双链ＲＮＡ依赖的蛋白激酶在非小细胞肺癌预后预测及靶向治疗中的作用
Zhongshan Daxue xuebao. Yixue kexue ban, 2012 【目的】 探索双链ＲＮＡ依赖的蛋白激酶（ＰＫＲ）联合其他肿瘤代谢相关蛋白能否作为非小细胞肺癌（ＮＳＣＬＣ）的更有效的预测因子；同时拟研究部分肿瘤代谢相关化合物，如胰岛素样生长因子１受体（ＩＧＦ-１Ｒ）抑制剂、哺乳动物雷帕霉素靶蛋白（ｍＴＯＲ）抑制剂等与ＰＫＲ表达的关系，拟求达到更好的靶向治疗及个体化治疗的目的。【方法】 免疫组化检测２１２例ＮＳＣＬＣ中ＰＫＲ、ＩＧＦ-１Ｒ表达情况，并用于Ｋａｐｌａｎ-Ｍｅｉｅｒ生存分析。Ｗｅｓｔｅｒｎ Ｂｌｏｔｔｉｎｇ检测１３种肺癌细胞株ＰＫＲ、ｐ-ＰＫＲ表达 ...
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[Curcumin improves osteoporosis in type 2 diabetic mice by inhibiting RANBP3L expression]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZou X, Zhang X, Li P, Tian R, Lu X.
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[Cannabinoid receptor 2 inhibition on acantholysis in oral mucosal pemphigus]. [PDF]
Hua Xi Kou Qiang Yi Xue Za ZhiLiu H +5 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2010 【目的】 观察一氧化氮(NO)信号途径在膜雌激素受体介导的内皮祖细胞(EPCs)增殖和凋亡中的作用65377; 【方法】 在培养的EPCs上,分别使用E2-BSA65380;或加雌激素受体阻断剂ICI 182,78065380;PI3K抑制剂LY294002和NOS抑制剂l-NAME,利用噻唑蓝(MTT)法检测细胞增殖活性(10组,n = 9),利用化学比色法测定NO的含量(6组,n = 6),Hoechst 33258染色观察EPCs凋亡(8组,n = 5 ...
doaj
[GSK484, a PAD4 inhibitor, improves endothelial dysfunction in mice with sepsis-induced lung injury by inhibiting H3Cit expression]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoSu X, Li L, Dai J, Xiao B, Jin Z, Liu B.
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[Therapeutic mechanism of hederagenin, an active component in <i>Guizhi Fuling</i> Pellets, against cervical cancer in nude mice]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhu Y +6 more
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[Inhibition of BRD4 promotes migration of esophageal squamous cell carcinoma cells with low ACC1 expression]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoJia W, Huo S, Tang J, Liu Y, Zhao B.
europepmc +1 more source
[Fufang Changtai Decoction Inhibites Colorectal Cancer Through Ferroptosis: Investigation of the Underlying Mechanism]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanGu J +6 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2013 【目的】 了解药物成瘾者的认知功能状况以及工作记忆在情绪对抑制性影响中的调节作用?【方法】 采用医院焦虑抑郁量表,连续工作任务(CPT),2-back任务对150名药物成瘾者和100名在年龄?性别?教育年限以及智商相匹配的非药物成瘾者实施情绪状态,抑制性和工作记忆的测试,然后采用独立样本t检验了解成瘾组和对照组在情绪?工作记忆和抑制性上的差异,相关?回归分析以及中介效应检验探讨工作记忆在焦虑和抑制性间的中介效应?【结果】 成瘾组在工作记忆(2-back正确率)?焦虑?抑郁和抑制性(CPT虚报率 ...
doaj
[<i>Yiqi Jiedu</i> Formula inhibits proliferation, invasion and migration of nasopharyngeal carcinoma cells by inhibiting the AKT1/GLUT1 signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoXu H +8 more
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