Results 31 to 40 of about 15,660 (166)
Politics &Policy, Volume 53, Issue 5, October 2025.ABSTRACT In response to calls to extend the theoretical development of the multiple streams framework (MSF), this article proposes the integration of a refined problem framing process model and its key settings into the MSF. Despite its popularity in recent decades, the MSF has not systematically addressed the role of contextual factors in the problem ...
Wenjin Chen, Naubahar Sharif, Xinyi Wang
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2004 【目的】探讨生长激素对原发性肝癌的作用及联合化疗的治疗效果。【方法】建立人原发性肝癌原位移植瘤模型,并将23只荷瘤裸小鼠随机分成对照组(A组),化疗药物治疗组(B组),生长激素组(C组),生长激素联合化疗药物治疗组(D组);治疗2周,观察各组裸小鼠的治疗效果。【结果】与实验前比较,生长激素组裸小鼠体质量增加,差异具统计学意义 ...
赖佳明
doaj
The isolation and identification of anticancer compounds targeting nuclear receptor from leaves of Magnolia biloba and seeds of Camellia oleifera [PDF]
, 2015 靶点药物研究已成为现代新药研究与开发的潮流，而核受体被发现与多种重大疾病特别是癌症的发生发展关系密切，并已被确认是一种理想的药物靶标。孤儿核受体TR3/Bcl-2凋亡途径及tRXRα/p85信号转导通道是本研究团队近年来发现的两条独特的癌细胞凋亡调控通路。寻找靶向并调控这些核受体信号通路的小分子药物将能特异有效的抑制肿瘤细胞的生长，十分具有开发成新型靶向抗癌药物的潜力。我们前期科研成果的基础上，建立生物活性筛选模型 ...
石欣蕾
core
Veterinary Dermatology, Volume 36, Issue 5, Page 630-637, October 2025.Background – Recurrent urticaria is common in horses. The pathophysiology is poorly understood and treatment options are limited. Often only glucocorticoids are effective for controlling clinical signs, albeit with potential adverse effects. Studies investigating new treatments need a validated objective scoring system for the grading of skin lesions ...
Katharina Birkmann +5 more
wiley +1 more source
轻微型和控制型卵巢刺激对卵巢低反应患者卵泡液微环境的不同影响
Zhongshan Daxue xuebao. Yixue kexue ban, 2018 【目的】比较卵巢低反应患者进行卵巢轻微刺激和控制性卵巢刺激体外受精-胚胎移植（IVF-ET）周期中卵泡液内激素水平、细胞因子的差异及其与获卵数、胚胎数等的关系。【方法】本研究为观察性研究。招募符合博洛尼亚标准的卵巢低反应患者，随机分为实验组（组2）和对照组（组1）。实验组采用来曲唑及低剂量外源性促卵泡生成素（Gn）进行卵巢轻微刺激，对照组采用常规控制性卵巢刺激（黄体期GnRH激动剂修饰长方案）进行卵巢刺激。于取卵日收集成熟卵泡（>16 mm）的卵泡液，其中实验组共23例，对照组共28例 ...
李婷婷, 张晓莉, 黄睿
doaj
The use of sex hormones in women with rheumatological diseases [PDF]
, 2011 A number of rheumatological diseases predominantly affect women of reproductive age. There has always been concern that the use of oestrogen-containing agents such as combined hormonal contraception and hormone therapy might aggravate these conditions ...
Gebbie, AE +5 more
core
Is parvovirus B19 infection upsurge in 2023–2024 associated with adverse pregnancy outcome?
Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 3, Page 307-313, September 2025.ABSTRACT Objective A surge in parvovirus B19 infections has been reported in 2023–2024 across Europe and the USA, raising concerns about the associated perinatal risks. The aim of this study was to compare perinatal outcomes following maternal parvovirus B19 infection during the 2023–2024 period with those from a pre‐2023 cohort.
S. Prasad +22 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】探讨褪黑激素对体外培养新生大鼠神经干细胞分化的影响。【方法】从新生SD 大鼠室管膜下区分离依 赖碱性成纤维细胞生长因子(bFGF)和表皮细胞生长因子(EGF)生存的神经干细胞进行培养, 原代及子代细胞鉴定后用于实 验。实验细胞均在无生长因子而含10 mL/ L 胎牛血清条件下培养, 经褪黑激素或Luzindole 作用1 周后做免疫组织化学染色, 比较Map2 阳性细胞出现率。【结果】①依赖bFGF 和EGF 生长的神经干细胞体外呈集落样生长, 表达抗原蛋白巢蛋白 (Nestin ...
胡黎平, 谢富康, 李海标
doaj
Pollution Characteristics and Preliminary Risk Assessment of Organic agrochemicals in Surface Water of Jiulong River Watershed [PDF]
, 2015 农用化学品作为重要的农业生产资料之一，在提高农产品生产率方面发挥着重要作用。农药、兽药等农用有机化学品使用后可能通过干湿沉降、地表径流冲刷等途径进入水环境，威胁水生生态系统健康，导致饮用水源污染、食品安全等问题。 本论文选择常用的40类210种农药（包括氨基甲酸酯类、拟除虫菊酯类、酰胺类、唑类等）和21类100种兽药（包括大环内酯类、四环素类、磺胺类、性激素类等）作目标物，分别建立其在表层水中的分析方法，应用于九龙江流域北溪、西溪、河口农用有机化学品复合污染状况研究 ...
陈茜茜
core
Reactive oxygen species act as signaling molecules to control root hair initiation and tip growth
New Phytologist, Volume 247, Issue 5, Page 2042-2048, September 2025.Summary Root hairs (RHs) increase the surface area of roots, facilitating nutrient and water uptake and plant anchorage. RHs form from root epidermal cells and elongate by polar tip growth. Reactive oxygen species (ROS) have recently been implicated as important signals that drive RH formation and elongation using both genetic and imaging approaches ...
Megan E. Gerber +2 more
wiley +1 more source