随着全球人口老龄化进程的加快,肌少症作为一种以骨骼肌质量、力量与躯体功能持续性下降为特征的老年综合征,已成为严重威胁老年人健康和生活质量的重要公共卫生问题。其发生发展过程涉及多层次、跨系统的细胞与分子机制。近年来研究发现,程序性细胞死亡(PCD)在骨骼肌稳态维持、代谢调节与组织修复中发挥核心作用。凋亡、自噬、焦亡与铁死亡等典型PCD形式通过活性氧(ROS)积聚、线粒体功能障碍与铁稳态破坏等关键节点相互串扰,驱动肌纤维丢失、肌肉功能减退及慢性炎症反应,是肌少症发生发展的重要病理基础 ...
史雪珂, 冯晓东
doaj
[Microbial communities in extraradicular infections of post-treatment apical periodontitis without or with sinus tracts]. [PDF]
Tang R, Yang L, Nie J, Wang X.
europepmc +1 more source
[Research on tissue regeneration and engineered scaffold materials in prevention and treatment of lymphedema]. [PDF]
Yuan S, Deng C.
europepmc +1 more source
[Advances on efficacy and mechanisms of acid fibroblast growth factor for promoting injured tissue repair]. [PDF]
Zhu F +5 more
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目的综合评估西柳沟流域长时间序列下景观格局指数及生境质量现状变化,为合理制定生态修复方案,促进流域生态经济的可持续发展提供理论依据。方法选取2000年、2005年、2010年、2015年、2020年5个时段,基于Fragstats、InVEST模型和地理探测器对西柳沟流域景观格局指数、生境质量现状及其驱动力因素进行分析。结果1)2000—2020年研究区景观呈明显的聚集化与同质化的变化趋势,主要表现为草地扩张、景观破碎度降低、边缘复杂度下降和多样性减少 ...
张锦鑫 +7 more
doaj
[Clinical characteristics, treatment, and prognosis of double-hit multiple myeloma with concurrent 1q21+ and t (4;14)]. [PDF]
Guo Y +8 more
europepmc +1 more source
[Efficacy and safety of super electroconvulsive therapy for treatment-resistant depression: a retrospective analysis of 292 cases]. [PDF]
An J, Chi Z, Zhao C, Li Y, Wang R, Hu Y.
europepmc +1 more source
[Trends in burden of osteoporosis in China from 1990 to 2023 and analysis of epidemiological factors]. [PDF]
Wu Y +5 more
europepmc +1 more source
[Trends of disease burden on spinal cord injury in China from 1990 to 2023]. [PDF]
Yang F, Han Y, Pan W, Luo X.
europepmc +1 more source
[Temporal changes of chronic postsurgical pain in mice: the regulatory role of CX3CL1 in the dorsal root ganglion]. [PDF]
Zhao B +8 more
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