[Role of Histone Modifications in Acute Kidney Injury Progressing to Chronic Kidney Disease]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 急性肾损伤（acute kidney injury, AKI）是由各种因素引起的以肾功能短期内急剧下降为主要表现的临床综合征，其不仅影响患者的短期预后，还可诱发慢性肾脏病（chronic kidney disease, CKD）。然而，目前AKI的治疗仍以对症处理为主，预防AKI向CKD转变的治疗措施非常有限。组蛋白是在染色体中DNA结合的碱性蛋白质。组蛋白翻译后，其氨基尾发生甲基化、乙酰化、磷酸化、泛素化以及乳酸化等各种修饰，构成“组蛋白密码”，主要通过调节染色质的松紧结构或招募特定蛋白影响基因表达 ...
Guo S, Zhang Z, Zhao J, Yuan J, Sun S.
europepmc +2 more sources
Role and mechanism of endoplasmic reticulum stress and NLRP3 inflammasome in acute kidney injury. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban急性肾损伤(acute kidney injury，AKI)是临床常见的危急重症，主要临床症状为肾功能短时间内急剧下降。AKI的发病机制复杂，目前尚未完全阐明。近年来研究发现，内质网应激(endoplasmic reticulum stress，ERS)和Nod样受体蛋白3(Nod-like receptor family pyrin domain containing 3，NLRP3)炎症小体的激活均与AKI的发生密切相关。肾脏受损时，肾细胞内环境稳态被破坏，ERS被激活，过度的ERS可引起肾细胞凋亡，
Pei M, Deng K, Chen Y.
europepmc +2 more sources
Pyroptosis and sepsis-associated acute kidney injury. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban细胞焦亡是一种由炎性半胱氨酸蛋白酶介导的依赖于消皮素(gasdermin，GSDM)家族蛋白在质膜上形成膜孔后触发炎症的程序性死亡方式，GSDM蛋白是细胞焦亡的执行蛋白。细胞焦亡可通过级联效应激活强烈的炎症反应。脓毒症相关急性肾损伤(sepsis-associated acute kidney injury，SA-AKI)是一种经典的炎症性疾病，尚无明确的特效治疗药物。目前，有关细胞焦亡参与SA-AKI发生和发展的研究已有论述，但细胞焦亡作用于肾脏的具体细胞群及调控机制尚未明晰。细胞焦亡可能与SA ...
Xiao C, Li X.
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Role of MARK4 in methamphetamine-induced acute kidney injury. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban目的 甲基苯丙胺(methamphetamine，METH)是一种非法的精神活性物质，可以损害身体的各个器官，其中泌尿系统是其毒性作用的重要靶标之一。本研究旨在探讨微管亲和调控激酶4(microtubule affinity regulating kinase 4，MARK4)在METH诱导急性肾损伤(acute kidney injury，AKI)中的作用。 方法 选取10只健康成年雄性C57BL/6小鼠，随机分为对照组和METH组，每组5只。METH组腹腔注射METH(20 mg/kg，每天1次 ...
Tang J +6 more
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Research progress in the role of gut microbiota in acute kidney injury. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban急性肾损伤(acute kidney injury，AKI)是一个全球性的公共卫生问题，其发病率和病死率高、医疗费用昂贵且治疗手段有限。AKI可进一步转变为慢性肾脏病(chronic kidney disease，CKD)，最终进展为终末期肾病(end-stage renal disease，ESRD)。既往研究表明，创伤、药物的不良反应、手术等与AKI密切相关。随着进一步的深入探索，肠道菌群在AKI中的作用逐渐被揭示。AKI发生后，肠道菌群组成改变，肠道屏障破坏引发肠道免疫以及肠道细菌易位。同时 ...
Chen T +5 more
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[Predicting Intensive Care Unit Mortality in Patients With Heart Failure Combined With Acute Kidney Injury Using an Interpretable Machine Learning Model: A Retrospective Cohort Study]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban目的 开发一种可解释的机器学习模型，以提高心力衰竭（heart failure, HF）合并急性肾损伤（acute kidney injury, AKI）患者短期死亡率的早期预测准确性。 方法 本回顾性队列研究利用了基于电子病历的公开大型数据库重症医学信息数据库MIMIC-Ⅳ（Medical Information Mart for Intensive Care Ⅳ, 版本2.0）。提取了患者入住ICU最初24 h的数据，并将其分为训练集（80%）和验证集（20%）。利用沙普利可加性解释（Shapley
Luo X +5 more
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亚洲临床医学杂志, 2021 急性肾损伤（Acute kidney injury,AKI）是由各种病因引起肾功能在短时间内快速减退而导致的临床综合征。AKI在世界范围内的发病率及死亡率都很高，且花费巨大。AKI已成为慢性肾脏病（Chronic kidney diseases，CKD）进展的一个公认的危险因素。论文主要针对AKI向CKD发展过程中，部分新的生物标志物及如何预防AKI后CKD的进展进行主要阐述，为临床中早期识别AKI患者并实施干预作出一定的依据。
建荣 李
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Clinicopathological Manifestations of Kidney Injury in Leukemia [PDF]
, 2022 BackgroundKidney is a major extramedullary organ involved in leukemia, but clinicians have insufficient understanding of it due to rare case reports.ObjectiveTo analyze the clinicopathological manifestations of kidney injury in leukemia.MethodsFive ...
WANG Yina, DONG Bao, LI Xin, SHAO Chunying, ZUO Li, WANG Mei, YAN Yu
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Predictive value of cystatin C-based estimated glomerular filtration rate combined with thromboelastogram for clinical prognosis of acute-on-chronic liver failure [PDF]
, 2023 Objective To investigate the value of cystatin C-based estimated glomerular filtration rate （eGFR-CysC） combined with thromboelastogram （TEG） to predict clinical prognosis of patients with acute-on-chronic liver failure （ACLF）.
Ba Zhiwei, Zhao Wen, Liu Chuanmiao
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Application of extracorporeal membrane oxygenation to adults with cardiogenic shock and cardiac arrest in hospital [PDF]
, 2023 Objective·To assess the effect of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) treatment on the mortality rate of patients suffering from cardiogenic shock and cardiac arrest in hospital.Methods·A total of 19 patients with cardiogenic ...
HUANG Chaofa +5 more
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