yu
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Application of Biomarker Detection of Exhaled Air Condensate in Respiratory Diseases [PDF]
, 2022 Respiratory diseases are getting more and more attention, and their complex and changeable symptoms have brought a series of challenges to medical treatment.
XU Baichuan, LI Yiting, ZHAO Hulei, ZHANG Peng, XIE Yang
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Recent Developments in Stem Cells from Human Exfoliated Deciduous Teeth in the Treatment of Non-oral Diseases [PDF]
, 2023 Stem cells from human exfoliated deciduous teeth (SHEDs) are odontogenic stem cells with strong proliferation ability and multilineage differentiation potential.
JIANG Zhihan, XU Ling
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The relationship between serum IL⁃33，vWF，G⁃CSF and prognosis of acute massive hemorrhage patients with transfusion⁃related acute lung injury [PDF]
Objective To explore the predictive value of serum interleukin⁃33（IL⁃33），von Willebrand factor（vWF），and granulocyte colony⁃stimulating factor（G⁃CSF）for the prognosis of acute massive hemorrhage patients withtransfusion⁃related acute lung injury（TRALI ...
DU Dan*，WEI Ge，WANG Lingxue，LIU Hongbin
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ICAM-1对脓毒症所致急性肺损伤与呼吸窘迫综合征的临床诊断和预后评估作用
Zhongguo shiyan zhenduanxue, 2020 目的探讨ICAM-1对脓毒症所致急性肺损伤与呼吸窘迫综合征的临床诊断和预后评估作用。方法选取2018年2月-2019年9月我院收治的脓毒症患者76例,根据其症状表现将其分为单纯脓毒症组43例,合并急性肺损伤组21例,以及同时合并急性肺损伤、呼吸窘迫综合征组12例,分析其ICAM-1水平对于疾病诊断以及预后评估的价值。结果同时合并肺损伤与呼吸窘迫综合征组患者ICAM-1水平以及SOFA评分均高于脓毒症组以及合并肺损伤组 ...
王晓林, 李静, 黄艳丽
doaj