Results 21 to 30 of about 648,087 (161)
目的探讨蛋白质磷酸化酶抑制剂对肺癌细胞株的增殖抑制作用。方法用蛋白质磷酸化酶抑制剂对6株小细胞肺癌和7株非小细胞肺癌细胞株的增殖抑制效果进行了检测,并采用免疫法,测定了蛋白质磷酸化酶抑制剂对肺癌细胞内Rb蛋白表达的影响。结果随其浓度的增加,对肺癌细胞株的增殖抑制作用增强,小细胞肺癌的半数抑制量平均值ST为95nM,UCN-01为588nM,非小细胞肺癌则分别为188nM和1029nM,ST和UCN-01可抑制肺癌细胞Rb蛋白的磷酸化。结论蛋白质磷酸化酶抑制剂通过抑制Rb蛋白的磷酸化 ...
赵美蓉, 王杨, 裴瑞莲
doaj
ABSTRACT Carbides strengthen the grain boundaries; nevertheless, excessive carbide precipitates embrittle the grain boundaries of high‐temperature alloys during prolonged service. Here, we provide direct evidence of solute rare‐earth atoms and demonstrate that they can trap vacancies and inhibit interstitial diffusion, restraining carbide precipitation
Jiali Zhang +10 more
wiley +1 more source
Bidirectional Interfacial Chemical Regulation Enables Durable Aqueous Zn‐I2 Batteries
ABSTRACT Aqueous Zn‐I2 batteries hold great promise for large‐scale energy storage, yet their practical deployment is hindered by coupled interfacial instabilities at both electrodes, where Zn‐anode parasitic reactions and cathodic polyiodide shuttle mutually aggravate each other.
Zimian Jia +8 more
wiley +1 more source
Functionalized Silica‐Constructed Self‐Supporting Composite Separator for Lithium Metal Batteries
ABSTRACT Lithium metal batteries (LMBs) are considered highly promising next‐generation energy storage systems owing to their exceptionally high theoretical specific capacity and ultralow electrochemical potential. Nevertheless, the practical deployment of LMBs is still severely restricted by the uncontrollable formation and propagation of lithium ...
Li Chen +6 more
wiley +1 more source
ABSTRACT Gram‐negative (G−) bacterial infections, fueled by intrinsic antibiotic resistance stemming from their unique outer membrane architecture, pose a critical global clinical challenge. This study introduces a pioneering dual‐enzyme‐mimetic nanotherapy based on NaYbF4 nanoparticles (NaYbF4 NPs) that achieves synergistic antibacterial and anti ...
Yuxiang Zhang +6 more
wiley +1 more source
视觉系统会优先选择与当前行为目标相关的刺激,忽略无关刺激。这种视觉优先选择(prioritizing selection)现象及其机制一直是视觉搜索研究所关注的焦点。本研究对预览搜索(preview search)中优先选择的解释机制进行了详尽的探讨,从基于旧干扰物位置的抑制和基于旧干扰物属性特征的抑制两方面系统检验了基于抑制的视觉标记的解释,并基于实验结果提出了预览搜索中优先选择的非抑制加工机制。 本研究分为三个部分,共9个实验:研究一考察预览搜索的优先选择是否是基于旧干扰物位置的抑制 ...
郝芳
core +1 more source
从玉米种子纯化出两种巯基蛋白酶抑制剂(CPI Ⅰ和CPI Ⅱ),分子量分别为9500和13000,它们都只抑制巯基蛋白酶的水解活性,而对丝氨酸蛋白酶则无抑制作用,属于巯基蛋白酶水解抑制剂,它们在pH3.0~11.0或100℃温度范围内保有100%的抑制木瓜蛋白酶的抑制活性,表明在这些外界条件下其分子非常稳定.
邓俊林, 曾仲奎
doaj
ABSTRACT A synergistic strategy combining a Ti interlayer and circular beam oscillation was proposed to improve the laser weldability of 6082‐T6 aluminum alloy. The Ti interlayer suppressed porosity, eliminated columnar grains, and significantly reduced grain size by 67.7% at the weld center. Mechanistically, fine L12‐Al3Ti precipitates clearly showing
Zhongping Hou +8 more
wiley +1 more source
ABSTRACT Non‐noble metal oxygen electrocatalysts are essential for low‐cost rechargeable metal‐air batteries and fuel cells, determining their energy conversion efficiency. However, such electrocatalysts are limited by inadequate bifunctional activity and stability toward the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER).
Lixin Sun +14 more
wiley +1 more source
ABSTRACT Regulating oxygen vacancies (Ov) in SnO2 to facilitate high‐efficiency carbon dioxide electroreduction reduction reaction (CO2RR) is still a significant challenge. Therefore, a strategy based on Ag‐induced interfacial electron transfer was proposed to modulate Ov in SnO2 for CO2 electroreduction. The prepared Ag/SnO2 with an optimal Ov content
Haoyu Qi +7 more
wiley +1 more source

