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随着全球人口老龄化进程的加快,肌少症作为一种以骨骼肌质量、力量与躯体功能持续性下降为特征的老年综合征,已成为严重威胁老年人健康和生活质量的重要公共卫生问题。其发生发展过程涉及多层次、跨系统的细胞与分子机制。近年来研究发现,程序性细胞死亡(PCD)在骨骼肌稳态维持、代谢调节与组织修复中发挥核心作用。凋亡、自噬、焦亡与铁死亡等典型PCD形式通过活性氧(ROS)积聚、线粒体功能障碍与铁稳态破坏等关键节点相互串扰,驱动肌纤维丢失、肌肉功能减退及慢性炎症反应,是肌少症发生发展的重要病理基础 ...
史雪珂, 冯晓东
doaj
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[Research progress in liver cancer in 2025]. [PDF]
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[Research Progress of Peripheral Immune Tolerance in Oral Diseases]. [PDF]
Wen K, Zhang P, Peng X.
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