慢性乙肝患者拉米夫定耐药后出现肝功能衰竭的危险因素 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2007 【目的】探讨慢性乙型肝炎患者拉米夫定耐药后出现肝功能衰竭的危险因素。【方法】拉米夫定耐药后导致病情加重的慢性乙型肝炎患者56例纳入研究．记录拉米夫定治疗前病程、诊断、拉米夫定疗程，检测并记录临床耐药时的肝功能、乙肝两对半、HBVDNA定量、YMDD变异及前C区变异。按病情加重后的诊断分为肝功能衰竭组和慢性乙型肝炎组进行比较。【结果】肝功能衰竭组患者年龄（45±13）岁，大于慢性乙型肝炎组（37±131岁（P〈0．05）；肝功能衰竭组临床耐药时HBV DNA载量高于慢性乙型肝炎组[（2．8×10^8＋4 ...
邓洪 +5 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】研究拉米夫定对HBsAg 阳性孕妇的乙肝病毒(HBV)宫内阻断作用。【方法】拉米夫定组43 例, 孕28 周 起口服拉米夫定, 每天100 mg 至产后30 d 。对照组52 例, 未予用药。两组孕妇均于孕28 周、分娩前, 其新生儿于生后24 h 内免疫接种前抽静脉血检测HBsAg 、HBeAg 及HBV 的定量。【结果】拉米夫定组孕妇HBV 的DNA 水平显著下降(P < 0.05), 其新生儿宫内感染率(16.3 %)明显低于对照组(32.7 %), P
杨越波 +5 more
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Chinese expert consensus on clinical application of recombinant oncolytic adenovirus in the treatment of malignant tumors [PDF]
, 2023 Treatment using oncolytic virus as a new tumor immunologic agent has made continuous breakthroughs in basic and clinical research of tumor in recent years, and it is expected to play an important role in cancer immunotherapy in the future.
Expert Committee on Immunotherapy of Chinese Society of Clinical Oncology , Professional Committee on Cancer Biotherapy of Shanghai Anticancer Association
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A case of Brucella Cases Analysis and Discussion [PDF]
, 2017 临床药师参与1例布鲁氏菌病感染常规方案治疗无效患者的临床诊断与治疗全过程,通过参与医生查房、病例讨论等提出自己意见,对提高诊治水平、优化治疗方案、合理使用抗菌药物起到了推动作用,最终患者好转并出院.为明确布鲁氏菌病诊断,促进临床合理用药累积了宝贵的经验.Clinical pharmacists participated in treatment of 1 cases of brucellosis infection which conventional treatment was invalid ...
林清江, 魏吟秋, 黄阅欣
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Primary biliary cholangitis complicated with eosinophilic granulomatous with polyangiitis: a case report [PDF]
, 2023 The etiology of primary biliary cholangitis （PBC） is unclear， which may be associated with genetic， hereditary and environmental factors， etc. Ursodeoxycholic acid （UDCA） is the first-line drug for the treatment of PBC.
Xiao Qiao, Xiao Hua, Wang Rong, Zhao Chuan
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Meta-analysis of Curative Effects and Safeties of Baraclude Versus Other Nucleoside Drugs for Treatment of HBeAg-positive Chronic Hepatitis B [PDF]
, 2017 目的：评价博路定和其他抗乙肝病毒核苷酸类药物对核苷初治的乙型肝炎 e 抗原（HBeAg）阳性慢性乙型肝炎（CHB）患者的疗效和安全性。方法：计算机检索 PubMed、Mestre、中国期刊全文数据库（CNKI）、中文科技期刊数据库（VIP）、万方数据库（建库至2015年10月）公开发表的有关博路定和其他抗乙肝病毒核苷酸类药物对核苷初治的 HBeAg 阳性 CHB 患者疗效的随机对照试验（RCTs），并追查已获文献的参考文献。由两名研究者独立筛选文献，提取数据，按照改良后 Jadad 评分标准进行质量评价。
严国鸿 +5 more
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Efficacy and safety of raltegravir-based therapy in antiretroviral-naive patients with HIV-1 infection: A Meta-analysis [PDF]
, 2017 目的评价联合雷特格韦治疗方案用于人类免疫缺陷病毒-1 human immunodeficiency virus; 1,HIV-1)初次抗病毒治疗的安全性和有效性。方法检索联合雷特格韦用于HIV-1感染者初次抗病毒治疗的临床随机对照试验(randomized; controlled trial,RCT),采用Rev Man 5.2软件和Stata; 12.0进行Meta分析。结果纳入17个RCT,Meta分析结果:以血浆病毒载量0.05);治疗240周,试验组有效率高于对照组(70.2%和61.5 ...
张峰 +6 more
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响应面优化浊点萃取联会 HILIC 测定大鼠血清中四种抗艾滋病药 [PDF]
, 2020 【目的】基于浊点萃取技术（CPE）联合亲水作用色谱法（HILIC）同时测定大鼠血清中四种抗艾滋病药。【方法】以TritonX-114作为萃取介质，用响应面法进一步优化CPE相关参数，对萃取的样品，用HILIC法分别测定其含量。【结果】四种抗艾滋病药在5%（w/v）TritonX-114，0.3mol/L NaCl，pH为5.0，40℃水浴平衡20 min时，萃取率均达85.0%以上，与模型预测值接近；对于富集的样品，以Ze month-CN（250mm×4.6mm，5μm）为固定相，流动相为（甲醇∶乙腈∶
安琼, 杨建霞, 王贞香, 赵秀丽
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The study on GCOE modified AZTS-loaded liposomes [PDF]
, 2012 艾滋病(AcquiredImmuneDeficiencySyndrome，AIDS)是由人类免疫缺陷病毒(HumanImmunodeficiencyVirus，HIV)感染导致人体免疫机能缺陷而易于发生机会性感染和肿瘤的临床综合征。高效抗逆转录病毒疗法(HighlyActiveAntiretroviralTherapy，HAART)能抑制HIV复制，降低AIDS的发病率和死亡率，但仍存在药物无法彻底清除HIV、难以在HIV病毒贮库中达到有效浓度、长期用药易产生多药耐药等问题。因此 ...
王凌嵩
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Drug-herb interactions between Scutellaria baicalensis and pharmaceutical drugs : insights from experimental studies, mechanistic actions to clinical applications [PDF]
, 2021 Whilst the popular use of herbal medicine globally, it poses challenges in managing potential drug-herb interaction. There are two folds of the drug-herb interaction, a beneficial interaction that may improve therapeutic outcome and minimise the toxicity
Fu, Ling +5 more
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