Results 41 to 50 of about 25,148 (152)

miRNA-210、乳酸差值、乳酸脱氢酶在颅脑损伤合并脑梗死中的表达及临床意义

open access: yesZhongguo shiyan zhenduanxue, 2021
目的研究miRNA-210、乳酸差值、乳酸脱氢酶在颅脑损伤合并脑梗死中的表达及临床意义。方法选取2017年7月-2018年7月在秦皇岛市第一医院治疗的颅脑损伤合并脑梗死患者79例作为损伤合并组,另选取颅脑损伤患者79例作为颅脑损伤组,健康体检的79例作为正常组,采用酶联免疫吸附试验(ELISA)检测miRNA-210、乳酸脱氢酶;分析miRNA-210、乳酸差值、乳酸脱氢酶在颅脑损伤合并脑梗死中的表达及临床意义。结果与正常组相比,颅脑损伤组、损伤合并组miRNA-210、乳酸脱氢酶水平均显著升高 ...
孙惠芳, 杨文宏, 邱方
doaj  

The study of brain function changes and related molecular mechanism of rat with chronic obstructive pulmonary disease [PDF]

open access: yes, 2015
目的 慢性阻塞性肺病(chronicobstructivepulmonarydisease,COPD)以不完全可逆的气流受限和全身系统炎症为特征,可造成脑部供氧不足和神经炎症,导致脑细胞损伤。本研究利用分子生物学等方法探究COPD大鼠脑损伤的分子机制,并为快速诊断出COPD和临床治疗提供依据。 材料和方法 材料:雄性SD大鼠由厦门大学实验动物中心提供,体重230-280g,随机分成4组,健康对照组,吸烟组,脂多糖组,吸烟+脂多糖组,饲养在相同环境下,给予充足的水和食物。 研究方法 ...
严亚
core  

Structure and satisfaction: Social support networks among older grandparents raising adolescent grandchildren

open access: yesJournal of Elder Policy, Volume 4, Issue 1, Page 33-46, April 2025.
Abstract Older custodial grandparents raising adolescent grandchildren are often underprepared to parent adolescent grandchildren with complex biological, psychological, and social needs. Greater understanding of social support networks may contribute to enhancing the well‐being and longevity of these caregivers.
Tina Peterson
wiley   +1 more source

European Biometric Borders and (Im)Mobilities in West Africa: Reflections on Migrant Strategies for Border Circumvention and Subversion

open access: yesPolitics &Policy, Volume 53, Issue 1, February 2025.
ABSTRACT This article argues that the European biometric ID installations and securitization practices at West African borders harm African migrants and compromise the security goals of Europe and Africa. Using Niger's experience, I contend that migrants' poor adaption to the biometric border processes is closely connected to their identity conflicts ...
Victor Chidubem Iwuoha
wiley   +1 more source

大鼠颅脑外伤后突触素P38在中枢神经系统的表达变化

open access: yesZhongguo shiyan zhenduanxue, 2009
目的观察大鼠颅脑外伤后突触素p38在中枢神经系统表达的变化。方法将SD大鼠分为正常对照组、假手术对照组和损伤组,损伤组用侧位液压冲击法应用不同压力制成颅脑损伤动物模型,于损伤后不同时间点采集标本,采用免疫组织化学技术,检测大鼠损伤灶周边皮层及海马CA1区p38的表达变化,结果采用方差分析和q检验进行统计学分析。结果创伤性颅脑外伤后,损伤灶周边皮层及海马CA1区p38免疫阳性表达增强。结论中枢神经系统损伤后,突触素p38表达增强,且损伤越重,表达增强越明显。
栾永昕, 左玲, 张剑涛, 罗毅男
doaj  

The association between the antioxidant property and ROS system in murine corneal epithelial progenitor cells [PDF]

open access: yes, 2016
目的:活性氧(ROS)是体内产生的一种高活性分子,低浓度可以调节细胞代谢,基因转录和磷酸酶的活性,高浓度则会导致氧化损伤。目前,有关干细胞自身特性的研究越来越受到学者们的重视,但既往文献中关于干细胞对氧化应激反应以及应激条件下细胞内相关酶活性的变化规律却很少报道。本课题聚焦于,在过氧化氢(H2O2)诱导的氧化应激条件下,活性氧生成关键因子NOX4和抗氧化酶核转录因子NRF2在小鼠角膜上皮祖细胞(TKE2)和成熟的小鼠角膜上皮细胞(MCE)中的不同作用及相关机制。 方法:利用小鼠角膜上皮祖细胞(TKE2 ...
周晶
core  

A Meta‐Analysis of Randomized Controlled Trials (RCTs) Investigating the Efficacy and Safety of Acupuncture in Treating Myocardial Ischemia/Reperfusion (I/R) Injury

open access: yesCardiology Research and Practice, Volume 2025, Issue 1, 2025.
Objectives: This study systematically reviewed and meta‐analyzed randomized controlled trials (RCTs) evaluating the efficacy and safety of acupuncture in myocardial ischemia/reperfusion (I/R) injury. Methods: A comprehensive literature search was conducted in PubMed, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, China ...
Jian Xiong   +10 more
wiley   +1 more source

The effect and mechanism of IL-1 R II / IL-1 RAcp in Autoimmune Myocarditis [PDF]

open access: yes, 2016
【目的】白介素-1(IL-1)是一种T淋巴细胞激活因子,大量研究报道,在心肌炎急性期表达量明显升高。白介素1受体II型(IL-1RII)可以招募白介素1受体辅助蛋白(IL-1RAcp),从而拮抗IL-1β的作用。本课题目的为评估IL-1RII和IL-1RAcp的重组质粒对大鼠自身免疫性心肌炎(EAM)的作用,并进一步探讨其机制,为心肌炎的临床治疗提供理论基础。 【方法】首先在临床实验中,我们选取厦门市心血管病医院诊断明确的心肌炎住院患者28例,应用bio ...
宋颖
core  

The HEADS‐ED under 6: Piloting a new communimetric mental health and developmental screening and triage tool for young children

open access: yesInfant Mental Health Journal: Infancy and Early Childhood, Volume 45, Issue 5, Page 557-568, September 2024.
Abstract Communimetric screening tools help clinicians identify and communicate their patient's areas of need and the corresponding level of action. However, few tools exist to identify mental health (MH) and developmental needs in young children. We aimed to implement and evaluate a new communimetric MH and developmental screening tool for children ...
Christine Polihronis   +4 more
wiley   +1 more source

The establishment and mechanism research in the mice model of actue liver failure [PDF]

open access: yes, 2016
背景和目的:急性肝衰竭(acuteliverfailure,ALF)是一个危及生命的严重病理生理状态。它可导致肝脏合成、排泄、解毒、生物转化等功能发生严重障碍或失代偿,出现凝血功能障碍、黄疸以及肝性脑病等主要表现的临床综合征。因其死亡率极高,严重ALF的治疗是当今临床医学中最具有挑战的课题之一。为了有效地治疗ALF,制备与ALF发病经过相同、临床表现类似并可复制的物模型是解决此难题的第一步,而了解各种ALF动物模型的构建机制就显得尤为重要。本课题以氧化偶氮甲烷(azoxymethane,AOM ...
金丽鑫
core  

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