Results 31 to 40 of about 695,843 (110)
当研究室では、貧血の病態の1つとして知られているエリスロポエチン(erythropoietin ; EPO)低反応性に関与する可能性のある新規因子として、貧血患者の血清中に内因性の抗EPO受容体抗体を同定した。また、前年度までの臨床的検討から、ELISA法による抗EPO受容体抗体の吸光度の大きさと患者骨髄中の赤芽球や網赤血球数と相関を認めたことより、同抗体が貧血の病態形成に関与することが示唆された。そこで今年度は、抗EPO受容体抗体の生物学的特性を明らかにする目的で、さらなる生化学的検討に取り組んだ ...
原, 章規, 70507045, 461
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Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Surface‐enhanced Raman scattering (SERS) has emerged as a highly sensitive and specific technique for tumor imaging, owing to its narrow spectral features, resistance to photobleaching, and capability for multiplexed detection. However, its clinical translation remains limited by poor tissue penetration and the absence of intrinsic anatomical ...
Xinyu Miao +7 more
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全身性強皮症における抗MMP-1抗体、抗MMP-3抗体について [PDF]
Human recombinant MMP-1,MMP-3を用いたELISA法により、全身性強皮症(以下SSc)血清中の抗MMP-1抗体価および抗MMP-3抗体価の経時的変化を評価した。抗MMP-1抗体価は、全経過を通じて変化することはなかった。抗MMP-3抗体価は、病初期高値を示し、経時的に低下する傾向が認められた。しかし、経過中肺線維症の増悪など病勢の増悪を認めた例においても病勢増悪を反映するような抗体価の再上昇は認められなかった。また、間質性肺炎のマーカーとして知られているKL-6,SP ...
西島, 千博, 70324118, 96152
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Engineering Photothermal Nanoplatforms for Multimodal Theranostics and Biosensing
Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Photothermal platforms bridge materials science and biomedicine, emerging as a transformative frontier in biomedical applications. They offer spatiotemporally precise, noninvasive modalities with cell‐type‐independent efficacy for treating a range of diseases.
Xiao Han +3 more
wiley +1 more source
Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Wearable sweat sensors face persistent trade‐offs between multiplexed detection, signal stability, and wearing comfort. Here, we present a Janus electronic skin (e‐skin) with dual‐mode functionality, offering both thermal and moisture comfort.
Zhi‐Mei Mu +12 more
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Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Lithium‐rich manganese‐based cathodes (LRM) deliver high discharge capacities beyond 250 mAh g−1, but their practical deployment is restricted by irreversible oxygen redox, structural reconstruction, sluggish kinetics and unstable cathode‐electrolyte interfaces (CEI). Here, we develop a colloid‐assisted anchoring‐diffusion engineering strategy
Jia‐Nan Hao +13 more
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Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Developing rapid, precise gas sensors for Listeria monocytogenes (LM) biomarker detection faces challenges due to suboptimal gas‐solid interactions. Herein, we report the rational synthesis of amino‐functionalized mesoporous SiO2 hollow nano‐doughnuts (MS‐2‐NH2‐2) via modification with (3‐aminopropyl) trimethoxysilane (AAPTMS), which enables ...
Xingyu Wang +7 more
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Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Spent automotive exhaust catalysts represent the largest secondary resource of palladium (Pd), and their efficient recovery is essential to support the sustainability of Pd‐related industries. Inspired by supramolecular chemistry, a novel calixarene derivative, 5,11,17,23‐tetra‐tert‐butyl‐25,27‐bis[(N′‐hydroxyacetimidamide)ethoxy]‐26,28 ...
Tao Ge +8 more
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, 2011 本发明公开了一种抗鳜鱼弹状病毒糖蛋白的单克隆抗体及其制备方法和应用,以及产生 该单克隆抗体的杂交瘤细胞株SCRV-G-1B2,CCTCC No：C200918。其制备步骤是：以纯化的 鳜鱼弹状病毒为抗原,免疫BALB/c小鼠,经细胞融合,产生融合的杂交瘤细胞,再经间接 ELISA筛选和有限稀释法单克隆化,获得稳定分泌抗鳜鱼弹状病毒糖蛋白单克隆抗体的杂交 瘤细胞株。本发明能获得活性更高、特异性更强、数量更多的鼠脾脏淋巴细胞,以保证所 获得的融合杂交瘤细胞效果更好 ...
张奇亚, 陈中元
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, 2011 抗体是高等动物特异性免疫应答反应所产生的免疫球蛋白,负责特异抗原的识别和清除。抗体不仅是机体抵抗病原体入侵的强大武器,也是基础科学研究中用于特异性分子识别的专用工具。抗体分子的多样性导致了抗体库概念的产生,让我们认识到每个高等生物个体都是一个天然的抗体库。在后基因组时代,为了适应各种"组学"研究,特别是为了蛋白质组学研究的高通量技术需求,在噬菌体展示技术平台的基础上,构建了各种基因工程抗体库和抗体替代物库。但现在越来越多的其他展示技术如核糖体展示、mRNA展示等体外展示技术也被用于抗体库的研究 ...
戴和平
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