Results 11 to 20 of about 535,408 (183)
摘 要: 【目的】 研究盘状结构域受体(DDR1)的抑制剂3-(2-(吡唑并[1,5-a]嘧啶-6-基)乙炔基)苯甲酰胺7RH对鼻咽癌细胞的体外抗肿瘤作用及相关机制,为该药用于鼻咽癌的临床治疗提供实验依据。【方法】 采用MTT法绘制细胞生长曲线,计算7RH对鼻咽癌细胞的半数抑制浓度(IC50值);Western Blot检测7RH引起鼻咽癌细胞中信号通路的改变,并检测SiRNA瞬时转染方法干扰DDR1后phospho-IGF-1R的改变。【结果】 7RH在体外明显抑制鼻咽癌细胞的增殖并且呈浓度依赖性 ...
doaj +1 more source
コミュニケーション回避としての発言抑制発生機序モデルの検討 [PDF]
本研究は、坂本・プリブル・キートン(1998)のコミュニケーション回避に関する理論モデルを基に発言抑制に関する仮説モデルを構築し検証したものである。発言抑制に関する遺伝的素質として行動抑制系(BIS)、早期に作られる認知的機構として不合理な信念を想定し、それらによって生じる状態不安が発言抑制を発生させるという仮説の下、理論上時間的に先行する概念から現在の状態へとパス図の構成要素を配置し、因果関係を想定している。 170名の大学生に対する質問紙調査を実施した。因子分析の結果、大学生の発言抑制は ...
コヤマ, ケンイチロウ +7 more
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ABSTRACT One key strategy that local universities and the government of Hong Kong have adopted in recent years is attracting more students from Chinese Mainland to study at Hong Kong's higher education institutions and contribute to society after graduation.
Lingnan Zhang, Yue Peng
wiley +1 more source
Fighting Corruption Through Accountability? A Survey Experiment 感覺課責能否抑制貪腐?來自調查實驗的證據
ABSTRACT Democratic Weberian bureaucracy is facing great challenges upholding public values as we see turbulent party politics disrupt merit‐based systems, causing bureaucrats' goal displacement and conflicting compliance under multiple accountability mechanisms.
Ming‐feng Kuo, Hsini Huang
wiley +1 more source
ABSTRACT This study developed a metal–modified fluoroethylene vinyl ether (FEVE) organic coating on 6061 aluminum alloy, supported by a micro‐arc oxidation (MAO) pretreatment layer, to enhance corrosion resistance and antifouling performance in marine environments.
Chang Liu +5 more
wiley +1 more source
ABSTRACT Tumor metastasis and recurrence are major reasons for the difficulty in curing cancer. Although some immunotherapy methods have been developed, they are still limited by immunosuppression, resulting in limited therapeutic efficacy against tumors.
Chen Ye +4 more
wiley +1 more source
ABSTRACT Biodegradable zinc (Zn)‐based materials are considered promising candidates for orthopedic applications because of their favorable mechanical properties, controllable biodegradability, and good biosafety profiles. However, their clinical translation is limited by early‐stage corrosion‐induced cytotoxicity and inflammation, as well as ...
Jinlong Mao +9 more
wiley +1 more source
ABSTRACT Bimodal grain structure (BGS) demonstrates significant potential in synergistically optimizing the strength and plasticity of magnesium alloys. Acquiring the desired BGS consequently became a critical challenge. This study took the Mg‐9Gd‐1Zn‐0.5Zr (wt%, VZ91K) alloy as its subject. From the perspective of BGS formation mechanisms, it suggests
Shuai Yuan +5 more
wiley +1 more source
ABSTRACT In conventional photoconductive detectors, the shared collection path for dark current and photocurrent imposes a fundamental compromise between noise suppression and signal responsivity. To break this trade‐off, we introduce a device architecture featuring a strategically integrated third electrode within a MAPbI3/Nb2CTx heterostructure. This
Yan‐Wei Lv +7 more
wiley +1 more source

